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Arsenic acid inhibits proliferation of skin fibroblasts, and increases cellular senescence through ROS mediated MST1-FOXO signaling pathway
http://hdl.handle.net/10458/0002000393
http://hdl.handle.net/10458/000200039308adb610-8b17-47db-9117-c0ab0afe3401
| 名前 / ファイル | ライセンス | アクション |
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article (1.9 MB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||||||||||||||||||
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| 公開日 | 2023-12-19 | |||||||||||||||||||||
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| タイトル | Arsenic acid inhibits proliferation of skin fibroblasts, and increases cellular senescence through ROS mediated MST1-FOXO signaling pathway | |||||||||||||||||||||
| 言語 | en | |||||||||||||||||||||
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| 言語 | eng | |||||||||||||||||||||
| キーワード | ||||||||||||||||||||||
| 言語 | en | |||||||||||||||||||||
| 主題Scheme | Other | |||||||||||||||||||||
| キーワード | Arsenic acid | |||||||||||||||||||||
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| 言語 | en | |||||||||||||||||||||
| 主題Scheme | Other | |||||||||||||||||||||
| キーワード | Cell proliferation | |||||||||||||||||||||
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| 言語 | en | |||||||||||||||||||||
| 主題Scheme | Other | |||||||||||||||||||||
| キーワード | Oxidative stress | |||||||||||||||||||||
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| 言語 | en | |||||||||||||||||||||
| 主題Scheme | Other | |||||||||||||||||||||
| キーワード | Mammalian Ste20-like protein kinase 1 | |||||||||||||||||||||
| キーワード | ||||||||||||||||||||||
| 言語 | en | |||||||||||||||||||||
| 主題Scheme | Other | |||||||||||||||||||||
| キーワード | Forkhead box O transcription factors | |||||||||||||||||||||
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| 言語 | en | |||||||||||||||||||||
| 主題Scheme | Other | |||||||||||||||||||||
| キーワード | Cellular senescence | |||||||||||||||||||||
| 資源タイプ | ||||||||||||||||||||||
| 資源タイプ | journal article | |||||||||||||||||||||
| 著者 |
山口, 優也
× 山口, 優也× マドゥエスタ, ハリーシャクマール
WEKO
7810
× Madhyastha, Radha× チヨウジヨウフ, ナランツオツク
WEKO
26967
× 菱川, 善隆× Pengjam, Yutthana× 中島, 融一× 丸山, 眞杉 |
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| 抄録 | ||||||||||||||||||||||
| 内容記述タイプ | Abstract | |||||||||||||||||||||
| 内容記述 | Arsenic exposure through drinking water is a major public health problem. It causes a number of toxic effects on skin. Arsenic has been reported to inhibit cell proliferation in in vitro conditions. However, reports about the molecular mechanisms are limited. Here, we investigated the mechanism involved in arsenic acid-mediated inhibition of cell proliferation using mouse skin fibroblast cell line. The present study found that 10 ppm arsenic acid inhibited cell proliferation, without any effect on cell death. Arsenic acid induced the generation of reactive oxygen species (ROS), resulting in oxidative stress to DNA. It also activated the mammalian Ste20-like protein kinase 1 (MST1); however the serine/threonine kinase Akt was downregulated. Forkhead box O (FOXO) transcription factors are activated through phosphorylation by MST1 under stress conditions. They are inhibited by phosphorylation by Akt through external and internal stimuli. Activation of FOXOs results in their nuclear localization, followed by an increase in transcriptional activity. Our results showed that arsenic induced the nuclear translocation of FOXO1 and FOXO3a, and altered the cell cycle, with cells accumulating at the G2/M phase. These effects caused cellular senescence. Taken together, our results indicate that arsenic acid inhibited cell proliferation through cellular senescence process regulated by MST1-FOXO signaling pathway. | |||||||||||||||||||||
| 言語 | en | |||||||||||||||||||||
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| 内容記述タイプ | Other | |||||||||||||||||||||
| 内容記述 | Citation: Yamaguchi Y, Madhyastha H, Madhyastha R, Choijookhuu N, Hishikawa Y, Pengjam Y, Nakajima Y, Maruyama M. Arsenic acid inhibits proliferation of skin fibroblasts, and increases cellular senescence through ROS mediated MST1-FOXO signaling pathway. J Toxicol Sci. 2016 Feb;41(1):105-13. doi: 10.2131/jts.41.105. PMID: 26763397. |
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| 言語 | en | |||||||||||||||||||||
| 書誌情報 |
en : The Journal of Toxicological Sciences 巻 41, 号 1, p. 105-113, 発行日 2016-02-01 |
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| 出版者 | Japanese Society of Toxicology | |||||||||||||||||||||
| 言語 | en | |||||||||||||||||||||
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| 収録物識別子タイプ | ISSN | |||||||||||||||||||||
| 収録物識別子 | 0388-1350 | |||||||||||||||||||||
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| 関連タイプ | isVersionOf | |||||||||||||||||||||
| 識別子タイプ | DOI | |||||||||||||||||||||
| 関連識別子 | https://doi.org/10.2131/jts.41.105 | |||||||||||||||||||||
| 権利 | ||||||||||||||||||||||
| 言語 | en | |||||||||||||||||||||
| 権利情報 | © 2016 The Japanese Society of Toxicology | |||||||||||||||||||||
| 著者版フラグ | ||||||||||||||||||||||
| 出版タイプ | VoR | |||||||||||||||||||||
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山口, 優也, マドゥエスタ, ハリーシャクマール, Madhyastha, Radha, チヨウジヨウフ, ナランツオツク, 菱川, 善隆, Pengjam, Yutthana, 中島, 融一, 丸山, 眞杉, 2016, Arsenic acid inhibits proliferation of skin fibroblasts, and increases cellular senescence through ROS mediated MST1-FOXO signaling pathway: Japanese Society of Toxicology, 105–113 p.
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