{"created":"2023-10-30T05:46:08.178763+00:00","id":2000185,"links":{},"metadata":{"_buckets":{"deposit":"f53dad44-9a57-48aa-a1eb-34ceebebbb08"},"_deposit":{"created_by":9,"id":"2000185","owner":"9","owners":[9],"pid":{"revision_id":0,"type":"depid","value":"2000185"},"status":"published"},"_oai":{"id":"oai:miyazaki-u.repo.nii.ac.jp:02000185","sets":["76","76:64"]},"author_link":["34349","26967","30111","30184","30180","34353","34572","30185","9835","34189","34707","30105"],"control_number":"2000185","item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2020-12-07","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1","bibliographicPageStart":"742 (2020)","bibliographicVolumeNumber":"3","bibliographic_titles":[{"bibliographic_title":"Communications Biology","bibliographic_titleLang":"en"}]}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"While sublingual immunotherapy (SLIT) is known as an allergen-specific treatment for type-1 allergies, how it controls allergic pathogenesis remains unclear. Here, we show the prerequisite role of conventional dendritic cells in submandibular lymph nodes (ManLNs) in the effectiveness of SLIT for the treatment of allergic disorders in mice. Deficiency of conventional dendritic cells or CD4+Foxp3+ regulatory T (Treg) cells abrogates the protective effect of SLIT against allergic disorders. Furthermore, sublingual antigenic application primarily induces antigen-specific CD4+Foxp3+ Treg cells in draining ManLNs, in which it is severely impaired in the absence of cDCs. In ManLNs, migratory CD11b+ cDCs are superior to other conventional dendritic cell subsets for the generation of antigen-specific CD4+Foxp3+ Treg cells, which is reflected by their dominancy in the tolerogenic features to favor this program. Thus, ManLNs are privileged sites in triggering mucosal tolerance mediating protect effect of SLIT on allergic disorders that requires a tolerogenesis of migratory CD11b+ conventional dendritic cells.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10001_description_6":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"Citation:\nMiyanaga N, Takagi H, Uto T, Fukaya T, Nasu J, Fukui T, Nishikawa Y, Sparwasser T, Choijookhuu N, Hishikawa Y, Nakamura T, Tono T, Sato K. Essential role of submandibular lymph node dendritic cells in protective sublingual immunotherapy against murine allergy. Commun Biol. 2020 Dec 7;3(1):742. doi: 10.1038/s42003-020-01466-3. PMID: 33288832; PMCID: PMC7721894.","subitem_description_language":"en","subitem_description_type":"Other"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Springer Nature","subitem_publisher_language":"en"}]},"item_10001_relation_14":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.1038/s42003-020-01466-3","subitem_relation_type_select":"DOI"}}]},"item_10001_rights_15":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"© The Author(s) 2020","subitem_rights_language":"en"}]},"item_10001_version_type_20":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Miyanaga, Noriaki","creatorNameLang":"en"},{"creatorName":"宮永, 宜明","creatorNameLang":"ja"},{"creatorName":"ミヤナガ, ノリアキ","creatorNameLang":"ja-Kana"}],"familyNames":[{"familyName":"Miyanaga","familyNameLang":"en"},{"familyName":"宮永","familyNameLang":"ja"},{"familyName":"ミヤナガ","familyNameLang":"ja-Kana"}],"givenNames":[{"givenName":"Noriaki","givenNameLang":"en"},{"givenName":"宜明","givenNameLang":"ja"},{"givenName":"ノリアキ","givenNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"34353","nameIdentifierScheme":"WEKO"}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/"}],"affiliationNames":[{"affiliationName":"","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"Takagi, Hideaki","creatorNameLang":"en"},{"creatorName":"高木, 