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Intracellular Ca2+ signaling pathway is involved in light-induced phase advance, but may not be in phase delay, of the circadian melatonin rhythm in chick pineal cell
http://hdl.handle.net/10458/1920
http://hdl.handle.net/10458/1920fd6ae48c-ec67-4cdc-878c-83c6b5d323c1
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
jpr30-4.pdf (1.3 MB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||
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| 公開日 | 2009-03-02 | |||||
| タイトル | ||||||
| タイトル | Intracellular Ca2+ signaling pathway is involved in light-induced phase advance, but may not be in phase delay, of the circadian melatonin rhythm in chick pineal cell | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| キーワード | Circadian rhythms, Melatonin, Pineal cell | |||||
| 資源タイプ | ||||||
| 資源タイプ | journal article | |||||
| 著者 |
Nakahara, Keiko
× Nakahara, Keiko× Murakami, Noboru× Takigami, Eri× Nasu, Tetsuo× Murakami, Takayuki× Shiota, Kunio |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Chick pineal cells have photoreceptive, circadian clock and melatonin synthetic capacities, and express circadian oscillation of melatonin release in vitro. Light pulses cause phase-dependent phase shift of the melatonin rhythm. The purpose of this study was to address the questions whether intracellular calcium is involved in both light-induced phase advance and delay. Thapsigargin and cyclopiazonic acid, which deplete the intracellular calcium stores, blocked the light-induced phase advance in a dose-dependent manner. The pulses of ryanodine receptor antagonist （dantrolene sodium or ruthenium red） also blocked the light-induced phase advance. Most agents did not cause a significant phase shift by themselves. On the other hand, all the agents used, failed to block the light-induced phase delay, even if the magnitude of phase delay was decreased using low intensity light. An antagonist of nitric oxide synthase blocked neither light-induced phase advance nor phase delay. These results indicate the following possibilities: （1） the mechanism of light-induced phase advance and delay may be different in chick pineal cells, or （2） if intracellular calcium is involved in both light-induced phase advance and delay, the sensitivity to light and/or agents used in this study may differ according to Zeitgeber time. | |||||
| 言語 | en | |||||
| 書誌情報 |
en : Journal of pineal research 巻 30, 号 4, p. 234-242, 発行日 2001 |
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| 出版者 | ||||||
| 出版者 | Blackwell Publishing | |||||
| 言語 | en | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 07423098 | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 1600079X | |||||
| 書誌レコードID | ||||||
| 収録物識別子タイプ | NCID | |||||
| 収録物識別子 | AA10641255 | |||||
| 著者版フラグ | ||||||
| 出版タイプ | AM | |||||
