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Hypertriglyceridemia and fatty liver of fasting rats after administration of emeriamine
http://hdl.handle.net/10458/3529
http://hdl.handle.net/10458/352909971308-9ffa-4e92-a591-fe6c6df80fa1
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
FN_869.pdf (1.7 MB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||
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| 公開日 | 2011-12-02 | |||||
| タイトル | ||||||
| タイトル | Hypertriglyceridemia and fatty liver of fasting rats after administration of emeriamine | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| キーワード | emeriamine, fatty liver, hypertriglyceridemia, lipoproteins, triglyceride | |||||
| 資源タイプ | ||||||
| 資源タイプ | journal article | |||||
| 著者 |
Maeda, Hideo
× Maeda, Hideo× Fujiwara, Miho× Fujita, Kazuko× Fukuda, Nobuhiro |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | The effect of emeriamine, a potent inhibitor of the entry of fatty acids into mitochondria on lipid metabolism, was examined. Emeriamine （10 mg/kg body weight） was orally administered to rats under the two different physiological conditions of a 2-day fast or refeeding with a high-carbohydrate diet after a 2-day fast. When rats were refed with a high-carbohydrate diet, serum and hepatic ketone bodies and the levels of free fatty acids decreased, and triglycerides significantly increased compared with fasting rats. However, no significant effect of emeriamine on serum and hepatic lipids was observed between two refeeding groups with or without emeriamine. Conversely, when emeriamine was administered to fasting rats, the levels of serum and hepatic triglycerides increased about 11- and 5-fold, respectively. However, the increased level of hepatic triglycerides was not accompanied by the activities of fatty acid synthetase and NADPH-generating enzymes. The analysis of serum lipoprotein revealed that very low-density lipoprotein consisted of triglyceride-rich particles and there were less apolipoproteins in the fasting rat given emeriamine. We also determined the 120-kDA protein content, which was probably dependent on lipogenesis. The level of 120-kDa protein was greatly increased with or without the administration of emeriamine after refeeding with a high-carbohydrate diet, but the concentration of 120-kDa protein was slight in the fasting rat with emeriamine. These results suggest that specific inhibition of fatty acid oxidation by emeriamine diverted the exogenous fatty acid to the esterification pathway, and induced fatty liver and hypertriglyceridemia under fasting conditions. | |||||
| 言語 | en | |||||
| 書誌情報 |
en : Journal of Nutritional Science and Vitaminology 巻 42, 号 2, p. 111-120, 発行日 1996-04 |
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| 出版者 | ||||||
| 出版者 | The Vitamin Society of Japan | |||||
| 言語 | en | |||||
| 出版者 | ||||||
| 出版者 | 日本ビタミン学会 | |||||
| 言語 | ja | |||||
| 出版者 | ||||||
| 出版者 | University of Tokyo Press | |||||
| 言語 | en | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 03014800 | |||||
| 書誌レコードID | ||||||
| 収録物識別子タイプ | NCID | |||||
| 収録物識別子 | AA00703822 | |||||
| PubMed番号 | ||||||
| 関連タイプ | isIdenticalTo | |||||
| 識別子タイプ | PMID | |||||
| 関連識別子 | 8780969 | |||||
| 権利 | ||||||
| 言語 | ja | |||||
| 権利情報 | 日本ビタミン学会 | |||||
| 権利 | ||||||
| 言語 | ja | |||||
| 権利情報 | 本文データは学協会の許諾に基づきJournal@rchiveから複製したものである | |||||
| 他の資源との関係 | ||||||
| 関連名称 | http://dx.doi.org/10.3177/jnsv.42.111 | |||||
| 著者版フラグ | ||||||
| 出版タイプ | VoR | |||||