秀明","creatorNameLang":"ja"},{"creatorName":"タカギ, ヒデアキ","creatorNameLang":"ja-Kana"}],"familyNames":[{"familyName":"Takagi","familyNameLang":"en"},{"familyName":"高木","familyNameLang":"ja"},{"familyName":"タカギ","familyNameLang":"ja-Kana"}],"givenNames":[{"givenName":"Hideaki","givenNameLang":"en"},{"givenName":"秀明","givenNameLang":"ja"},{"givenName":"ヒデアキ","givenNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"30105","nameIdentifierScheme":"WEKO"}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"0000000106573887","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"https://isni.org/isni/0000000106573887"}],"affiliationNames":[{"affiliationName":"宮崎大学","affiliationNameLang":"ja"},{"affiliationName":"University of Miyazaki","affiliationNameLang":"en"}]}],"creatorNames":[{"creatorName":"宇都, 倫史","creatorNameLang":"ja"},{"creatorName":"ウト, トモフミ","creatorNameLang":"ja-Kana"},{"creatorName":"Uto, Tomofumi","creatorNameLang":"en"}],"familyNames":[{"familyName":"宇都","familyNameLang":"ja"},{"familyName":"ウト","familyNameLang":"ja-Kana"},{"familyName":"Uto","familyNameLang":"en"}],"givenNames":[{"givenName":"倫史","givenNameLang":"ja"},{"givenName":"トモフミ","givenNameLang":"ja-Kana"},{"givenName":"Tomofumi","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"30185","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"10624653","nameIdentifierScheme":"e-Rad_Researcher","nameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=10624653"}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"0000000106573887","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"https://isni.org/isni/0000000106573887"}],"affiliationNames":[{"affiliationName":"宮崎大学","affiliationNameLang":"ja"},{"affiliationName":"University of Miyazaki","affiliationNameLang":"en"}]}],"creatorNames":[{"creatorName":"深谷, 知宏","creatorNameLang":"ja"},{"creatorName":"フカヤ, トモヒロ","creatorNameLang":"ja-Kana"},{"creatorName":"Fukaya, Tomohiro","creatorNameLang":"en"}],"familyNames":[{"familyName":"深谷","familyNameLang":"ja"},{"familyName":"フカヤ","familyNameLang":"ja-Kana"},{"familyName":"Fukaya","familyNameLang":"en"}],"givenNames":[{"givenName":"知宏","givenNameLang":"ja"},{"givenName":"トモヒロ","givenNameLang":"ja-Kana"},{"givenName":"Tomohiro","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"30184","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"20624323","nameIdentifierScheme":"e-Rad_Researcher","nameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=20624323"}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"0000000106573887","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"https://isni.org/isni/0000000106573887"}],"affiliationNames":[{"affiliationName":"宮崎大学","affiliationNameLang":"ja"},{"affiliationName":"University of Miyazaki","affiliationNameLang":"en"}]}],"creatorNames":[{"creatorName":"奈須, 遵太","creatorNameLang":"ja"},{"creatorName":"ナス, ジュンタ","creatorNameLang":"ja-Kana"},{"creatorName":"Nasu, Junta","creatorNameLang":"en"}],"familyNames":[{"familyName":"奈須","familyNameLang":"ja"},{"familyName":"ナス","familyNameLang":"ja-Kana"},{"familyName":"Nasu","familyNameLang":"en"}],"givenNames":[{"givenName":"遵太","givenNameLang":"ja"},{"givenName":"ジュンタ","givenNameLang":"ja-Kana"},{"givenName":"Junta","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"34707","nameIdentifierScheme":"WEKO"}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"0000000106573887","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"https://isni.org/isni/0000000106573887"}],"affiliationNames":[{"affiliationName":"宮崎大学","affiliationNameLang":"ja"},{"affiliationName":"University of Miyazaki","affiliationNameLang":"en"}]}],"creatorNames":[{"creatorName":"福井, 