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Essential role of submandibular lymph node dendritic cells in protective sublingual immunotherapy against murine allergy
http://hdl.handle.net/10458/0002000185
http://hdl.handle.net/10458/0002000185a2119ba3-d9a5-43a0-b7ba-30faa83ecb49
| 名前 / ファイル | ライセンス | アクション |
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本文 (3.3 MB)
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Supplementary Information (4 MB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||||||||||||
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| 公開日 | 2023-10-30 | |||||||||||||||
| タイトル | ||||||||||||||||
| タイトル | Essential role of submandibular lymph node dendritic cells in protective sublingual immunotherapy against murine allergy | |||||||||||||||
| 言語 | en | |||||||||||||||
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| 言語 | eng | |||||||||||||||
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| 資源タイプ | journal article | |||||||||||||||
| 著者 |
宮永, 宜明
× 宮永, 宜明× 高木, 秀明× 宇都, 倫史× 深谷, 知宏× 奈須, 遵太× 福井, 丈仁× 西川, 陽太郎× Sparwasser, Tim
× チヨウジヨウフ, ナランツオツク
WEKO
26967
× 菱川, 善隆× 中村, 雄× 東野, 哲也× 佐藤, 克明 |
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| 内容記述タイプ | Abstract | |||||||||||||||
| 内容記述 | While sublingual immunotherapy (SLIT) is known as an allergen-specific treatment for type-1 allergies, how it controls allergic pathogenesis remains unclear. Here, we show the prerequisite role of conventional dendritic cells in submandibular lymph nodes (ManLNs) in the effectiveness of SLIT for the treatment of allergic disorders in mice. Deficiency of conventional dendritic cells or CD4+Foxp3+ regulatory T (Treg) cells abrogates the protective effect of SLIT against allergic disorders. Furthermore, sublingual antigenic application primarily induces antigen-specific CD4+Foxp3+ Treg cells in draining ManLNs, in which it is severely impaired in the absence of cDCs. In ManLNs, migratory CD11b+ cDCs are superior to other conventional dendritic cell subsets for the generation of antigen-specific CD4+Foxp3+ Treg cells, which is reflected by their dominancy in the tolerogenic features to favor this program. Thus, ManLNs are privileged sites in triggering mucosal tolerance mediating protect effect of SLIT on allergic disorders that requires a tolerogenesis of migratory CD11b+ conventional dendritic cells. | |||||||||||||||
| 言語 | en | |||||||||||||||
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| 内容記述タイプ | Other | |||||||||||||||
| 内容記述 | Citation: Miyanaga N, Takagi H, Uto T, Fukaya T, Nasu J, Fukui T, Nishikawa Y, Sparwasser T, Choijookhuu N, Hishikawa Y, Nakamura T, Tono T, Sato K. Essential role of submandibular lymph node dendritic cells in protective sublingual immunotherapy against murine allergy. Commun Biol. 2020 Dec 7;3(1):742. doi: 10.1038/s42003-020-01466-3. PMID: 33288832; PMCID: PMC7721894. |
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| 言語 | en | |||||||||||||||
| 書誌情報 |
en : Communications Biology 巻 3, 号 1, p. 742 (2020), 発行日 2020-12-07 |
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| 出版者 | ||||||||||||||||
| 出版者 | Springer Nature | |||||||||||||||
| 言語 | en | |||||||||||||||
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| 関連タイプ | isVersionOf | |||||||||||||||
| 識別子タイプ | DOI | |||||||||||||||
| 関連識別子 | https://doi.org/10.1038/s42003-020-01466-3 | |||||||||||||||
| 権利 | ||||||||||||||||
| 言語 | en | |||||||||||||||
| 権利情報 | © The Author(s) 2020 | |||||||||||||||
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| 出版タイプ | VoR | |||||||||||||||
