{"created":"2024-01-27T05:41:21.862355+00:00","id":2000457,"links":{},"metadata":{"_buckets":{"deposit":"d2823dd0-8fd6-494a-8ca0-405a4be498bf"},"_deposit":{"created_by":9,"id":"2000457","owner":"9","owners":[9],"pid":{"revision_id":0,"type":"depid","value":"2000457"},"status":"published"},"_oai":{"id":"oai:miyazaki-u.repo.nii.ac.jp:02000457","sets":["76","76:64"]},"author_link":["28614","21835","28014","28013"],"item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2017-08-26","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"3","bibliographicPageEnd":"1092","bibliographicPageStart":"1086","bibliographicVolumeNumber":"490","bibliographic_titles":[{"bibliographic_title":"Biochemical and Biophysical Research Communications","bibliographic_titleLang":"en"}]}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Human T-cell leukemia virus type 1 (HTLV-1) is a causative agent of adult T-cell leukemia-lymphoma (ATLL). The HTLV-1-encoded protein Tax plays important roles in the proliferation of HTLV-1-infected T-cells by affecting cellular proteins. In this study, we showed that Tax transcriptionally and post-transcriptionally downregulates the expression of the tumor suppressor gene B-cell leukemia/lymphoma 11B (BCL11B), which encodes a lymphoid-related transcription factor. BCL11B expression was downregulated in HTLV-1-infected T-cell lines at the mRNA and protein levels, and forced expression of BCL11B suppressed the proliferation of these cells. The proteasomal inhibitor MG132 increased BCL11B expression in HTLV-1-infected cell lines, and colocalization of Tax with BCL11B was detected in the cytoplasm of HTLV-1-infected T-cells following MG132 treatment. shRNA knock-down of Tax expression also increased the expression of BCL11B in HTLV-1-infected cells. Moreover, we found that Tax physically binds to BCL11B protein and induces the polyubiquitination of BCL11B and proteasome-dependent degradation of BCL11B. Thus, inactivation of BCL11B by Tax protein may play an important role in the Tax-mediated leukemogenesis.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10001_description_6":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"Citation:\nPermatasari HK, Nakahata S, Ichikawa T, Morishita K. BCL11B is frequently downregulated in HTLV-1-infected T-cells through Tax-mediated proteasomal degradation. Biochem Biophys Res Commun. 2017 Aug 26;490(3):1086-1092. doi: 10.1016/j.bbrc.2017.06.172. Epub 2017 Jun 29. PMID: 28669733.","subitem_description_language":"en","subitem_description_type":"Other"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Elsevier","subitem_publisher_language":"en"}]},"item_10001_relation_14":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.1016/j.bbrc.2017.06.172","subitem_relation_type_select":"DOI"}}]},"item_10001_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0006291X","subitem_source_identifier_type":"ISSN"}]},"item_10001_version_type_20":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_be7fb7dd8ff6fe43","subitem_version_type":"NA"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/"}],"affiliationNames":[{"affiliationName":"","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"Permatasari, Happy Kurnia  ","creatorNameLang":"en"},{"creatorName":"パーマタサリ, ハッピー クリーニア","creatorNameLang":"ja"},{"creatorName":"パーマタサリ, ハッピー クリーニア","creatorNameLang":"ja-Kana"}],"familyNames":[{"familyName":"Permatasari","familyNameLang":"en"},{"familyName":"パーマタサリ","familyNameLang":"ja"},{"familyName":"パーマタサリ","familyNameLang":"ja-Kana"}],"givenNames":[{"givenName":"Happy Kurnia  ","givenNameLang":"en"},{"givenName":"ハッピー クリーニア","givenNameLang":"ja"},{"givenName":"ハッピー クリーニア","givenNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"28614","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Nakahata, Shingo","creatorNameLang":"en"}],"familyNames":[{"familyName":"Nakahata","familyNameLang":"en"}],"givenNames":[{"givenName":"Shingo","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"28014","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ichikawa, Tomonaga","creatorNameLang":"en"}],"familyNames":[{"familyName":"Ichikawa","familyNameLang":"en"}],"givenNames":[{"givenName":"Tomonaga","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"28013","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Morishita, Kazuhiro","creatorNameLang":"en"},{"creatorName":"森下, 和広","creatorNameLang":"ja"},{"creatorName":"モリシタ, カズヒロ","creatorNameLang":"ja-Kana"}],"familyNames":[{"familyName":"Morishita","familyNameLang":"en"},{"familyName":"森下","familyNameLang":"ja"},{"familyName":"モリシタ","familyNameLang":"ja-Kana"}],"givenNames":[{"givenName":"Kazuhiro","givenNameLang":"en"},{"givenName":"和広","givenNameLang":"ja"},{"givenName":"カズヒロ","givenNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"21835","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"80260321","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=80260321"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"BCL11B is frequently downregulated in HTLV-1-infected T-cells through Tax-mediated proteasomal degradation","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"BCL11B is frequently downregulated in HTLV-1-infected T-cells through Tax-mediated proteasomal degradation","subitem_title_language":"en"}]},"item_type_id":"10001","owner":"9","path":["76","64"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2024-01-26"},"publish_date":"2024-01-26","publish_status":"0","recid":"2000457","relation_version_is_last":true,"title":["BCL11B is frequently downregulated in HTLV-1-infected T-cells through Tax-mediated proteasomal degradation"],"weko_creator_id":"9","weko_shared_id":-1},"updated":"2024-02-06T08:48:57.528986+00:00"}