丈仁","creatorNameLang":"ja"},{"creatorName":"フクイ, タケヒト","creatorNameLang":"ja-Kana"},{"creatorName":"Fukui, Takehito","creatorNameLang":"en"}],"familyNames":[{"familyName":"福井","familyNameLang":"ja"},{"familyName":"フクイ","familyNameLang":"ja-Kana"},{"familyName":"Fukui","familyNameLang":"en"}],"givenNames":[{"givenName":"丈仁","givenNameLang":"ja"},{"givenName":"タケヒト","givenNameLang":"ja-Kana"},{"givenName":"Takehito","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"34349","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"80942094","nameIdentifierScheme":"e-Rad_Researcher","nameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=80942094"}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"0000000106573887","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"https://isni.org/isni/0000000106573887"}],"affiliationNames":[{"affiliationName":"宮崎大学","affiliationNameLang":"ja"},{"affiliationName":"University of Miyazaki","affiliationNameLang":"en"}]}],"creatorNames":[{"creatorName":"西川, 陽太郎","creatorNameLang":"ja"},{"creatorName":"ニシカワ, ヨウタロウ","creatorNameLang":"ja-Kana"},{"creatorName":"Nishikawa, Yotaro","creatorNameLang":"en"}],"familyNames":[{"familyName":"西川","familyNameLang":"ja"},{"familyName":"ニシカワ","familyNameLang":"ja-Kana"},{"familyName":"Nishikawa","familyNameLang":"en"}],"givenNames":[{"givenName":"陽太郎","givenNameLang":"ja"},{"givenName":"ヨウタロウ","givenNameLang":"ja-Kana"},{"givenName":"Yotaro","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"34572","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"30827374","nameIdentifierScheme":"e-Rad_Researcher","nameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=30827374"}]},{"creatorNames":[{"creatorName":"Sparwasser, Tim","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Choijookhuu, Narantsog","creatorNameLang":"en"},{"creatorName":"チヨウジヨウフ, ナランツオツク","creatorNameLang":"ja"},{"creatorName":"チヨウジヨウフ, ナランツオツク","creatorNameLang":"ja-Kana"}],"familyNames":[{"familyName":"Choijookhuu","familyNameLang":"en"},{"familyName":"チヨウジヨウフ","familyNameLang":"ja"},{"familyName":"チヨウジヨウフ","familyNameLang":"ja-Kana"}],"givenNames":[{"givenName":"Narantsog","givenNameLang":"en"},{"givenName":"ナランツオツク","givenNameLang":"ja"},{"givenName":"ナランツオツク","givenNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"26967","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"90640962","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=90640962"}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"0000000106573887","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"https://isni.org/isni/0000000106573887"}],"affiliationNames":[{"affiliationName":"宮崎大学","affiliationNameLang":"ja"},{"affiliationName":"University of Miyazaki","affiliationNameLang":"en"}]}],"creatorNames":[{"creatorName":"菱川, 善隆","creatorNameLang":"ja"},{"creatorName":"ヒシカワ, ヨシタカ","creatorNameLang":"ja-Kana"},{"creatorName":"Hishikawa, Yoshitaka","creatorNameLang":"en"}],"familyNames":[{"familyName":"菱川","familyNameLang":"ja"},{"familyName":"ヒシカワ","familyNameLang":"ja-Kana"},{"familyName":"Hishikawa","familyNameLang":"en"}],"givenNames":[{"givenName":"善隆","givenNameLang":"ja"},{"givenName":"ヨシタカ","givenNameLang":"ja-Kana"},{"givenName":"Yoshitaka","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"34189","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"60304276","nameIdentifierScheme":"e-Rad_Researcher","nameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=60304276"}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"0000000106573887","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"https://isni.org/isni/0000000106573887"}],"affiliationNames":[{"affiliationName":"宮崎大学","affiliationNameLang":"ja"},{"affiliationName":"University of Miyazaki","affiliationNameLang":"en"}]}],"creatorNames":[{"creatorName":"中村, 