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XPC intron11 C/A polymorphism as a risk factor for prostate cancer
http://hdl.handle.net/10458/0002000473
http://hdl.handle.net/10458/000200047344dcd7af-5ffd-4973-9419-c6b3b71f2eca
| アイテムタイプ | 学術雑誌論文 / Journal Article(1) | |||||
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| 公開日 | 2024-01-31 | |||||
| タイトル | ||||||
| タイトル | XPC intron11 C/A polymorphism as a risk factor for prostate cancer | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 言語 | en | |||||
| キーワード | Cancer risk | |||||
| キーワード | ||||||
| 言語 | en | |||||
| キーワード | DNA repair gene | |||||
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| 言語 | en | |||||
| キーワード | Prostate cancer | |||||
| キーワード | ||||||
| 言語 | en | |||||
| キーワード | XPC-PAT | |||||
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| 言語 | en | |||||
| キーワード | Xeroderma pigmentosum | |||||
| 資源タイプ | ||||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| 著者 |
吉野, 喜裕
× 吉野, 喜裕× 竹内, 昌平× Katoh, Takahiko× 黒田, 嘉紀 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Objectives: DNA repair genes play an important role in protection against environmental and endogenous DNA damage, and constitute the first line of defense against cancer. Xeroderma pigmentosum complementation group C (XPC) is involved in the damage recognition step during nucleotide excision repair. The relationship between XPC intron11 C/A polymorphism and cancer risk has not been widely studied. Hence, this study evaluated the relationship between the XPC intron11 C/A polymorphism and prostate cancer risk. Materials and methods: This hospital-based cohort consisted of 152 patients with prostate cancer and 142 male controls. The XPC intron11 C/A genotype was determined using the PCR-RFLP method. Medical, occupational, and cigarette-smoking history was obtained from each participant using questionnaires. Results: Logistic regression analysis revealed that compared to controls, the frequencies of the A/A and C/A genotypes were significantly higher than those of the C/C genotype in cancer patients (OR = 2.03, 95% confidence interval (CI) 1.03-3.98 and OR = 1.91, 95% CI 1.13-3.24, respectively). We also found that the frequency of the A/A genotype was significantly higher in cancer cases than in controls among non-smokers (OR = 7.7, 95% CI 1.38-42.88, compared to the C/C genotype). Conclusion: We found that the XPC intron11 C/A polymorphism was associated with an increased risk of prostate cancer. Among non-smokers, the A/A genotype was significantly more prevalent in prostate cancer patients than in controls. |
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| 言語 | en | |||||
| 内容記述 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | Citation: Yoshino Y, Takeuchi S, Katoh T, Kuroda Y. XPC intron11 C/A polymorphism as a risk factor for prostate cancer. Environ Health Prev Med. 2016 Mar;21(2):100-4. doi: 10.1007/s12199-015-0505-z. Epub 2016 Jan 8. PMID: 26745975; PMCID: PMC4771637. |
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| 言語 | en | |||||
| 書誌情報 |
en : Environmental Health and Preventive Medicine 巻 21, 号 2, p. 100-104, 発行日 2016-03 |
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| 出版者 | ||||||
| 出版者 | The Japanese Society for Hygiene | |||||
| 言語 | en | |||||
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| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 1342-078X | |||||
| DOI | ||||||
| 関連タイプ | isIdenticalTo | |||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | https://doi.org/10.1007/s12199-015-0505-z | |||||
| 著者版フラグ | ||||||
| 出版タイプ | NA | |||||
