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Relationship between Hemoglobin Levels Corrected by Interdialytic Weight Gain and Mortality in Japanese Hemodialysis Patients: Miyazaki Dialysis Cohort Study
http://hdl.handle.net/10458/00010504
http://hdl.handle.net/10458/0001050428e38339-3452-4143-a5c6-51f4c89221cc
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本文 (1.5 MB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||
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| 公開日 | 2023-02-20 | |||||
| タイトル | ||||||
| タイトル | Relationship between Hemoglobin Levels Corrected by Interdialytic Weight Gain and Mortality in Japanese Hemodialysis Patients: Miyazaki Dialysis Cohort Study | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ | journal article | |||||
| 著者 |
岩切, 太幹志
× 岩切, 太幹志× 小松, 弘幸× 北村, 和雄× 藤元, 昭一× 戸井田, 達典× 佐藤, 祐二 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Background: Although hemoglobin （Hb） levels are affected by a change in the body fluid status, the relationship between Hb levels and mortality while taking interdialytic weight gain （IDWG） at blood sampling into account has not yet been examined in hemodialysis patients. | |||||
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| 内容記述タイプ | Abstract | |||||
| 内容記述 | Study design: Cohort study. | |||||
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| 内容記述タイプ | Abstract | |||||
| 内容記述 | Setting, Participants: Data from the Miyazaki Dialysis cohort study, including 1375 prevalent hemodialysis patients （median age （interquartile range）, 69 （60–77） years, 42.3% female）. | |||||
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| 内容記述タイプ | Abstract | |||||
| 内容記述 | Predictor: Patients were divided into 5 categories according to baseline Hb levels and two groups based on the median value of IDWG rates at blood sampling at pre-HD on the first dialysis session of the week. | |||||
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| 内容記述タイプ | Abstract | |||||
| 内容記述 | Outcomes: All-cause and cardiovascular mortalities during a 3-year follow-up. | |||||
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| 内容記述タイプ | Abstract | |||||
| 内容記述 | Measurements: Hazard ratios were estimated using a Cox model for the relationship between Hb categories and mortality, and adjusted for potential confounders such as age, sex, dialysis duration, erythropoiesis-stimulating agent dosage, Kt/V, comorbid conditions, anti-hypertensive drug use, serum albumin, serum C-reactive protein, serum ferritin, and serum intact parathyroid hormone. Patients with Hb levels of 9–9.9 g/dL were set as our reference category. | |||||
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| 内容記述タイプ | Abstract | |||||
| 内容記述 | Results: A total of 246 patients （18%） died of all-cause mortality, including 112 cardiovascular deaths. Lower Hb levels （<9.0g/dL） were associated with all-cause mortality （adjusted HRs 2.043 [95% CI, 1.347–3.009]）, while Hb levels were not associated with cardiovascular mortality. When patients were divided into two groups using the median value of IDWG rates （high IDWG, ≥5.4% and low IDWG, <5.4%）, the correlation between lower Hb levels and all-cause mortality disappeared in high IDWG patients, but was maintained in low IDWG patients （adjusted HRs 3.058 [95% CI,1.575–5.934]）. On the other hand, higher Hb levels （≥12g/dL） were associated with cardiovascular mortality in high IDWG patients （adjusted HRs 2.724 [95% CI, 1.010–7.349]）, but not in low IDWG patients. | |||||
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| 内容記述タイプ | Abstract | |||||
| 内容記述 | Conclusion: In hemodialysis patients, target Hb levels may need to be selected in consideration of IDWG at blood sampling. | |||||
| 書誌情報 |
en : PLOS ONE 巻 12, 号 1, p. e0169117, 発行日 2017-01-03 |
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| 出版者 | ||||||
| 出版者 | Public Library of Science | |||||
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| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 19326203 | |||||
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| 関連タイプ | isIdenticalTo | |||||
| 識別子タイプ | PMID | |||||
| 関連識別子 | 28046068 | |||||
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| 関連タイプ | isIdenticalTo | |||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | https://doi.org/10.1371/journal.pone.0169117 | |||||
| 権利 | ||||||
| 権利情報 | © 2017 Toida et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. | |||||
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| 識別子タイプ | DOI | |||||
| 関連識別子 | https://doi.org/10.1371/journal.pone.0169117 | |||||
| 関連名称 | Publisher's web site | |||||
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| 内容記述タイプ | Other | |||||
| 内容記述 | application/pdf | |||||
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| 出版タイプ | VoR | |||||
