WEKO3
アイテム
Neuropeptide S increases motor activity and thermogenesis in the rat through sympathetic activation
http://hdl.handle.net/10458/0002000396
http://hdl.handle.net/10458/0002000396e66b38a1-a4b7-4270-8b40-81f1f8637b1f
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2023-12-20 | |||||
| タイトル | ||||||
| タイトル | Neuropeptide S increases motor activity and thermogenesis in the rat through sympathetic activation | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| キーワード | Neuropeptide S | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| キーワード | Thermoregulation | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| キーワード | Sympathetic nervous system | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| キーワード | Energy expenditure | |||||
| 資源タイプ | ||||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| 著者 |
延生, 卓也
× 延生, 卓也× 中原, 桂子× 鈴木, 祥広× 村上, 昇 |
|||||
| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | The central role of neuropeptide S (NPS), identified as the endogenous ligand for GPR154, now named neuropeptide S receptor (NPSR), has not yet been fully clarified. We examined the central role of NPS for body temperature, energy expenditure, locomotor activity and adrenal hormone secretion in rats. Intracerebroventricular (icv) injection of NPS increased body temperature in a dose-dependent manner. Energy consumption and locomotor activity were also significantly increased by icv injection of NPS. In addition, icv injection of NPS increased the peripheral blood concentration of adrenalin and corticosterone. Pretreatment with the β1- and β2-adrenergic receptor blocker timolol inhibited the NPS-induced increase of body temperature. The expression of both NPS mRNA in the brainstem and NPSR mRNA in the hypothalamus showed a nocturnal rhythm with a peak occurring during the first half of the dark period. To examine whether the endogenous NPS is involved in regulation of body temperature, NPSR antagonist SHA68 was administered one hour after darkness. SHA68 attenuated the nocturnal rise of body temperature. These results suggest that NPS contributes to the regulation of the sympathetic nervous system. | |||||
| 言語 | en | |||||
| 内容記述 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | citation: Ensho T, Nakahara K, Suzuki Y, Murakami N. Neuropeptide S increases motor activity and thermogenesis in the rat through sympathetic activation. Neuropeptides. 2017 Oct;65:21-27. doi: 10.1016/j.npep.2017.04.005. Epub 2017 Apr 13. PMID: 28433253. |
|||||
| 言語 | en | |||||
| 書誌情報 |
en : Neuropeptides 巻 65, p. 21-27, 発行日 2017 |
|||||
| 出版者 | ||||||
| 出版者 | Elsevier | |||||
| 言語 | en | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 01434179 | |||||
| DOI | ||||||
| 関連タイプ | isVersionOf | |||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | https://doi.org/10.1016/j.npep.2017.04.005 | |||||
| 権利 | ||||||
| 言語 | en | |||||
| 権利情報 | © 2017 Elsevier Ltd. All rights reserved. | |||||
| 著者版フラグ | ||||||
| 出版タイプ | VoR | |||||
