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Effect of emeriamine, an inhibitor of fatty acid oxidation, on metabolic fate of a geometrical isomer of linoleic acid in perfused rat liver
http://hdl.handle.net/10458/3531
http://hdl.handle.net/10458/353123a9ea95-7ac7-461a-95a4-fd3b278b0c11
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
FN_866.pdf (1.4 MB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||
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| 公開日 | 2011-12-02 | |||||
| タイトル | ||||||
| タイトル | Effect of emeriamine, an inhibitor of fatty acid oxidation, on metabolic fate of a geometrical isomer of linoleic acid in perfused rat liver | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| キーワード | Fatty acid oxidation inhibitor, Emeriamine, Ketone body production, Triacylglycerol secretion, Perfused rat liver | |||||
| 資源タイプ | ||||||
| 資源タイプ | journal article | |||||
| 著者 |
Fukuda, Nobuhiro
× Fukuda, Nobuhiro× Fukui, Masanori× Kai, Yasuko× Jayasooriya, Anura P.× Sakono, Masanobu× Maeda, Hideo× Ide, Takashi× Yamamoto, Kyosuke |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | To estimate the relative significance of exogenous vs. endogenous fatty acids in increasing hepatic triacylglycerol secretion following an inhibition of fatty acid oxidation by emeriamine, livers from 2-d-fasting rats were perfused with or without an inhibitor in the presence of a geometrical isomer of linoleate （linolelaidic acid, trans,trans-9,12-octadecadienoic acid）. Emeriamine added to the perfusion medium at 2 h of the recirculating perfusion period caused immediate and complete cessation of ketone body production while it increased triacylglycerol and cholesterol secretion by the liver without affecting uptake of exogenous linolelaidic acid. The increase in the triacylglycerol secretion by emeriamine was accompanied by a marked increase in the proportion of linolelaidic acid in this lipid molecule in the perfusate and in the liver. The calculated amounts of exogenous linolelaidate, compared with those of endogenous fatty acids in the secretory triacylglycerol, suggested that the former compared with the latter contributes more to the drug-mediated increase in triacylglycerol secretion. This drug caused a marked reduction of mitochondrial carnitine palmitoyltransferase activity in perfused liver. These results suggest that a blockade of fatty acid oxidation by emeriamine, through an inhibition of carnitine palmitoyltransferase, diverts predominantly the exogenous free fatty acids from oxidation to the esterification pathway and subsequently stimulates the synthesis and secretion of triacylglycerol-rich lipoproteins. | |||||
| 言語 | en | |||||
| 書誌情報 |
en : Journal of Nutritional Science and Vitaminology 巻 44, 号 4, p. 525-535, 発行日 1998-08 |
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| 出版者 | ||||||
| 出版者 | The Vitamin Society of Japan | |||||
| 言語 | en | |||||
| 出版者 | ||||||
| 出版者 | 日本ビタミン学会 | |||||
| 言語 | ja | |||||
| 出版者 | ||||||
| 出版者 | University of Tokyo Press | |||||
| 言語 | en | |||||
| 書誌レコードID | ||||||
| 収録物識別子タイプ | NCID | |||||
| 収録物識別子 | AA00703822 | |||||
| PubMed番号 | ||||||
| 関連タイプ | isIdenticalTo | |||||
| 識別子タイプ | PMID | |||||
| 関連識別子 | 9819713 | |||||
| 権利 | ||||||
| 言語 | ja | |||||
| 権利情報 | 日本ビタミン学会 | |||||
| 権利 | ||||||
| 言語 | ja | |||||
| 権利情報 | 本文データは学協会の許諾に基づきJournal@rchiveから複製したものである | |||||
| 他の資源との関係 | ||||||
| 関連名称 | http://dx.doi.org/10.3177/jnsv.44.525 | |||||
| 著者版フラグ | ||||||
| 出版タイプ | VoR | |||||
