@article{oai:miyazaki-u.repo.nii.ac.jp:00001616,
 author = {小林, 英幸 and Kobayashi, Hideyuki and 横尾, 宏毅 and Yokoo, Hiroki and 柳田, 俊彦 and Yanagita, Toshihiko and 佐藤, 伸矢 and 和田, 明彦 and 横尾, 宏毅 and Yokoo, Hiroki and Satoh, Shinya and Kis, Bela and Deli, Maria and Niwa, Masami and Wada, Akihiko},
 issue = {1},
 journal = {Brain research : international multidisciplinary journal devoted to fundamental research in the brain sciences},
 month = {Dec},
 note = {Water homeostasis in the brain is essential for brain function. We have studied how
aquaporin （AQP） 1 expression in GP8 immortalized rat brain microvascular endothelial
cells is regulated by glucocorticoid. AQP1 protein level was raised by dexamethasone
treatment in a time- and concentration-dependent manner. The up-regulation of AQP1
protein by dexamethasone was associated with an increase of AQP1 mRNA level, with
no change in the degradation rate of AQP1 mRNA. AQP1 was concentrated in
detergent–insoluble fractions in the cells treated with or without dexamethasone,
suggesting that function/trafficking of AQP1 may be regulated via the interaction with
lipid rafts. Since glucocorticoid therapy has well known beneficial effects in the
treatment of brain edema, the induction of AQP1 by dexamethasone raises a possibility
that AQP1 plays a role in ameliorating brain edema.},
 pages = {12--19},
 title = {Induction of aquaporin 1 by dexamethasone in lipid rafts in immortalized brain microvascular endothelial cells},
 volume = {1123},
 year = {2006},
 yomi = {コバヤシ, ヒデユキ and ヨコオ, ヒロキ and ヤナギタ, トシヒコ and サトウ, シンヤ and ワダ, アキヒコ and ヨコオ, ヒロキ}
}