{"created":"2023-12-19T07:44:10.620412+00:00","id":2000393,"links":{},"metadata":{"_buckets":{"deposit":"e462f047-ee0d-4adf-8fd2-9031149a68fb"},"_deposit":{"created_by":9,"id":"2000393","owner":"9","owners":[9],"pid":{"revision_id":0,"type":"depid","value":"2000393"},"status":"published"},"_oai":{"id":"oai:miyazaki-u.repo.nii.ac.jp:02000393","sets":["76","76:64"]},"author_link":["26963","26967","26978","2630","7810","34189","26966","32287"],"item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2016-02-01","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1","bibliographicPageEnd":"113","bibliographicPageStart":"105","bibliographicVolumeNumber":"41","bibliographic_titles":[{"bibliographic_title":"The Journal of Toxicological Sciences","bibliographic_titleLang":"en"}]}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Arsenic exposure through drinking water is a major public health problem. It causes a number of toxic effects on skin. Arsenic has been reported to inhibit cell proliferation in in vitro conditions. However, reports about the molecular mechanisms are limited. Here, we investigated the mechanism involved in arsenic acid-mediated inhibition of cell proliferation using mouse skin fibroblast cell line. The present study found that 10 ppm arsenic acid inhibited cell proliferation, without any effect on cell death. Arsenic acid induced the generation of reactive oxygen species (ROS), resulting in oxidative stress to DNA. It also activated the mammalian Ste20-like protein kinase 1 (MST1); however the serine/threonine kinase Akt was downregulated. Forkhead box O (FOXO) transcription factors are activated through phosphorylation by MST1 under stress conditions. They are inhibited by phosphorylation by Akt through external and internal stimuli. Activation of FOXOs results in their nuclear localization, followed by an increase in transcriptional activity. Our results showed that arsenic induced the nuclear translocation of FOXO1 and FOXO3a, and altered the cell cycle, with cells accumulating at the G2/M phase. These effects caused cellular senescence. Taken together, our results indicate that arsenic acid inhibited cell proliferation through cellular senescence process regulated by MST1-FOXO signaling pathway.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10001_description_6":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"Citation:\nYamaguchi Y, Madhyastha H, Madhyastha R, Choijookhuu N, Hishikawa Y, Pengjam Y, Nakajima Y, Maruyama M. Arsenic acid inhibits proliferation of skin fibroblasts, and increases cellular senescence through ROS mediated MST1-FOXO signaling pathway. J Toxicol Sci. 2016 Feb;41(1):105-13. doi: 10.2131/jts.41.105. PMID: 26763397.","subitem_description_language":"en","subitem_description_type":"Other"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Japanese Society of Toxicology","subitem_publisher_language":"en"}]},"item_10001_relation_14":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.2131/jts.41.105","subitem_relation_type_select":"DOI"}}]},"item_10001_rights_15":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"© 2016 The Japanese Society of Toxicology","subitem_rights_language":"en"}]},"item_10001_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0388-1350","subitem_source_identifier_type":"ISSN"}]},"item_10001_version_type_20":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"山口, 優也","creatorNameLang":"ja"},{"creatorName":"ヤマグチ, ユウヤ","creatorNameLang":"ja-Kana"},{"creatorName":"Yamaguchi, Yuya","creatorNameLang":"en"}],"familyNames":[{"familyName":"山口","familyNameLang":"ja"},{"familyName":"ヤマグチ","familyNameLang":"ja-Kana"},{"familyName":"Yamaguchi","familyNameLang":"en"}],"givenNames":[{"givenName":"優也","givenNameLang":"ja"},{"givenName":"ユウヤ","givenNameLang":"ja-Kana"},{"givenName":"Yuya","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"26963","nameIdentifierScheme":"WEKO"}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"0000000106573887","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/0000000106573887"}],"affiliationNames":[{"affiliationName":"宮崎大学","affiliationNameLang":"ja"},{"affiliationName":"University of Miyazaki","affiliationNameLang":"en"}]}],"creatorNames":[{"creatorName":"Madhyastha, Harishkumar","creatorNameLang":"en"},{"creatorName":"マドゥエスタ, ハリーシャクマール","creatorNameLang":"ja"},{"creatorName":"マドゥエスタ, ハリーシャクマール","creatorNameLang":"ja-Kana"},{"creatorName":"Madhyastha, Harish Kumar","creatorNameLang":"en"}],"familyNames":[{"familyName":"Madhyastha","familyNameLang":"en"},{"familyName":"マドゥエスタ","familyNameLang":"ja"},{"familyName":"マドゥエスタ","familyNameLang":"ja-Kana"},{"familyName":"Madhyastha","familyNameLang":"en"}],"givenNames":[{"givenName":"Harishkumar","givenNameLang":"en"},{"givenName":"ハリーシャクマール","givenNameLang":"ja"},{"givenName":"ハリーシャクマール","givenNameLang":"ja-Kana"},{"givenName":"Harish Kumar","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"7810","nameIdentifierScheme":"WEKO"}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"0000000106573887","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/0000000106573887"}],"affiliationNames":[{"affiliationName":"宮崎大学","affiliationNameLang":"ja"},{"affiliationName":"University of