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Sequential changes in extracellular gamma-aminobutyric acid concentration during the development of amygdaloid kindling
http://hdl.handle.net/10458/2156
http://hdl.handle.net/10458/215606586857-f509-4cc1-9cf3-45614932d5fe
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
1-4a.pdf (383.3 kB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||
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| 公開日 | 2009-08-04 | |||||
| タイトル | ||||||
| タイトル | Sequential changes in extracellular gamma-aminobutyric acid concentration during the development of amygdaloid kindling | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| キーワード | Kindling, γ-aminobutyric acid(GABA), GABA receptors, Microdialysis, Hippocampus | |||||
| 資源タイプ | ||||||
| 資源タイプ | journal article | |||||
| 著者 |
Ueda, Yuto
× Ueda, Yuto× Tsuru, Noriko |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | To elucidate its role in seizure propagation during a kindling protocol, we monitored seizure-related changes in extracellular hippocampal gamma-aminobutyric acid （GABA） concentrations in brain dialysates at two times during the development of amygdaloid kindling. Brain dialysates were collected over 5 min periods from 10 min before to 90 min after stimuli at stage 3 （C-3）, and on the fifth consecutive day of stage 5 （5*C-5）. During each survey, extracellular GABA concentrations increased gradually to be plateau at 15-20 min that lasted for several hours after stimulus. GABA increase were about 50% over baseline at the partially kindled stage, and 150% at the fully kindled stage. These changes of extracellular hippocampal GABA space were similar in both hemispheres. Amygdaloid kindling is thus accompanied by a repetitive and progressive stimulusinduced increase in extracellular GABA levels in the ventral hippocampi lasts for several hours after stimulation. | |||||
| 言語 | en | |||||
| 書誌情報 |
en : Neurosciences 巻 20, p. 23-27, 発行日 1994 |
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| 出版者 | ||||||
| 出版者 | 日本脳科学会 | |||||
| 言語 | ja | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 03887448 | |||||
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| 収録物識別子タイプ | NCID | |||||
| 収録物識別子 | AN10033568 | |||||
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| 出版タイプ | VoR | |||||
