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健康成人男性におけるイミダフェナシン錠0.1mg粉砕単回経口投与時の薬物動態の検討
http://hdl.handle.net/10458/3857
http://hdl.handle.net/10458/385729c712fe-d9ea-4f14-a26b-97df3ab87941
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2012-07-25 | |||||
| タイトル | ||||||
| タイトル | 健康成人男性におけるイミダフェナシン錠0.1mg粉砕単回経口投与時の薬物動態の検討 | |||||
| 言語 | ja | |||||
| 言語 | ||||||
| 言語 | jpn | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| キーワード | Imidafenacin, Crushing tablets, Pharmacokinetics, Safety | |||||
| 資源タイプ | ||||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| その他（別言語等）のタイトル | ||||||
| その他のタイトル | ケンコウ セイジン ダンセイ ニオケル イミダフェナシンジョウ レイテンイチミリグラム フンサイ タンカイケイコウトウヨ ジ ノ ヤクブツ ドウタイ ノ ケントウ | |||||
| 言語 | ja-Kana | |||||
| 著者 |
井上, 勝己
× 井上, 勝己× 下村, 貴宏× 賀本, 敏行 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | The crushing of tablets and opening of capsules should not be performed without proper care, as these actions may adversely affect the pharmaceutical release mechanisms. However, various clinical circumstances occasionally necessitate these actions. The long-term stability of the commercial formulation of imidafenacin was confirmed after crushing of tablets. For the safe administration of crushed imidafenacin tablets, we examined the pharmacokinetics of crushed imidafenacin 0. 1-mg tablet after single oral administration in healthy men. Plasma concentrations were measured in 6 male volunteers （age, 33.3± 10.6 years） orally administered crushed imidafenacin under fasting conditions. Imidafenacin was rapidly absorbed and plasma concentrations peaked （Cmax） at 414±108 pg/ml after 1.5 h （Tmax ; median）, after which the drug was rapidly eliminated with a half-life （t1/2） of 2.8±0. 3 h. Area under the plasma concentration-time curve （AUC0-10） was 1,680±334 pg･h/ml. There were no significant differences in Cmax, Tmax and t1/2 between the crushed and tablet medications. Thus, crushing has almost no influence on the pharmacokinetics of imidafenacin. Consequently, this study was made available as information for patients requiring crushed anticholinergic agents. | |||||
| 言語 | en | |||||
| 書誌情報 |
ja : 泌尿器科紀要 巻 57, 号 12, p. 677-681, 発行日 2011-12 |
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| 出版者 | ||||||
| 出版者 | 泌尿器科紀要刊行会 | |||||
| 言語 | ja | |||||
