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Prognostic analysis of smoldering ATLL with skin eruptions based on genomic aberrations
http://hdl.handle.net/10458/00010601
http://hdl.handle.net/10458/00010601b73339f9-1657-4326-92d9-ad3cf9d99fde
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
本文 (4.7 MB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||
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| 公開日 | 2023-04-26 | |||||
| タイトル | ||||||
| タイトル | Prognostic analysis of smoldering ATLL with skin eruptions based on genomic aberrations | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | Smoldering ATLL with skin eruption | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | STAT3 mutation | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | Genomic aberrations | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| 著者 |
井上, 健太郎
× 井上, 健太郎× 山下, 篤× 森下, 和広× Mochida, Kosuke× Nakahata, Shingo× Suzuki, Yutaka× Moriguchi, Sayaka× Amano, Masahiro |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Background Patients with smoldering ATLL often present with a skin eruption due to skin infiltration of ATLL cells. Although skin eruption type is known to be associated with prognosis based on its pattern, it is unknown why different types of skin eruptions are associated with different prognoses. Objective Genomic analysis of patients with skin eruptions of smoldering ATLL will be performed to determine the mechanism of ATLL development and its association with prognosis. Methods DNA from skin biopsy specimens was used for targeted sequencing of 280 genes to examine the association between genomic variation and prognosis. Results Due to the small number of smoldering ATLL patients （27 cases）, we could not find a clear relationship between skin eruption and prognosis in this study. Genomic analysis identified 247 genomic variants （108 genes）, with an average of 9.2 variants and 3.2 variants as driver genes. Pathway analysis of the driver genes showed activation of the pathway associated with HTLV-1 infection, as well as activation of the signaling pathway observed throughout ATLL. Furthermore, multivariate analysis identified age>70 years and STAT3 mutation as prognostic risk factors and TBL1XR1 mutation as a risk factor for progression-free survival. Conclusion Although the small number of patient samples did not allow us to determine a prognostic association with skin eruption, STAT3 mutation was identified as a prognostic risk factor for smoldering ATLL with skin eruption. Further studies are needed to increase the number of patients with this disease. |
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| 書誌情報 |
en : Journal of Dermatological Science 巻 109, 号 2, p. 80-88, 発行日 2023-02 |
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| 出版者 | ||||||
| 出版者 | Elsevier | |||||
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| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 09231811 | |||||
| DOI | ||||||
| 関連タイプ | isIdenticalTo | |||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | https://doi.org/10.1016/j.jdermsci.2023.02.001 | |||||
| 権利 | ||||||
| 権利情報 | © 2023 The Authors. Published by Elsevier B.V. on behalf of Japanese Society for Investigative Dermatology. | |||||
| 関連サイト | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | https://doi.org/10.1016/j.jdermsci.2023.02.001 | |||||
| 関連名称 | Publisher's web site | |||||
| フォーマット | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | application/pdf | |||||
| 著者版フラグ | ||||||
| 出版タイプ | VoR | |||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
