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Induction of aquaporin 1 by dexamethasone in lipid rafts in immortalized brain microvascular endothelial cells
http://hdl.handle.net/10458/1510
http://hdl.handle.net/10458/15101353e32f-53a7-4a09-9354-9a34f66e68d5
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
Brain Res1123 1 2006.pdf (606.5 kB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||
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| 公開日 | 2008-04-09 | |||||
| タイトル | ||||||
| タイトル | Induction of aquaporin 1 by dexamethasone in lipid rafts in immortalized brain microvascular endothelial cells | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| キーワード | Aquaporin 1, Brain microvessels, Lipid rafts, Caveolin, Glucocorticoid, Edema | |||||
| 資源タイプ | ||||||
| 資源タイプ | journal article | |||||
| 著者 |
小林, 英幸
× 小林, 英幸× 横尾, 宏毅× 柳田, 俊彦× 佐藤, 伸矢× 和田, 明彦× 横尾, 宏毅× Satoh, Shinya× Kis, Bela× Deli, Maria× Niwa, Masami× Wada, Akihiko |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Water homeostasis in the brain is essential for brain function. We have studied how aquaporin （AQP） 1 expression in GP8 immortalized rat brain microvascular endothelial cells is regulated by glucocorticoid. AQP1 protein level was raised by dexamethasone treatment in a time- and concentration-dependent manner. The up-regulation of AQP1 protein by dexamethasone was associated with an increase of AQP1 mRNA level, with no change in the degradation rate of AQP1 mRNA. AQP1 was concentrated in detergent–insoluble fractions in the cells treated with or without dexamethasone, suggesting that function/trafficking of AQP1 may be regulated via the interaction with lipid rafts. Since glucocorticoid therapy has well known beneficial effects in the treatment of brain edema, the induction of AQP1 by dexamethasone raises a possibility that AQP1 plays a role in ameliorating brain edema. |
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| 言語 | en | |||||
| 書誌情報 |
en : Brain research : international multidisciplinary journal devoted to fundamental research in the brain sciences 巻 1123, 号 1, p. 12-19, 発行日 2006-12-06 |
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| 出版者 | ||||||
| 出版者 | Elsevier | |||||
| 言語 | en | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 00068993 | |||||
| 書誌レコードID | ||||||
| 収録物識別子タイプ | NCID | |||||
| 収録物識別子 | AA0057324X | |||||
| 関連サイト | ||||||
| 識別子タイプ | URI | |||||
| 関連識別子 | http://www.elsevier.com/wps/find/journaldescription.cws_home/622287/description | |||||
| 関連名称 | http://www.elsevier.com/wps/find/journaldescription.cws_home/622287/description | |||||
| 著者版フラグ | ||||||
| 出版タイプ | VoR | |||||
