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One-day high-fat diet induces inflammation in the nodose ganglion and hypothalamus of mice
http://hdl.handle.net/10458/5735
http://hdl.handle.net/10458/573589850ad2-f738-4135-8b07-5acee7a4d3e8
| Item type | 学術雑誌論文 / Journal Article(1) | |||||||||||
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| 公開日 | 2020-06-21 | |||||||||||
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| タイトル | One-day high-fat diet induces inflammation in the nodose ganglion and hypothalamus of mice | |||||||||||
| 言語 | en | |||||||||||
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| 言語 | eng | |||||||||||
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| 言語 | en | |||||||||||
| キーワード | High-fat diet, Inflammation, Ghrelin, Nodose ganglion, Vagotomy | |||||||||||
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| 資源タイプ | journal article | |||||||||||
| アクセス権 | ||||||||||||
| アクセス権 | metadata only access | |||||||||||
| 著者 |
T., M. Zaved Waise
× T., M. Zaved Waise× 十枝内, 厚次× Naznin, Farhana× NamKoong, Cherl× Moin, Abu Saleh Md.× 迫田, 秀之× 中里, 雅光
WEKO
21757
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| 内容記述タイプ | Abstract | |||||||||||
| 内容記述 | A high-fat diet （HFD） induces inflammation in systemic organs including the hypothalamus, resulting in obesity and diabetes. The vagus nerve connects the visceral organs and central nervous system, and the gastric-derived orexigenic peptide ghrelin transmits its starvation signals to the hypothalamus via the vagal afferent nerve. Here we investigated the inflammatory response in vagal afferent neurons and the hypothalamus in mice following one day of HFD feeding. This treatment increased the number of macrophages/microglia in the nodose ganglion and hypothalamus. Furthermore, one-day HFD induced expression of Toll-like receptor 4 in the goblet cells of the colon and upregulated mRNA expressions of the proinflammatory biomarkers Emr1, Iba1, Il6, and Tnfα in the nodose ganglion and hypothalamus. Both subcutaneous administration of ghrelin and celiac vagotomy reduced HFD-induced inflammation in these tissues. HFD intake triggered inflammatory responses in the gut, nodose ganglion, and subsequently in the hypothalamus within 24 h. These findings suggest that the vagal afferent nerve may transfer gut-derived inflammatory signals to the hypothalamus via the nodose ganglion, and that ghrelin may protect against HFD-induced inflammation. | |||||||||||
| 言語 | en | |||||||||||
| 書誌情報 |
en : Biochemical and Biophysical Research Communications 巻 464, 号 4, p. 1157-1162, 発行日 2015-09 |
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| 出版者 | Elsevier | |||||||||||
| 言語 | en | |||||||||||
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| 収録物識別子タイプ | ISSN | |||||||||||
| 収録物識別子 | 0006291X | |||||||||||
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| 出版タイプ | NA | |||||||||||
