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Human liver‐expressed antimicrobial peptide 2 elevation in the cerebrospinal fluid in bacterial meningitis
http://hdl.handle.net/10458/0002000310
http://hdl.handle.net/10458/0002000310dd06f01e-30bb-475a-b7de-9ed00af320c0
| 名前 / ファイル | ライセンス | アクション |
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本文 (349 KB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||
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| 公開日 | 2023-11-07 | |||||
| タイトル | ||||||
| タイトル | Human liver‐expressed antimicrobial peptide 2 elevation in the cerebrospinal fluid in bacterial meningitis | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| キーワード | bacterial meningitis | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| キーワード | cerebrospinal fluid | |||||
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| 言語 | en | |||||
| 主題Scheme | Other | |||||
| キーワード | cross-sectional study | |||||
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| 言語 | en | |||||
| 主題Scheme | Other | |||||
| キーワード | enzyme-linked immunosorbent assay | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| キーワード | liver-expressed antimicrobial peptide 2 | |||||
| 資源タイプ | ||||||
| 資源タイプ | journal article | |||||
| 著者 |
酒井, 克也
× 酒井, 克也× 塩見, 一剛× Mochizuki, Hitoshi× イスラム, エムディ ヌルル× 鍋倉, 弘樹× Tanida, Ryota× 迫田, 秀之× 中里, 雅光 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Objective: To study the presence of liver-expressed antimicrobial peptide 2 (LEAP2) in human cerebrospinal fluid (CSF) and to measure its concentrations in neurologicaldisorders. Materials & Methods: We identified the presence of LEAP2 in human CSF by chro-matographic analysis and a LEAP2-specific enzyme immunoassay. We measured LEAP2 concentrations in the CSF of 35 patients with neurological disorders. Results: CSF LEAP2 concentrations in the bacterial meningitis group (mean ±SD, 9. 32± 3.76 ng/ml) were significantly higher (p< .05) than those in the other four groups (psychosomatic disorder, 0.56± 0.15 ng/ml; peripheral autoimmune dis-ease, 1.00 ± 0.60 ng/ml; multiple sclerosis, 0.62± 0.30 ng/ml; aseptic meningitis, 1.59± 0.69 ng/ml). Conclusions: This is the first study to identify the presence of human LEAP2 in the CSF. Levels of LEAP2 were increased in the CSF of patients with bacterial meningitis. LEAP2 may have potential as a biomarker for bacterial meningitis. |
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| 言語 | en | |||||
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| 内容記述タイプ | Other | |||||
| 内容記述 | Citation: Sakai K, Shiomi K, Mochizuki H, Islam MN, Nabekura H, Tanida R, Sakoda H, Nakazato M. Human liver-expressed antimicrobial peptide 2 elevation in the cerebrospinal fluid in bacterial meningitis. Brain Behav. 2021 May;11(5):e02111. doi: 10.1002/brb3.2111. Epub 2021 Apr 3. PMID: 33811478; PMCID: PMC8119843. |
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| 言語 | en | |||||
| 書誌情報 |
en : Brain and Behavior 巻 11, 号 5, 発行日 2021-04-03 |
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| 出版者 | ||||||
| 出版者 | Wiley | |||||
| 言語 | en | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 2162-3279 | |||||
| DOI | ||||||
| 関連タイプ | isVersionOf | |||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | https://doi.org/10.1002/brb3.2111 | |||||
| 権利 | ||||||
| 言語 | en | |||||
| 権利情報 | © 2021 The Authors. Brain and Behavior published by Wiley Periodicals LLC1Division of Neurology, Respirology, Endocrinology and Metabolism, Department of Internal Medicine, Faculty of Medicine, University of Miyazaki, Miyazaki, Japan2Department of Endocrinology and Metabolism, Kanazawa University Graduate School of Medical Sciences, Kanazawa, JapanCorrespondenceMasamitsu Nakazato, Division of Neurology, Respirology, Endocrinology and Metabolism, Department of Internal Medicine, Faculty of Medicine, University of Miyazaki, Miyazaki, 5200 Kihara, Kiyotake, Miyazaki 889-1692, Japan.Email: nakazato@med.miyiazaki-u.ac.jpFunding informationJapan Foundation for Aging and Health (Hideyuki Sakoda); Clinical Research from Miyazaki University Hospital (Katsuya Sakai)AbstractObjective: To study the presence of liver-expressed antimicrobial peptide 2 (LEAP2) in human cerebrospinal fluid (CSF) and to measure its concentrations in neurologicaldisorders.Materials & Methods: We identified the presence of LEAP2 in human CSF by chro-matographic analysis and a LEAP2-specific enzyme immunoassay. We measured LEAP2 concentrations in the CSF of 35 patients with neurological disorders.Results: CSF LEAP2 concentrations in the bacterial meningitis group (mean ±SD, 9. 32± 3.76 ng/ml) were significantly higher (p< .05) than those in the other four groups (psychosomatic disorder, 0.56± 0.15 ng/ml; peripheral autoimmune dis-ease, 1.00 ± 0.60 ng/ml; multiple sclerosis, 0.62± 0.30 ng/ml; aseptic meningitis, 1.59± 0.69 ng/ml).Conclusions: This is the first study to identify the presence of human LEAP2 in the CSF. Levels of LEAP2 were increased in the CSF of patients with bacterial meningitis. LEAP2 may have potential as a biomarker for bacterial meningitis.KEYWORDSbacterial meningitis, cerebrospinal fluid, cross-sectional study, enzyme-linked immunosorbent assay, liver-expressed antimicrobial peptide 2 | |||||
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| 出版タイプ | VoR | |||||
