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BCL11B is frequently downregulated in HTLV-1-infected T-cells through Tax-mediated proteasomal degradation
http://hdl.handle.net/10458/0002000457
http://hdl.handle.net/10458/0002000457bf4bafec-1ee8-475d-a28a-a597109a2c79
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2024-01-26 | |||||
| タイトル | ||||||
| タイトル | BCL11B is frequently downregulated in HTLV-1-infected T-cells through Tax-mediated proteasomal degradation | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| 著者 |
パーマタサリ, ハッピー クリーニア
× パーマタサリ, ハッピー クリーニア× Nakahata, Shingo× Ichikawa, Tomonaga× 森下, 和広 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Human T-cell leukemia virus type 1 (HTLV-1) is a causative agent of adult T-cell leukemia-lymphoma (ATLL). The HTLV-1-encoded protein Tax plays important roles in the proliferation of HTLV-1-infected T-cells by affecting cellular proteins. In this study, we showed that Tax transcriptionally and post-transcriptionally downregulates the expression of the tumor suppressor gene B-cell leukemia/lymphoma 11B (BCL11B), which encodes a lymphoid-related transcription factor. BCL11B expression was downregulated in HTLV-1-infected T-cell lines at the mRNA and protein levels, and forced expression of BCL11B suppressed the proliferation of these cells. The proteasomal inhibitor MG132 increased BCL11B expression in HTLV-1-infected cell lines, and colocalization of Tax with BCL11B was detected in the cytoplasm of HTLV-1-infected T-cells following MG132 treatment. shRNA knock-down of Tax expression also increased the expression of BCL11B in HTLV-1-infected cells. Moreover, we found that Tax physically binds to BCL11B protein and induces the polyubiquitination of BCL11B and proteasome-dependent degradation of BCL11B. Thus, inactivation of BCL11B by Tax protein may play an important role in the Tax-mediated leukemogenesis. | |||||
| 言語 | en | |||||
| 内容記述 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | Citation: Permatasari HK, Nakahata S, Ichikawa T, Morishita K. BCL11B is frequently downregulated in HTLV-1-infected T-cells through Tax-mediated proteasomal degradation. Biochem Biophys Res Commun. 2017 Aug 26;490(3):1086-1092. doi: 10.1016/j.bbrc.2017.06.172. Epub 2017 Jun 29. PMID: 28669733. |
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| 言語 | en | |||||
| 書誌情報 |
en : Biochemical and Biophysical Research Communications 巻 490, 号 3, p. 1086-1092, 発行日 2017-08-26 |
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| 出版者 | ||||||
| 出版者 | Elsevier | |||||
| 言語 | en | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 0006291X | |||||
| DOI | ||||||
| 関連タイプ | isVersionOf | |||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | https://doi.org/10.1016/j.bbrc.2017.06.172 | |||||
| 著者版フラグ | ||||||
| 出版タイプ | NA | |||||
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パーマタサリ, ハッピー クリーニア, Nakahata, Shingo, Ichikawa, Tomonaga, 森下, 和広, 2017, BCL11B is frequently downregulated in HTLV-1-infected T-cells through Tax-mediated proteasomal degradation: Elsevier, 1086–1092 p.
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