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Tonsillectomy Delays Progression of Advanced IgA Nephropathy to End-Stage Kidney Disease
http://hdl.handle.net/10458/3712
http://hdl.handle.net/10458/3712da6e481e-42ef-4da3-b288-26d5443e7c67
| 名前 / ファイル | ライセンス | アクション |
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1470kamatsu.pdf (1.1 MB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||
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| 公開日 | 2012-05-30 | |||||
| タイトル | ||||||
| タイトル | Tonsillectomy Delays Progression of Advanced IgA Nephropathy to End-Stage Kidney Disease | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| キーワード | lgA nephropathy, glomerulonephritis, tonsillectomy, renal outcome, end-stage kidney disease | |||||
| 資源タイプ | ||||||
| 資源タイプ | journal article | |||||
| 著者 |
小松, 弘幸
× 小松, 弘幸× 藤元, 昭一× 菊池, 正雄× 佐藤, 祐二× 北村, 和雄 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Aims: Several investigators have described the effect of tonsillectomy on unnary abnormalities and long-term renal survival rates in patients with IgA nephropathy （IgAN）, especially during the early-stage of the disease. However, whether tonsillectomy affects the rate of IgAN progress, even when the disease is in the advanced stage remains obscure. Methods: Forty-six of 365 patients who were histologically diagnosed with IgAN eventually reached end-stage kidney disease （ESKD） between 1981 and 2006. The periods from diagnosis to ESKD with renal-replacement therapy （RRT） were compared between patients with ESKD who had undergone tonsillectomy （n=15） as initial therapy for IgAN or not （n=31）. Relationships among risk factors, initial treatment and rates of progression to ESKD were also examined using multivariate analysis in a retrospective cohort study of the 46 patients. Results: The duration between renal biopsy and initiation of RRT was significantly extended for patients with, than without tonsillectomy （9.8 ± 6.0 vs. 5.8 ± 4.0 years, p=0.007; unpaired t-test）. The RRT-free survival advantage in patients with tonsillectomy was also evident in Kaplan-Meier curves （p=0.007 by log-rank test）. Logistic regression analysis showed that a high serum creatinine value at biopsy and severe histological damage were risk factors affecting rapid progression （within 7 years from diagnosis） to ESKD, whereas tonsillectomy apparently delayed disease progression （odds ratio, 0.09; '95% CI, 0.01-0.75; p=0.026）. Conclusion:Tonsillectomy might delay the rate of progression even when IgAN is relatively advanced, although the present study could not confirm whether it prevents progression to ESKD. | |||||
| 言語 | en | |||||
| 書誌情報 |
en : Renal Failure 巻 34, 号 4, p. 449-454, 発行日 2012-05 |
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| 出版者 | ||||||
| 出版者 | Informa Healthcare | |||||
| 言語 | en | |||||
| PubMed番号 | ||||||
| 関連タイプ | isVersionOf | |||||
| 識別子タイプ | PMID | |||||
| 関連識別子 | 22260382 | |||||
| DOI | ||||||
| 関連タイプ | isVersionOf | |||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | https://doi.org/10.3109/0886022x.2011.653775 | |||||
| 権利 | ||||||
| 言語 | en | |||||
| 権利情報 | © 2012 Informa Plc | |||||
| 著者版フラグ | ||||||
| 出版タイプ | AM | |||||
