{"created":"2024-02-22T04:49:24.235347+00:00","id":2000509,"links":{},"metadata":{"_buckets":{"deposit":"d77f123c-8c48-436a-9a2f-d27eb738cf58"},"_deposit":{"created_by":9,"id":"2000509","owner":"9","owners":[9],"pid":{"revision_id":0,"type":"depid","value":"2000509"},"status":"published"},"_oai":{"id":"oai:miyazaki-u.repo.nii.ac.jp:02000509","sets":["79","79:42"]},"author_link":["1998","7929","24897","34897","33985"],"item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2024-02-09","bibliographicIssueDateType":"Issued"},"bibliographic_titles":[{"bibliographic_title":"Hypertension Research","bibliographic_titleLang":"en"}]}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Increased blood pressure variability (BPV) was shown to be associated with cardiovascular morbidities and/or mortalities. There are various types of BPV depending on time intervals of BP measurements, ranging from beat-to-beat to visit-to-visit or year-to-year. We previously found that continuous infusion of noradrenaline (NA) for 14 days increased short-term BPV every 15 min in rats. The aims of this study were to examine (1) whether NA infusion increases very short-term beat-to-beat BPV, (2) the effects of azelnidipine and hydralazine on NA-induced BPV, and (3) whether baroreceptor reflex sensitivity (BRS) is affected by NA or NA plus those vasodilators. Nine-week-old Wistar rats infused subcutaneously with 30 μg/h NA were orally treated with or without 9.7 mg/day azelnidipine or 5.9 mg/day hydralazine over 14 days. BP levels were continuously monitored via abdominal aortic catheter with a telemetry system in an unrestrained condition. Standard deviations (SDs) were used to evaluate beat-to-beat BPV and BPV every 15 min which was obtained by averaging BP levels for 10-s segment at each time point. BRS was determined by a sequence analysis. Continuous NA infusion over 14 days increased average BP, beat-to-beat BPV, and BPV every 15 min, lowering BRS. Comparing the two vasodilators, hydralazine reduced BP elevation by NA; meanwhile, azelnidipine alleviated BPV augmentation, preserving BRS, despite a smaller BP reduction. Thus, NA infusion increased both very short- and short-term BPV concomitantly with impaired BRS, while azelnidipine had an inhibitory effect, possibly independent of BP-lowering, on those types of BPV and impairment of BRS.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10001_description_6":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"Citation:\nJiang, D., Matsuzaki, M., Ida, T. et al. Effects of vasodilators on beat-to-beat and every fifteen minutes blood pressure variability induced by noradrenaline infusion in rats. Hypertens Res (2024). https://doi.org/10.1038/s41440-024-01595-w","subitem_description_language":"en","subitem_description_type":"Other"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Springer Nature","subitem_publisher_language":"en"}]},"item_10001_relation_14":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.1038/s41440-024-01595-w","subitem_relation_type_select":"DOI"}}]},"item_10001_rights_15":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"© The Author(s) 2024.","subitem_rights_language":"en"}]},"item_10001_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0916-9636","subitem_source_identifier_type":"ISSN"}]},"item_10001_version_type_20":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Jiang, Danfeng","creatorNameLang":"en"},{"creatorName":"姜, 丹鳳","creatorNameLang":"ja"},{"creatorName":"ジャン, ダンフェン","creatorNameLang":"ja-Kana"}],"familyNames":[{"familyName":"Jiang","familyNameLang":"en"},{"familyName":"姜","familyNameLang":"ja"},{"familyName":"ジャン","familyNameLang":"ja-Kana"}],"givenNames":[{"givenName":"Danfeng","givenNameLang":"en"},{"givenName":"丹鳳","givenNameLang":"ja"},{"givenName":"ダンフェン","givenNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"33985","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Matsuzaki, Minami","creatorNameLang":"en"}],"familyNames":[{"familyName":"Matsuzaki","familyNameLang":"en"}],"givenNames":[{"givenName":"Minami","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"34897","nameIdentifierScheme":"WEKO"}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"0000000106573887","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/0000000106573887"}],"affiliationNames":[{"affiliationName":"宮崎大学","affiliationNameLang":"ja"},{"affiliationName":"University