{"created":"2023-11-07T08:44:45.452891+00:00","id":2000310,"links":{},"metadata":{"_buckets":{"deposit":"f8812658-8f3a-40cc-b87e-5d4eff8f0c2c"},"_deposit":{"created_by":9,"id":"2000310","owner":"9","owners":[9],"pid":{"revision_id":0,"type":"depid","value":"2000310"},"status":"published"},"_oai":{"id":"oai:miyazaki-u.repo.nii.ac.jp:02000310","sets":["76","76:64"]},"author_link":["34567","34802","33796","32281","21757","33792","26397","21854"],"item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2021-04-03","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"5","bibliographicVolumeNumber":"11","bibliographic_titles":[{"bibliographic_title":"Brain and Behavior","bibliographic_titleLang":"en"}]}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Objective: To study the presence of liver-expressed antimicrobial peptide 2 (LEAP2) in  human cerebrospinal fluid (CSF) and    to  measure its   concentrations in  neurologicaldisorders.\nMaterials & Methods: We    identified the    presence of   LEAP2 in   human CSF by   chro-matographic  analysis  and  a  LEAP2-specific  enzyme  immunoassay.  We  measured  LEAP2 concentrations in the CSF of 35 patients with neurological disorders.\nResults: CSF LEAP2 concentrations in   the    bacterial meningitis group (mean ±SD, 9. 32±  3.76  ng/ml)  were  significantly  higher  (p<  .05)  than  those  in  the  other  four  groups  (psychosomatic  disorder,  0.56±  0.15  ng/ml;  peripheral  autoimmune  dis-ease,  1.00  ±  0.60  ng/ml;  multiple  sclerosis,  0.62±  0.30  ng/ml;  aseptic  meningitis,  1.59± 0.69 ng/ml).\nConclusions: This is the first study to identify the presence of human LEAP2 in the CSF. Levels of   LEAP2 were increased in   the    CSF of   patients with bacterial meningitis. LEAP2 may have potential as a biomarker for bacterial meningitis.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10001_description_6":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"Citation:\nSakai K, Shiomi K, Mochizuki H, Islam MN, Nabekura H, Tanida R, Sakoda H, Nakazato M. Human liver-expressed antimicrobial peptide 2 elevation in the cerebrospinal fluid in bacterial meningitis. Brain Behav. 2021 May;11(5):e02111. doi: 10.1002/brb3.2111. Epub 2021 Apr 3. PMID: 33811478; PMCID: PMC8119843.","subitem_description_language":"en","subitem_description_type":"Other"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Wiley","subitem_publisher_language":"en"}]},"item_10001_relation_14":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.1002/brb3.2111","subitem_relation_type_select":"DOI"}}]},"item_10001_rights_15":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"© 2021 The Authors. Brain and Behavior published by Wiley Periodicals LLC1Division of Neurology, Respirology, Endocrinology and Metabolism, Department of Internal Medicine, Faculty of Medicine, University of Miyazaki, Miyazaki, Japan2Department of Endocrinology and Metabolism, Kanazawa University Graduate School of Medical Sciences, Kanazawa, JapanCorrespondenceMasamitsu Nakazato, Division of Neurology, Respirology, Endocrinology and Metabolism, Department of Internal Medicine, Faculty of Medicine, University of Miyazaki, Miyazaki, 5200 Kihara, Kiyotake, Miyazaki 889-1692, Japan.Email: nakazato@med.miyiazaki-u.ac.jpFunding informationJapan Foundation for Aging and Health (Hideyuki Sakoda); Clinical Research from Miyazaki University Hospital (Katsuya Sakai)AbstractObjective: To study the presence of liver-expressed antimicrobial peptide 2 (LEAP2) in  human cerebrospinal fluid (CSF) and    to  measure its   concentrations in  neurologicaldisorders.Materials & Methods: We    identified the    presence of   LEAP2 in   human CSF by   chro-matographic  analysis  and  a  LEAP2-specific  enzyme  immunoassay.  We  measured  LEAP2 concentrations in the CSF of 35 patients with neurological disorders.Results: CSF LEAP2 concentrations in   the    bacterial meningitis group (mean ±SD, 9. 32±  3.76  ng/ml)  were  significantly  higher  (p<  .05)  than  those  in  the  other  four  groups  (psychosomatic  disorder,  0.56±  0.15  ng/ml;  peripheral  autoimmune  dis-ease,  1.00  ±  0.60  ng/ml;  multiple  sclerosis,  0.62±  0.30  ng/ml;  aseptic  meningitis,  1.59± 0.69 ng/ml).Conclusions: This is the first study to identify the presence of human LEAP2 in the CSF. Levels of   LEAP2 were increased in   the    CSF of   patients with bacterial meningitis. LEAP2 may have potential as a biomarker for bacterial meningitis.KEYWORDSbacterial meningitis, cerebrospinal fluid, cross-sectional study, enzyme-linked immunosorbent assay, liver-expressed antimicrobial peptide 2","subitem_rights_language":"en"}]},"item_10001_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"2162-3279","subitem_source_identifier_type":"ISSN"}]},"item_10001_version_type_20":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"0000000106573887","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"https://isni.org/isni/0000000106573887"}],"affiliationNames":[{"affiliationName":"宮崎大学","affiliationNameLang":"ja"},{"affiliationName":"University of Miyazaki","affiliationNameLang":"en"}]}],"creatorNames":[{"creatorName":"酒井, 克也","creatorNameLang":"ja"},{"creatorName":"サカイ, カツヤ","creatorNameLang":"ja-Kana"},{"creatorName":"Sakai, 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