{"created":"2023-05-15T09:57:00.932627+00:00","id":772,"links":{},"metadata":{"_buckets":{"deposit":"84aeda67-d04f-4912-8d15-7cc7fb4ab914"},"_deposit":{"created_by":5,"id":"772","owner":"5","owners":[5],"pid":{"revision_id":0,"type":"depid","value":"772"},"status":"published"},"_oai":{"id":"oai:miyazaki-u.repo.nii.ac.jp:00000772","sets":["74","74:26"]},"author_link":["4734","4735","4736","4737","2693","4739","4740","1585","939","4743","2692","4745","4746","4614","4748","4750","4754"],"item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2008-05-25","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"5","bibliographicPageEnd":"535","bibliographicPageStart":"533","bibliographicVolumeNumber":"70","bibliographic_titles":[{"bibliographic_title":"The journal of veterinary medical science","bibliographic_titleLang":"en"},{"bibliographic_title":"Journal of veterinary medical science","bibliographic_titleLang":"en"}]}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"The aim of this study is to investigate the immunoadjuvant activity of the crude Momordica charantia lectin （crMCL） extracted from seed using β-galactosidase （β-gal） as the model antigen. BALB/c mice were injected intramuscularly with β-gal alone or β-gal + crMCL for up to four immunizations at two-week intervals. After administration of 2 doses, the IgG-specific titer to β-gal was significantly higher in mice in the β-gal + crMCL group than in that from the animals from the β-gal alone group, while it was about the same in both groups after 1 dose. Our data suggest that crMCL may help raise antibodies under the prime and boost administration regimen and could be a potent vaccine adjuvant.","subitem_description_language":"en","subitem_description_type":"Abstract"},{"subitem_description":"ニガウリ種子由来粗精製レクチン（CrMCL）のアジュバント効果について,ベータガラクトシダーゼをモデル抗原として解析した.BALB/cマウスを抗原単独投与群と抗原+CrMCL投与群に分け,血清中の抗原特異的IgG抗体価を測定したところ,1回免疫では両群で差がなかったが,追加免疫で抗原+crMCL投与群が有意に高かった. CrMCLはプライムブースト投与法に有用なアジュバントであることが示唆された.","subitem_description_language":"ja","subitem_description_type":"Abstract"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Japanese Society of Veterinary Science","subitem_publisher_language":"en"},{"subitem_publisher":"日本獣医学会","subitem_publisher_language":"ja"}]},"item_10001_relation_13":{"attribute_name":"PubMed番号","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"18525182","subitem_relation_type_select":"PMID"}}]},"item_10001_source_id_11":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AA10796138","subitem_source_identifier_type":"NCID"}]},"item_10001_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"09167250","subitem_source_identifier_type":"ISSN"},{"subitem_source_identifier":"13477439","subitem_source_identifier_type":"ISSN"}]},"item_10001_version_type_20":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"黄, 莉","creatorNameLang":"ja"},{"creatorName":"ホー, リー","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"池尻, 藍","creatorNameLang":"ja"},{"creatorName":"イケジリ, アイ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"清水, 佑也","creatorNameLang":"ja"},{"creatorName":"シミズ, ユウヤ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"足立, 匠","creatorNameLang":"ja"},{"creatorName":"アダチ, タクミ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"後藤, 義孝","creatorNameLang":"ja"},{"creatorName":"ゴトウ, ヨシタカ","creatorNameLang":"ja-Kana"},{"creatorName":"Goto, Yoshitaka","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"外山, 潤","creatorNameLang":"ja"},{"creatorName":"トヤマ, ジュン","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"田中, 秀典","creatorNameLang":"ja"},{"creatorName":"タナカ, ヒデノリ","creatorNameLang":"ja-Kana"},{"creatorName":"Tanaka, Hidenori","creatorNameLang":"en"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"明石, 良","creatorNameLang":"ja"},{"creatorName":"アカシ, リョウ","creatorNameLang":"ja-Kana"},{"creatorName":"Akashi, Ryo","creatorNameLang":"en"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"内田, 和幸","creatorNameLang":"ja"},{"creatorName":"ウチダ, カズユキ","creatorNameLang":"ja-Kana"},{"creatorName":"Uchida, Kazuyuki","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"宮田, 博規","creatorNameLang":"ja"},{"creatorName":"ミヤタ, ヒロノリ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"芳賀, 猛","creatorNameLang":"ja"},{"creatorName":"ハガ, タケシ","creatorNameLang":"ja-Kana"},{"creatorName":"Haga, Takeshi","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Huang, Li","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Ikejiri, Ai","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Shimizu, Yuya","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Adachi, Takumi","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Toyama, Jun","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Miyata, Hironori","creatorNameLang":"en"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-06-21"}],"displaytype":"detail","filename":"2882haga.pdf","filesize":[{"value":"306.4 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"2882haga.pdf","url":"https://miyazaki-u.repo.nii.ac.jp/record/772/files/2882haga.pdf"},"version_id":"0bbf8625-13ac-4781-bfbe-ea60d5efc202"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"lectin, Momordica charantia, vaccine adjuvant","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Immunoadjuvant activity of crude lectin extracted from Momordica charantia seed","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Immunoadjuvant activity of crude lectin extracted from Momordica charantia seed","subitem_title_language":"en"},{"subitem_title":"ニガウリ種子由来粗精製レクチンの免疫アジュバント効果(臨床病理学)","subitem_title_language":"ja"}]},"item_type_id":"10001","owner":"5","path":["74","26"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2010-05-26"},"publish_date":"2010-05-26","publish_status":"0","recid":"772","relation_version_is_last":true,"title":["Immunoadjuvant activity of crude lectin extracted from Momordica charantia seed"],"weko_creator_id":"5","weko_shared_id":2},"updated":"2023-07-30T07:51:58.205488+00:00"}