雄","creatorNameLang":"ja"},{"creatorName":"ナカムラ, タケシ","creatorNameLang":"ja-Kana"},{"creatorName":"Nakamura, ","creatorNameLang":"en"}],"familyNames":[{"familyName":"中村","familyNameLang":"ja"},{"familyName":"ナカムラ","familyNameLang":"ja-Kana"},{"familyName":"Nakamura","familyNameLang":"en"}],"givenNames":[{"givenName":"雄","givenNameLang":"ja"},{"givenName":"タケシ","givenNameLang":"ja-Kana"},{"givenName":"","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"30180","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"50750931","nameIdentifierScheme":"e-Rad_Researcher","nameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=50750931"}]},{"creatorNames":[{"creatorName":"Tono, Tetsuya","creatorNameLang":"en"},{"creatorName":"東野, 哲也","creatorNameLang":"ja"},{"creatorName":"トウノ, テツヤ","creatorNameLang":"ja-Kana"}],"familyNames":[{"familyName":"Tono","familyNameLang":"en"},{"familyName":"東野","familyNameLang":"ja"},{"familyName":"トウノ","familyNameLang":"ja-Kana"}],"givenNames":[{"givenName":"Tetsuya","givenNameLang":"en"},{"givenName":"哲也","givenNameLang":"ja"},{"givenName":"テツヤ","givenNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"9835","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"80145424","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=80145424"}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"0000000106573887","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"https://isni.org/isni/0000000106573887"}],"affiliationNames":[{"affiliationName":"宮崎大学","affiliationNameLang":"ja"},{"affiliationName":"University of Miyazaki","affiliationNameLang":"en"}]}],"creatorNames":[{"creatorName":"佐藤, 克明","creatorNameLang":"ja"},{"creatorName":"サトウ, カツアキ","creatorNameLang":"ja-Kana"},{"creatorName":"Sato, Katsuaki","creatorNameLang":"en"}],"familyNames":[{"familyName":"佐藤","familyNameLang":"ja"},{"familyName":"サトウ","familyNameLang":"ja-Kana"},{"familyName":"Sato","familyNameLang":"en"}],"givenNames":[{"givenName":"克明","givenNameLang":"ja"},{"givenName":"カツアキ","givenNameLang":"ja-Kana"},{"givenName":"Katsuaki","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"30111","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"40301147","nameIdentifierScheme":"e-Rad_Researcher","nameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=40301147"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2023-10-30"}],"filename":"s42003-020-01466-3.pdf","filesize":[{"value":"3.3 MB"}],"format":"application/pdf","licensetype":"license_0","mimetype":"application/pdf","url":{"label":"本文","objectType":"fulltext","url":"https://miyazaki-u.repo.nii.ac.jp/record/2000185/files/s42003-020-01466-3.pdf"},"version_id":"001969f6-9ffa-4dc5-91af-fdac3feff258"},{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2023-10-30"}],"filename":"42003_2020_1466_MOESM1_ESM.pdf","filesize":[{"value":"4 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"Supplementary Information","objectType":"other","url":"https://miyazaki-u.repo.nii.ac.jp/record/2000185/files/42003_2020_1466_MOESM1_ESM.pdf"},"version_id":"2b7d621f-4250-4e87-9d0d-03442cd4d394"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Essential role of submandibular lymph node dendritic cells in protective sublingual immunotherapy against murine allergy","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Essential role of submandibular lymph node dendritic cells in protective sublingual immunotherapy against murine allergy","subitem_title_language":"en"}]},"item_type_id":"10001","owner":"9","path":["76","64"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2023-10-30"},"publish_date":"2023-10-30","publish_status":"0","recid":"2000185","relation_version_is_last":true,"title":["Essential role of submandibular lymph node dendritic cells in protective sublingual immunotherapy against murine allergy"],"weko_creator_id":"9","weko_shared_id":-1},"updated":"2025-01-17T05:21:11.867525+00:00"}