WEKO3
アイテム
Chronic thrombopoietin overexpression induces mesangioproliferative glomerulopathy in mice
http://hdl.handle.net/10458/1059
http://hdl.handle.net/10458/1059b26d3112-878b-424a-a1ac-cd96087f2b60
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
Shimoda.pdf (214.6 kB)
|
|
| Item type | 学術雑誌論文 / Journal Article(1) | |||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 公開日 | 2007-12-21 | |||||||||||||||||
| タイトル | ||||||||||||||||||
| タイトル | Chronic thrombopoietin overexpression induces mesangioproliferative glomerulopathy in mice | |||||||||||||||||
| 言語 | en | |||||||||||||||||
| 言語 | ||||||||||||||||||
| 言語 | eng | |||||||||||||||||
| キーワード | ||||||||||||||||||
| 言語 | en | |||||||||||||||||
| 主題Scheme | Other | |||||||||||||||||
| 主題 | thrombopoietin, mesangial cell, mesangial matrix, TGF-β1, PDGF-BB, glomerulopathy | |||||||||||||||||
| 資源タイプ | ||||||||||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||||||||||
| 資源タイプ | journal article | |||||||||||||||||
| その他（別言語等）のタイトル | ||||||||||||||||||
| その他のタイトル | Glomerulopathy in TPO Transgenic Mice | |||||||||||||||||
| 言語 | en | |||||||||||||||||
| 著者 |
下田, 晴子
× 下田, 晴子
WEKO
7989
× Yamamoto, Masahiro× Shide, Kotaro× Kamezaki, Kenjirou× Matsuda, Tadashi× Ogawa, Katsuhiro× Harada, Mine× 下田, 和哉
WEKO
7997
|
|||||||||||||||||
| 抄録 | ||||||||||||||||||
| 内容記述タイプ | Abstract | |||||||||||||||||
| 内容記述 | We previously reported that mice transgenic （Tg） for thrombopoietin （TPO） developed progressive fibrosis and osteosclerosis of the bone marrow. Here, we show that TPO-overexpressing mice also exhibited notable histological changes in the kidneys, including an increased number of mesangial cells, expansion of the mesangial matrix in the glomerulus, and atrophy of the renal tubuli. Plasma transforming growth factor （TGF）-1 and platelet-derived growth factor （PDGF）-BB, which could induce mesangioproliferative responses in glomeruli, were both elevated in TPO Tg mice, even though TPO itself has no effect on mesangial cells due to their lack of c-Mpl. The mesangial proliferative change in TPO Tg mice was thought to be induced by the elevation of these cytokines. In conclusion, our finding that TPO-overexpressing mice developed mesangioproliferative glomerulopathy might represent an undesirable effect of chronically elevated TPO in vivo, which should be taken into consideration before new TPO-like growth factors become available in clinical practice. | |||||||||||||||||
| 言語 | en | |||||||||||||||||
| 内容記述 | ||||||||||||||||||
| 内容記述タイプ | Other | |||||||||||||||||
| 内容記述 | Copyright © 2007 Wiley-Liss, Inc. or copyright owner as specified in the Journal | |||||||||||||||||
| 言語 | en | |||||||||||||||||
| 書誌情報 |
en : American journal of hematology 巻 82, 号 9, p. 802-806, 発行日 2007-06-01 |
|||||||||||||||||
| 出版者 | ||||||||||||||||||
| 出版者 | John Wiley & Sons | |||||||||||||||||
| 言語 | en | |||||||||||||||||
| ISSN | ||||||||||||||||||
| 収録物識別子タイプ | ISSN | |||||||||||||||||
| 収録物識別子 | 03618609 | |||||||||||||||||
| 書誌レコードID | ||||||||||||||||||
| 収録物識別子タイプ | NCID | |||||||||||||||||
| 収録物識別子 | AA00520673 | |||||||||||||||||
| 著者版フラグ | ||||||||||||||||||
| 出版タイプ | AM | |||||||||||||||||
| 出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||||||||||||||
