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Relationship between Serum IgA/C3 Ratio and Progression of IgA Nephropathy
http://hdl.handle.net/10458/2065
http://hdl.handle.net/10458/2065b5982492-7ba7-42f7-bf03-44b412fb6f38
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
2065-komatsu.pdf (753.8 kB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||
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| 公開日 | 2009-07-08 | |||||
| タイトル | ||||||
| タイトル | Relationship between Serum IgA/C3 Ratio and Progression of IgA Nephropathy | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| キーワード | IgA nephropathy, serum IgA/C3 ratio, serum IgA, complement, hematuria | |||||
| 資源タイプ | ||||||
| 資源タイプ | journal article | |||||
| 著者 |
小松, 弘幸
× 小松, 弘幸× 藤元, 昭一× Hara, Seiichiro× Sato, Yuji× Yamada, Kazuhiro× Eto, Tanenao |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Objective : The serum IgA/C3 ratio might be considered to serve as a diagnostic marker for patients with IgA nephropathy （IgAN）, but its value as a marker of the severity of histological lesions or prognosis is unknown. Methods : We studied the serum IgA/C3 ratio, using standardized reference material, in 86 patients with IgAN and in 32 with non-IgAN. The patients with IgAN were divided according to the severity of histological lesions （mild IgAN, n=29 and severe IgAN, n=57） based on Japanese clinical guidelines. Results : The serum IgA level was significantly higher, while its C3 level was lower in patients with severe IgAN compared to those with non-IgAN. However, these levels were not different between patients with mild IgAN and non-IgAN. In contrast, the serum IgA/C3 ratio obviously differed among the three groups （2.47±0.96 vs. 3.63±1.44 vs. 4.72±1.86; p<0.01, ANOVA）. Kaplan-Meier analysis of the patients with IgAN classified according to the mean serum IgA/C3 ratio revealed that the group with high serum IgA/C3 （4.5 and above） had a significantly poorer renal outcome （p<0.05, log-rank test）, since the cumulative renal survival rate at 5 years was 84.4% vs. 100%. The ratio （%） of patients with severe IgAN in whom hematuria disappeared, was significantly higher in the low, than in the high serum IgA/C3 group （41.9% vs. 15.4%; p<0.05, t-test）. Conclusion : The serum IgA/C3 ratio appears to reflect the histological severity of IgAN and could serve as a marker of the progression of IgAN. |
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| 言語 | en | |||||
| 書誌情報 |
en : Internal medicine 巻 43, 号 11, p. 1023-1028, 発行日 2004-11 |
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| 出版者 | ||||||
| 出版者 | Japanese Society of Internal Medicine | |||||
| 言語 | en | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 09182918 | |||||
| 書誌レコードID | ||||||
| 収録物識別子タイプ | NCID | |||||
| 収録物識別子 | AA10827774 | |||||
| PubMed番号 | ||||||
| 関連タイプ | isIdenticalTo | |||||
| 識別子タイプ | PMID | |||||
| 関連識別子 | 15609695 | |||||
| DOI | ||||||
| 関連タイプ | isIdenticalTo | |||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | https://doi.org/10.2169/internalmedicine.43.1023 | |||||
| 著者版フラグ | ||||||
| 出版タイプ | VoR | |||||
