{"created":"2023-05-15T09:57:46.881894+00:00","id":1623,"links":{},"metadata":{"_buckets":{"deposit":"ef343d15-5a9f-453c-a22f-bf761279c6be"},"_deposit":{"created_by":5,"id":"1623","owners":[5],"pid":{"revision_id":0,"type":"depid","value":"1623"},"status":"published"},"_oai":{"id":"oai:miyazaki-u.repo.nii.ac.jp:00001623","sets":["72","72:30"]},"author_link":["9639","9783","9782"],"control_number":"1623","item_10001_alternative_title_1":{"attribute_name":"その他（別言語等）のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"ケンコウ セイジン ダンセイ ニオケル イミダフェナシンジョウ レイテンイチミリグラム フンサイ タンカイケイコウトウヨ ジ ノ ヤクブツ ドウタイ ノ ケントウ","subitem_alternative_title_language":"ja-Kana"}]},"item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2011-12","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"12","bibliographicPageEnd":"681","bibliographicPageStart":"677","bibliographicVolumeNumber":"57","bibliographic_titles":[{"bibliographic_title":"泌尿器科紀要","bibliographic_titleLang":"ja"}]}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"The crushing of tablets and opening of capsules should not be performed without proper care, as these actions may adversely affect the pharmaceutical release mechanisms. However, various clinical circumstances occasionally necessitate these actions. The long-term stability of the commercial formulation of imidafenacin was confirmed after crushing of tablets. For the safe administration of crushed imidafenacin tablets, we examined the pharmacokinetics of crushed imidafenacin 0. 1-mg tablet after single oral administration in healthy men. Plasma concentrations were measured in 6 male volunteers （age, 33.3± 10.6 years） orally administered crushed imidafenacin under fasting conditions. Imidafenacin was rapidly absorbed and plasma concentrations peaked （Cmax） at 414±108 pg/ml after 1.5 h （Tmax ; median）, after which the drug was rapidly eliminated with a half-life （t1/2） of 2.8±0. 3 h. Area under the plasma concentration-time curve （AUC0-10） was 1,680±334 pg･h/ml. There were no significant differences in Cmax, Tmax and t1/2 between the crushed and tablet medications. Thus, crushing has almost no influence on the pharmacokinetics of imidafenacin. Consequently, this study was made available as information for patients requiring crushed anticholinergic agents.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"泌尿器科紀要刊行会","subitem_publisher_language":"ja"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"井上, 勝己","creatorNameLang":"ja"},{"creatorName":"イノウエ, カツミ","creatorNameLang":"ja-Kana"},{"creatorName":"Inoue, Katsumi","creatorNameLang":"en"}],"familyNames":[{"familyName":"井上","familyNameLang":"ja"},{"familyName":"イノウエ","familyNameLang":"ja-Kana"},{"familyName":"Inoue","familyNameLang":"en"}],"givenNames":[{"givenName":"勝己","givenNameLang":"ja"},{"givenName":"カツミ","givenNameLang":"ja-Kana"},{"givenName":"Katsumi","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"9639","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"下村, 貴宏","creatorNameLang":"ja"},{"creatorName":"シタムラ, タカヒロ","creatorNameLang":"ja-Kana"},{"creatorName":"Shitamura, Takahiro","creatorNameLang":"en"}],"familyNames":[{"familyName":"下村","familyNameLang":"ja"},{"familyName":"シタムラ","familyNameLang":"ja-Kana"},{"familyName":"Shitamura","familyNameLang":"en"}],"givenNames":[{"givenName":"貴宏","givenNameLang":"ja"},{"givenName":"タカヒロ","givenNameLang":"ja-Kana"},{"givenName":"Takahiro","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"9782","nameIdentifierScheme":"WEKO"}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"0000000106573887","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"https://isni.org/isni/0000000106573887"}],"affiliationNames":[{"affiliationName":"宮崎大学","affiliationNameLang":"ja"},{"affiliationName":"University of Miyazaki","affiliationNameLang":"en"}]}],"creatorNames":[{"creatorName":"賀本, 敏行","creatorNameLang":"ja"},{"creatorName":"カモト, トシユキ","creatorNameLang":"ja-Kana"},{"creatorName":"Kamoto, Toshiyuki","creatorNameLang":"en"}],"familyNames":[{"familyName":"賀本","familyNameLang":"ja"},{"familyName":"カモト","familyNameLang":"ja-Kana"},{"familyName":"Kamoto","familyNameLang":"en"}],"givenNames":[{"givenName":"敏行","givenNameLang":"ja"},{"givenName":"トシユキ","givenNameLang":"ja-Kana"},{"givenName":"Toshiyuki","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"9783","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"00281098","nameIdentifierScheme":"e-Rad_Researcher","nameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=00281098"}]}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Imidafenacin, Crushing tablets, Pharmacokinetics, Safety","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"健康成人男性におけるイミダフェナシン錠0.1mg粉砕単回経口投与時の薬物動態の検討","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"健康成人男性におけるイミダフェナシン錠0.1mg粉砕単回経口投与時の薬物動態の検討","subitem_title_language":"ja"}]},"item_type_id":"10001","owner":"5","path":["72","30"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2012-07-25"},"publish_date":"2012-07-25","publish_status":"0","recid":"1623","relation_version_is_last":true,"title":["健康成人男性におけるイミダフェナシン錠0.1mg粉砕単回経口投与時の薬物動態の検討"],"weko_creator_id":"5","weko_shared_id":-1},"updated":"2025-06-01T23:49:13.405708+00:00"}