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Efficacy of folic acid supplementation on DNA oxidative damage repair: a Randomized,Placebo Controlled Clinical Trial in Inner Mongolia
http://hdl.handle.net/10458/00005553
http://hdl.handle.net/10458/000055536490edec-d0eb-4cff-8f0e-0b77ca461d2d
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
本文 (632.2 kB)
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| Item type | その他 / Others(1) | |||||
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| 公開日 | 2020-06-21 | |||||
| タイトル | ||||||
| タイトル | Efficacy of folic acid supplementation on DNA oxidative damage repair: a Randomized,Placebo Controlled Clinical Trial in Inner Mongolia | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | Arsenic, 8-OHdG/Cr, folic acid, R andomized clinical trial | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_1843 | |||||
| 資源タイプ | other | |||||
| 著者 |
Xiaojuan, Guo
× Xiaojuan, Guo× Huan, Cui× Haiyang, Zhang× Zheng, Zhang× Xiaoju, Guan× Zuopeng, Yang× Guangyun, Mao |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | A randomized, double-blind, placebo controlled clinical trial was conducted in arsenic exposed population in Inner Mongolia to know the efficacy of folic acid supplementation on arsenic-inducted DNA d o xidative damage. Methods: In this randomized clinical trial （RCT）, a total of 450 participants were enrolled and randomly assigned to 3 groups to receive folic acid （FA） 0.4mg/day （Low FA）, 0.8mg/day （High-FA） or placebo （Control） for 8 weeks. The urine 8-hydroxy-2'-deoxyguanosine（8-OHdG） and creatinine （Cr） concentration at pre- and post-FAS were measured with enzyme-linked immunosorbent assay （ELISA） kit and high-performance liquid chromatography （HPLC）, respectively. A multivariate general linear model （GLM） was applied to assess the individual effects of FA and the joint effects between FA and hypercholesterolemia on oxidative damage improvements. This clinical trial was registered with ClinicalTrials.gov, number NCT02235948. Results: Compared with placebo, after adjusted for some potential confounding factors, the urinary 8-OHdG/Cr concentration significantly decreased after 56 days FAS in a dose-response fashion（P<0.001）. A joint effect between hypercholesterolemia and FAS on urinary 8-OHdG/Cr reduction was also observed （P=0.001）. Conclusions: The present study demonstrates that FAS is beneficial for DNA oxidative damage repair. People with hypercholesterolemia might have better effects on the improvement of DNA lesion. |
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| 言語 | en | |||||
| 書誌情報 |
en : 4th InternationalArsenic Symposium in MIYAZAKI 2015 p. 56-61, 発行日 2015-10 |
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| 出版者 | ||||||
| 出版者 | University of Miyazaki, IRISH | |||||
| 言語 | en | |||||
| 著者版フラグ | ||||||
| 出版タイプ | VoR | |||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
