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  1. 農学部
  1. 農学部
  2. 学術雑誌掲載論文 (農学部)

Effects of Tyrosine Kinase Inhibitor on the Motility and ATP Concentrations of Fowl Spermatozoa

http://hdl.handle.net/10458/734
http://hdl.handle.net/10458/734
7de4bf75-b259-4cd6-af95-1472aa4dfb8b
名前 / ファイル ライセンス アクション
ashizawa62.pdf ashizawa62.pdf (1.5 MB)
Item type 学術雑誌論文 / Journal Article(1)
公開日 2007-10-11
タイトル
タイトル Effects of Tyrosine Kinase Inhibitor on the Motility and ATP Concentrations of Fowl Spermatozoa
言語 en
タイトル
タイトル Tyrosine kinase and fowl sperm motility
言語 en
言語
言語 eng
キーワード
言語 ja
主題Scheme Other
キーワード 精子
キーワード
言語 en
主題Scheme Other
キーワード sperm, Spermatozoa, Protein phosphorylation / dephosphorylation, Tyrosine kinase, Motility
資源タイプ
資源タイプ journal article
著者 芦沢, 幸二

× 芦沢, 幸二

WEKO 932

ja 芦沢, 幸二

en Ashizawa, Koji

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Higashio, Mari

× Higashio, Mari

WEKO 5352

en Higashio, Mari

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Tsuzuki, Yasuhiro

× Tsuzuki, Yasuhiro

WEKO 2104
e-Rad 00236928

en Tsuzuki, Yasuhiro

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抄録
内容記述タイプ Abstract
内容記述 The possible role of tyrosine kinase in the regulation of fowl sperm motility was investigated by using a stable analogue of erbstatin, methyl 2,5-dihydroxycinnamate (2,5-MeC), a specific inhibitor of tyrosine kinase. This inhibited the motility of intact spermatozoa at 30°C in a dose- dependent manner. In contrast, the motility of demembranated spermatozoa was not inhibited by the same concentrations of 2,5-MeC. At 40°C, both intact and demembranated spermatozoa were almost immotile with or without 2,5-MeC. Additionally, intact spermatozoa, stimulated by the addition of Ca2+ or calyculin A, a specific inhibitor of protein phosphatases, lost their motility with the subsequent addition of 2,5-MeC at 40°C. However, unlike the motility, the ATP concentrations of spermatozoa were maintained in about 30-35 nmol ATP/10(9) cells during these incubation periods. The activity of tyrosine kinase of spermatozoa at 30°C, estimated by measuring the phosphorylation of a synthetic peptide substrate, RR-SRC, was 0.17 pmol/min/mg protein. This activity was lower than those of fowl testes and chick brain, but higher than that of chick liver. These results suggest that tyrosine kinase activity, which is not retained in the axoneme and/or accessory cytoskeletal components, may be involved in the maintenance of flagellar movement of fowl spermatozoa at 30°C.
言語 en
書誌情報 en : Molecular reproduction and development

巻 49, 号 1, p. 196-202, 発行日 1998
ISSN
収録物識別子タイプ ISSN
収録物識別子 1040452X
書誌レコードID
収録物識別子タイプ NCID
収録物識別子 AA10735246
著者版フラグ
出版タイプ AM
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