Miyazaki","affiliationNameLang":"en"}]}],"creatorNames":[{"creatorName":"Madhyastha, Radha","creatorNameLang":"en"},{"creatorName":"マドゥエスタ, ラダ","creatorNameLang":"ja-Kana"}],"familyNames":[{"familyName":"Madhyastha","familyNameLang":"en"},{"familyName":"マドゥエスタ","familyNameLang":"ja-Kana"}],"givenNames":[{"givenName":"Radha","givenNameLang":"en"},{"givenName":"ラダ","givenNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"26966","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Choijookhuu, Narantsog","creatorNameLang":"en"},{"creatorName":"チヨウジヨウフ, ナランツオツク","creatorNameLang":"ja"},{"creatorName":"チヨウジヨウフ, ナランツオツク","creatorNameLang":"ja-Kana"}],"familyNames":[{"familyName":"Choijookhuu","familyNameLang":"en"},{"familyName":"チヨウジヨウフ","familyNameLang":"ja"},{"familyName":"チヨウジヨウフ","familyNameLang":"ja-Kana"}],"givenNames":[{"givenName":"Narantsog","givenNameLang":"en"},{"givenName":"ナランツオツク","givenNameLang":"ja"},{"givenName":"ナランツオツク","givenNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"26967","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"90640962","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=90640962"}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"0000000106573887","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"https://isni.org/isni/0000000106573887"}],"affiliationNames":[{"affiliationName":"宮崎大学","affiliationNameLang":"ja"},{"affiliationName":"University of Miyazaki","affiliationNameLang":"en"}]}],"creatorNames":[{"creatorName":"菱川, 善隆","creatorNameLang":"ja"},{"creatorName":"ヒシカワ, ヨシタカ","creatorNameLang":"ja-Kana"},{"creatorName":"Hishikawa, Yoshitaka","creatorNameLang":"en"}],"familyNames":[{"familyName":"菱川","familyNameLang":"ja"},{"familyName":"ヒシカワ","familyNameLang":"ja-Kana"},{"familyName":"Hishikawa","familyNameLang":"en"}],"givenNames":[{"givenName":"善隆","givenNameLang":"ja"},{"givenName":"ヨシタカ","givenNameLang":"ja-Kana"},{"givenName":"Yoshitaka","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"34189","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"60304276","nameIdentifierScheme":"e-Rad_Researcher","nameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=60304276"}]},{"creatorNames":[{"creatorName":"Pengjam, Yutthana","creatorNameLang":"en"}],"familyNames":[{"familyName":"Pengjam","familyNameLang":"en"}],"givenNames":[{"givenName":"Yutthana","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"26978","nameIdentifierScheme":"WEKO"}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"0000000106573887","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"https://isni.org/isni/0000000106573887"}],"affiliationNames":[{"affiliationName":"宮崎大学","affiliationNameLang":"ja"},{"affiliationName":"University of Miyazaki","affiliationNameLang":"en"}]}],"creatorNames":[{"creatorName":"中島, 融一","creatorNameLang":"ja"},{"creatorName":"ナカジマ, ユウイチ","creatorNameLang":"ja-Kana"},{"creatorName":"Nakajima, Yuichi","creatorNameLang":"en"}],"familyNames":[{"familyName":"中島","familyNameLang":"ja"},{"familyName":"ナカジマ","familyNameLang":"ja-Kana"},{"familyName":"Nakajima","familyNameLang":"en"}],"givenNames":[{"givenName":"融一","givenNameLang":"ja"},{"givenName":"ユウイチ","givenNameLang":"ja-Kana"},{"givenName":"Yuichi","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"32287","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"80372796","nameIdentifierScheme":"e-Rad_Researcher","nameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=80372796"}]},{"creatorNames":[{"creatorName":"Maruyama, Masugi","creatorNameLang":"en"},{"creatorName":"丸山, 眞杉","creatorNameLang":"ja"},{"creatorName":"マルヤマ, マスギ","creatorNameLang":"ja-Kana"}],"familyNames":[{"familyName":"Maruyama","familyNameLang":"en"},{"familyName":"丸山","familyNameLang":"ja"},{"familyName":"マルヤマ","familyNameLang":"ja-Kana"}],"givenNames":[{"givenName":"Masugi","givenNameLang":"en"},{"givenName":"眞杉","givenNameLang":"ja"},{"givenName":"マスギ","givenNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"2630","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2023-12-19"}],"filename":"ronbun.pdf","filesize":[{"value":"1.9 MB"}],"format":"application/pdf","licensetype":"license_note","url":{"label":"article","objectType":"fulltext","url":"https://miyazaki-u.repo.nii.ac.jp/record/2000393/files/ronbun.pdf"},"version_id":"ff520316-7aea-4edc-9b46-3c8f7ce21663"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Arsenic acid","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Cell proliferation","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Oxidative stress","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Mammalian Ste20-like protein kinase 1","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Forkhead box O transcription factors","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Cellular senescence","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Arsenic acid inhibits proliferation of skin fibroblasts, and increases cellular senescence through ROS mediated MST1-FOXO signaling pathway","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Arsenic acid inhibits proliferation of skin fibroblasts, and increases cellular senescence through ROS mediated MST1-FOXO signaling pathway","subitem_title_language":"en"}]},"item_type_id":"10001","owner":"9","path":["76","64"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2023-12-19"},"publish_date":"2023-12-19","publish_status":"0","recid":"2000393","relation_version_is_last":true,"title":["Arsenic acid inhibits proliferation of skin fibroblasts, and increases cellular senescence through ROS mediated MST1-FOXO signaling pathway"],"weko_creator_id":"9","weko_shared_id":-1},"updated":"2025-01-17T02:46:35.267840+00:00"}