of Miyazaki","affiliationNameLang":"en"}]}],"creatorNames":[{"creatorName":"Ida, Takanori","creatorNameLang":"en"},{"creatorName":"井田, 隆徳","creatorNameLang":"ja"},{"creatorName":"イダ, タカノリ","creatorNameLang":"ja-Kana"}],"familyNames":[{"familyName":"Ida","familyNameLang":"en"},{"familyName":"井田","familyNameLang":"ja"},{"familyName":"イダ","familyNameLang":"ja-Kana"}],"givenNames":[{"givenName":"Takanori","givenNameLang":"en"},{"givenName":"隆徳","givenNameLang":"ja"},{"givenName":"タカノリ","givenNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"1998","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"00381088","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=00381088"}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"0000000106573887","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/0000000106573887"}],"affiliationNames":[{"affiliationName":"宮崎大学","affiliationNameLang":"ja"},{"affiliationName":"University of Miyazaki","affiliationNameLang":"en"}]}],"creatorNames":[{"creatorName":"Kitamura, Kazuo","creatorNameLang":"en"},{"creatorName":"北村, 和雄","creatorNameLang":"ja"},{"creatorName":"キタムラ, カズオ","creatorNameLang":"ja-Kana"}],"familyNames":[{"familyName":"Kitamura","familyNameLang":"en"},{"familyName":"北村","familyNameLang":"ja"},{"familyName":"キタムラ","familyNameLang":"ja-Kana"}],"givenNames":[{"givenName":"Kazuo","givenNameLang":"en"},{"givenName":"和雄","givenNameLang":"ja"},{"givenName":"カズオ","givenNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"7929","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"50204912","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=50204912"}]},{"creatorNames":[{"creatorName":"Kato, Johji","creatorNameLang":"en"},{"creatorName":"加藤, 丈司","creatorNameLang":"ja"},{"creatorName":"カトウ, ジヨウジ","creatorNameLang":"ja-Kana"}],"familyNames":[{"familyName":"Kato","familyNameLang":"en"},{"familyName":"加藤","familyNameLang":"ja"},{"familyName":"カトウ","familyNameLang":"ja-Kana"}],"givenNames":[{"givenName":"Johji","givenNameLang":"en"},{"givenName":"丈司","givenNameLang":"ja"},{"givenName":"ジヨウジ","givenNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"24897","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"20274780","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=20274780"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2024-02-22"}],"filename":"s41440-024-01595-w.pdf","filesize":[{"value":"665 KB"}],"format":"application/pdf","licensetype":"license_0","url":{"label":"article","objectType":"fulltext","url":"https://miyazaki-u.repo.nii.ac.jp/record/2000509/files/s41440-024-01595-w.pdf"},"version_id":"02b87be1-66b1-4281-950b-3f9982aaa2f2"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Blood pressure variability","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Noradrenaline","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Azelnidipine","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Hydralazine","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Baroreceptor reflex sensitivity","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Effects of vasodilators on beat-to-beat and every fifteen minutes blood pressure variability induced by noradrenaline infusion in rats","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Effects of vasodilators on beat-to-beat and every fifteen minutes blood pressure variability induced by noradrenaline infusion in rats","subitem_title_language":"en"}]},"item_type_id":"10001","owner":"9","path":["79","42"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2024-02-22"},"publish_date":"2024-02-22","publish_status":"0","recid":"2000509","relation_version_is_last":true,"title":["Effects of vasodilators on beat-to-beat and every fifteen minutes blood pressure variability induced by noradrenaline infusion in rats"],"weko_creator_id":"9","weko_shared_id":-1},"updated":"2024-07-04T07:21:45.487928+00:00"}