{"created":"2023-05-15T09:57:41.106603+00:00","id":1520,"links":{},"metadata":{"_buckets":{"deposit":"19ac6b69-4dab-4b7e-9f75-cddc4800460f"},"_deposit":{"created_by":5,"id":"1520","owner":"5","owners":[5],"pid":{"revision_id":0,"type":"depid","value":"1520"},"status":"published"},"_oai":{"id":"oai:miyazaki-u.repo.nii.ac.jp:00001520","sets":["72","72:30"]},"author_link":["9000","7989","8999","9002","9003","9004","7997","9001"],"control_number":"1520","item_10001_alternative_title_1":{"attribute_name":"その他（別言語等）のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"Glomerulopathy in TPO Transgenic Mice","subitem_alternative_title_language":"en"}]},"item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2007-06-01","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"9","bibliographicPageEnd":"806","bibliographicPageStart":"802","bibliographicVolumeNumber":"82","bibliographic_titles":[{"bibliographic_title":"American journal of hematology","bibliographic_titleLang":"en"}]}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"We previously reported that mice transgenic （Tg） for thrombopoietin （TPO） developed progressive fibrosis and osteosclerosis of the bone marrow. Here, we show that TPO-overexpressing mice also exhibited notable histological changes in the kidneys, including an increased number of mesangial cells, expansion of the mesangial matrix in the glomerulus, and atrophy of the renal tubuli. Plasma transforming growth factor （TGF）-1 and platelet-derived growth factor （PDGF）-BB, which could induce mesangioproliferative responses in glomeruli, were both elevated in TPO Tg mice, even though TPO itself has no effect on mesangial cells due to their lack of c-Mpl. The mesangial proliferative change in TPO Tg mice was thought to be induced by the elevation of these cytokines. In conclusion, our finding that TPO-overexpressing mice developed mesangioproliferative glomerulopathy might represent an undesirable effect of chronically elevated TPO in vivo, which should be taken into consideration before new TPO-like growth factors become available in clinical practice.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10001_description_6":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"Copyright  © 2007  Wiley-Liss, Inc. or copyright owner as specified in the Journal","subitem_description_language":"en","subitem_description_type":"Other"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"John Wiley & Sons","subitem_publisher_language":"en"}]},"item_10001_source_id_11":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AA00520673","subitem_source_identifier_type":"NCID"}]},"item_10001_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"03618609","subitem_source_identifier_type":"ISSN"}]},"item_10001_version_type_20":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"0000000106573887","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"https://isni.org/isni/0000000106573887"}],"affiliationNames":[{"affiliationName":"宮崎大学","affiliationNameLang":"ja"},{"affiliationName":"University of Miyazaki","affiliationNameLang":"en"}]}],"creatorNames":[{"creatorName":"下田, 晴子","creatorNameLang":"ja"},{"creatorName":"シモダ, ハルコ","creatorNameLang":"ja-Kana"},{"creatorName":"Shimoda, Haruko","creatorNameLang":"en"}],"familyNames":[{"familyName":"下田","familyNameLang":"ja"},{"familyName":"シモダ","familyNameLang":"ja-Kana"},{"familyName":"Shimoda","familyNameLang":"en"}],"givenNames":[{"givenName":"晴子","givenNameLang":"ja"},{"givenName":"ハルコ","givenNameLang":"ja-Kana"},{"givenName":"Haruko","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"7989","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Yamamoto, Masahiro","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"8999","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Shide, Kotaro","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"9000","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kamezaki, Kenjirou","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"9001","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Matsuda, Tadashi","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"9002","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ogawa, Katsuhiro","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"9003","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Harada, Mine","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"9004","nameIdentifierScheme":"WEKO"}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"0000000106573887","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"https://isni.org/isni/0000000106573887"}],"affiliationNames":[{"affiliationName":"宮崎大学","affiliationNameLang":"ja"},{"affiliationName":"University of Miyazaki","affiliationNameLang":"en"}]}],"creatorNames":[{"creatorName":"Shimoda, Kazuya","creatorNameLang":"en"},{"creatorName":"下田, 和哉","creatorNameLang":"ja"},{"creatorName":"シモダ, カズヤ","creatorNameLang":"ja-Kana"},{"creatorName":"Shimoda, 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glomerulopathy in mice","subitem_title_language":"en"}]},"item_type_id":"10001","owner":"5","path":["72","30"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2007-12-21"},"publish_date":"2007-12-21","publish_status":"0","recid":"1520","relation_version_is_last":true,"title":["Chronic thrombopoietin overexpression induces mesangioproliferative glomerulopathy in mice"],"weko_creator_id":"5","weko_shared_id":-1},"updated":"2025-01-07T04:29:55.613340+00:00"}