{"created":"2023-05-15T10:53:46.646285+00:00","links":{},"metadata":{"_buckets":{"deposit":"8ecadacb-9d15-4fd4-bc1d-8b1f050b4274"},"_deposit":{"id":"1370.1","owners":[2],"pid":{"revision_id":0,"type":"depid","value":"1370.1"},"status":"published"},"_oai":{"id":"oai:miyazaki-u.repo.nii.ac.jp:00001370.1","sets":["72:30"]},"author_link":["7768","8142","8139","8158","8140","8160"],"item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2004-11","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"11","bibliographicPageEnd":"1028","bibliographicPageStart":"1023","bibliographicVolumeNumber":"43","bibliographic_titles":[{"bibliographic_title":"Internal medicine","bibliographic_titleLang":"en"}]}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Objective : The serum IgA/C3 ratio might be considered to serve as a diagnostic marker for patients with IgA nephropathy （IgAN）, but its value as a marker of the severity of histological lesions or prognosis is unknown. \nMethods : We studied the serum IgA/C3 ratio, using standardized reference material, in 86 patients with IgAN and in 32 with non-IgAN. The patients with IgAN were divided according to the severity of histological lesions （mild IgAN, n=29 and severe IgAN, n=57） based on Japanese clinical guidelines. \nResults : The serum IgA level was significantly higher, while its C3 level was lower in patients with severe IgAN compared to those with non-IgAN. However, these levels were not different between patients with mild IgAN and non-IgAN. In contrast, the serum IgA/C3 ratio obviously differed among the three groups （2.47±0.96 vs. 3.63±1.44 vs. 4.72±1.86; p<0.01, ANOVA）. Kaplan-Meier analysis of the patients with IgAN classified according to the mean serum IgA/C3 ratio revealed that the group with high serum IgA/C3 （4.5 and above） had a significantly poorer renal outcome （p<0.05, log-rank test）, since the cumulative renal survival rate at 5 years was 84.4% vs. 100%. The ratio （%） of patients with severe IgAN in whom hematuria disappeared, was significantly higher in the low, than in the high serum IgA/C3 group （41.9% vs. 15.4%; p<0.05, t-test）. \nConclusion : The serum IgA/C3 ratio appears to reflect the histological severity of IgAN and could serve as a marker of the progression of IgAN.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Japanese Society of Internal Medicine","subitem_publisher_language":"en"}]},"item_10001_relation_13":{"attribute_name":"PubMed番号","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"15609695","subitem_relation_type_select":"PMID"}}]},"item_10001_relation_14":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.2169/internalmedicine.43.1023","subitem_relation_type_select":"DOI"}}]},"item_10001_source_id_11":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AA10827774","subitem_source_identifier_type":"NCID"}]},"item_10001_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"09182918","subitem_source_identifier_type":"ISSN"}]},"item_10001_version_type_20":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"小松, 弘幸","creatorNameLang":"ja"},{"creatorName":"コマツ, ヒロユキ","creatorNameLang":"ja-Kana"},{"creatorName":"Komatsu, Hiroyuki","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"7768","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"30598339","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=30598339"}]},{"creatorNames":[{"creatorName":"藤元, 昭一","creatorNameLang":"ja"},{"creatorName":"フジモト, シヨウイチ","creatorNameLang":"ja-Kana"},{"creatorName":"Fujimoto, Shouichi","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"8142","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"80173467","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=80173467"}]},{"creatorNames":[{"creatorName":"Hara, Seiichiro","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"8139","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Sato, Yuji","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"8158","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Yamada, Kazuhiro","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"8140","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Eto, Tanenao","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"8160","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-06-21"}],"displaytype":"detail","filename":"2065-komatsu.pdf","filesize":[{"value":"753.8 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"2065-komatsu.pdf","url":"https://miyazaki-u.repo.nii.ac.jp/record/1370.1/files/2065-komatsu.pdf"},"version_id":"219c3aa9-dcca-4514-b4fe-e6b3847107de"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"IgA nephropathy, serum IgA/C3 ratio, serum IgA, complement, hematuria","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Relationship between Serum IgA/C3 Ratio and Progression of IgA Nephropathy","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Relationship between Serum IgA/C3 Ratio and Progression of IgA Nephropathy","subitem_title_language":"en"}]},"item_type_id":"10001","owner":"2","path":["30"],"pubdate":{"attribute_name":"公開日","attribute_value":"2009-07-08"},"publish_date":"2009-07-08","publish_status":"0","recid":"1370.1","relation_version_is_last":true,"title":["Relationship between Serum IgA/C3 Ratio and Progression of IgA Nephropathy"],"weko_creator_id":"2","weko_shared_id":2},"updated":"2024-05-27T04:06:43.204281+00:00"}