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ニガウリ種子由来粗精製レクチンの免疫アジュバント効果(臨床病理学)
http://hdl.handle.net/10458/2882
http://hdl.handle.net/10458/2882d7a0e943-3388-4a3b-a60c-c574b2ff1d84
名前 / ファイル | ライセンス | アクション |
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2882haga.pdf (306.4 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2010-05-26 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | Immunoadjuvant activity of crude lectin extracted from Momordica charantia seed | |||||
タイトル | ||||||
言語 | ja | |||||
タイトル | ニガウリ種子由来粗精製レクチンの免疫アジュバント効果(臨床病理学) | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
キーワード | lectin, Momordica charantia, vaccine adjuvant | |||||
資源タイプ | ||||||
資源タイプ | journal article | |||||
著者 |
黄, 莉
× 黄, 莉× 池尻, 藍× 清水, 佑也× 足立, 匠× 後藤, 義孝× 外山, 潤× 田中, 秀典× 明石, 良× 内田, 和幸× 宮田, 博規× 芳賀, 猛× Huang, Li× Ikejiri, Ai× Shimizu, Yuya× Adachi, Takumi× Toyama, Jun× Miyata, Hironori |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | The aim of this study is to investigate the immunoadjuvant activity of the crude Momordica charantia lectin (crMCL) extracted from seed using β-galactosidase (β-gal) as the model antigen. BALB/c mice were injected intramuscularly with β-gal alone or β-gal + crMCL for up to four immunizations at two-week intervals. After administration of 2 doses, the IgG-specific titer to β-gal was significantly higher in mice in the β-gal + crMCL group than in that from the animals from the β-gal alone group, while it was about the same in both groups after 1 dose. Our data suggest that crMCL may help raise antibodies under the prime and boost administration regimen and could be a potent vaccine adjuvant. | |||||
言語 | en | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | ニガウリ種子由来粗精製レクチン(CrMCL)のアジュバント効果について,ベータガラクトシダーゼをモデル抗原として解析した.BALB/cマウスを抗原単独投与群と抗原+CrMCL投与群に分け,血清中の抗原特異的IgG抗体価を測定したところ,1回免疫では両群で差がなかったが,追加免疫で抗原+crMCL投与群が有意に高かった. CrMCLはプライムブースト投与法に有用なアジュバントであることが示唆された. | |||||
言語 | ja | |||||
書誌情報 |
en : The journal of veterinary medical science en : Journal of veterinary medical science 巻 70, 号 5, p. 533-535, 発行日 2008-05-25 |
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出版者 | ||||||
言語 | en | |||||
出版者 | Japanese Society of Veterinary Science | |||||
出版者 | ||||||
言語 | ja | |||||
出版者 | 日本獣医学会 | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 09167250 | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 13477439 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA10796138 | |||||
PubMed番号 | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | PMID | |||||
関連識別子 | 18525182 | |||||
著者版フラグ | ||||||
出版タイプ | VoR |