{"created":"2023-05-15T09:57:45.063675+00:00","id":1593,"links":{},"metadata":{"_buckets":{"deposit":"a3912f2d-5887-47a8-a062-9d9accfc9a35"},"_deposit":{"created_by":5,"id":"1593","owner":"5","owners":[5],"pid":{"revision_id":0,"type":"depid","value":"1593"},"status":"published"},"_oai":{"id":"oai:miyazaki-u.repo.nii.ac.jp:00001593","sets":["72","72:30"]},"author_link":["7929","7768","8158","8155","8142"],"item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2012-05","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"4","bibliographicPageEnd":"454","bibliographicPageStart":"449","bibliographicVolumeNumber":"34","bibliographic_titles":[{"bibliographic_title":"Renal Failure","bibliographic_titleLang":"en"}]}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Aims: Several investigators have described the effect of tonsillectomy on unnary abnormalities and long-term renal survival rates in patients with IgA nephropathy （IgAN）, especially during the early-stage of the disease. However, whether tonsillectomy affects the rate of IgAN progress, even when the disease is in the advanced stage remains obscure. Methods: Forty-six of 365 patients who were histologically diagnosed with IgAN eventually reached end-stage kidney disease （ESKD） between 1981 and 2006. The periods from diagnosis to ESKD with renal-replacement therapy （RRT） were compared between patients with ESKD who had undergone tonsillectomy （n=15） as initial therapy for IgAN or not （n=31）. Relationships among risk factors, initial treatment and rates of progression to ESKD were also examined using multivariate analysis in a retrospective cohort study of the 46 patients. Results: The duration between renal biopsy and initiation of RRT was significantly extended for patients with, than without tonsillectomy （9.8 ± 6.0 vs. 5.8 ± 4.0 years, p=0.007; unpaired t-test）. The RRT-free survival advantage in patients with tonsillectomy was also evident in Kaplan-Meier curves （p=0.007 by log-rank test）. Logistic regression analysis showed that a high serum creatinine value at biopsy and severe histological damage were risk factors affecting rapid progression （within 7 years from diagnosis） to ESKD, whereas tonsillectomy apparently delayed disease progression （odds ratio, 0.09; '95% CI, 0.01-0.75; p=0.026）. Conclusion:Tonsillectomy might delay the rate of progression even when IgAN is relatively advanced, although the present study could not confirm whether it prevents progression to ESKD.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Informa Healthcare","subitem_publisher_language":"en"}]},"item_10001_relation_13":{"attribute_name":"PubMed番号","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"22260382","subitem_relation_type_select":"PMID"}}]},"item_10001_relation_14":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.3109/0886022x.2011.653775","subitem_relation_type_select":"DOI"}}]},"item_10001_rights_15":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"© 2012 Informa Plc","subitem_rights_language":"en"}]},"item_10001_version_type_20":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"0000000106573887","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"https://isni.org/isni/0000000106573887"}],"affiliationNames":[{"affiliationName":"宮崎大学","affiliationNameLang":"ja"},{"affiliationName":"University of Miyazaki","affiliationNameLang":"en"}]}],"creatorNames":[{"creatorName":"小松, 弘幸","creatorNameLang":"ja"},{"creatorName":"コマツ, ヒロユキ","creatorNameLang":"ja-Kana"},{"creatorName":"Komatsu, 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シヨウイチ","creatorNameLang":"ja-Kana"},{"creatorName":"Fujimoto, Shouichi","creatorNameLang":"en"}],"familyNames":[{"familyName":"藤元","familyNameLang":"ja"},{"familyName":"フジモト","familyNameLang":"ja-Kana"},{"familyName":"Fujimoto","familyNameLang":"en"}],"givenNames":[{"givenName":"昭一","givenNameLang":"ja"},{"givenName":"シヨウイチ","givenNameLang":"ja-Kana"},{"givenName":"Shouichi","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"8142","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"80173467","nameIdentifierScheme":"e-Rad_Researcher","nameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=80173467"}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"0000000106573887","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"https://isni.org/isni/0000000106573887"}],"affiliationNames":[{"affiliationName":"宮崎大学","affiliationNameLang":"ja"},{"affiliationName":"University of 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Nephropathy to End-Stage Kidney Disease","subitem_title_language":"en"}]},"item_type_id":"10001","owner":"5","path":["72","30"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2012-05-30"},"publish_date":"2012-05-30","publish_status":"0","recid":"1593","relation_version_is_last":true,"title":["Tonsillectomy Delays Progression of Advanced IgA Nephropathy to End-Stage Kidney Disease"],"weko_creator_id":"5","weko_shared_id":2},"updated":"2025-01-07T04:54:54.416694+00:00"}