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A synthetic tryptophan metabolite reduces hemorrhagic area and inflammation after pulmonary radiofrequency ablation in rabbit nonneoplastic lungs
http://hdl.handle.net/10458/5471
http://hdl.handle.net/10458/5471d48bbd00-a347-4093-8708-e6a187d40641
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2020-06-21 | |||||
| タイトル | ||||||
| タイトル | A synthetic tryptophan metabolite reduces hemorrhagic area and inflammation after pulmonary radiofrequency ablation in rabbit nonneoplastic lungs | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| キーワード | Lungs, Radiofrequency ablation, Inflammation, CD163, Tranilast | |||||
| 資源タイプ | ||||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| 著者 |
中田, 博
× 中田, 博× 山下, 篤× 黒木, 正臣× 古小路, 英二× 内野, 典子× 浅沼, 武敏× 浅田, 祐士郎× 田村, 正三 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Purpose The purpose of this study was to determine the effect of a synthetic tryptophan metabolite, tranilast [N-（3,4-dimethoxycinnamoyl）-anthranilic acid], on inflammatory and hemorrhagic areas after pulmonary radiofrequency ablation （RFA） in rabbits. Materials and methods Percutaneous RFA using a 17-gauge LeVeen electrode was performed in normal rabbit lungs. The rabbits were divided into tranilast-treated （300 mg/kg/day, orally） and control groups （n = 24/group）. The effects of tranilast were evaluated using multidetector-row computed tomography （CT）, histology, and immunohistochemistry immediately after RFA on days 1, 7, 14, and 28. Results Oral administration of tranilast significantly reduced the size of ablated lesions assessed using CT and histology on days 7 and 14. Furthermore, it reduced the hemorrhagic areas on day 7 and inflammatory areas on day 14, but did not affect the areas of coagulation necrosis on days 1, 7, 14, and 28. Immunohistochemical analysis showed an increase in the ratio of CD163-positive macrophage areas to rabbit macrophage （RAM11）-positive pan-macrophage areas and a decrease in the number of nuclear factor-κB-positive nuclei and CD31-positive microvessels in the tranilast group on days 7 and/or 14. Conclusions The results suggest that tranilast modulates the repair process after pulmonary RFA through macrophage accumulation, suppression of inflammation, and angiogenesis. |
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| 言語 | en | |||||
| 書誌情報 |
en : Japanese Journal of Radiology 巻 32, 号 3, p. 145-154, 発行日 2014-03 |
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| 出版者 | ||||||
| 出版者 | 日本医学放射線学会 | |||||
| 言語 | ja | |||||
| 出版者 | ||||||
| 出版者 | Springer Japan | |||||
| 言語 | en | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 18671071 | |||||
| DOI | ||||||
| 関連タイプ | isVersionOf | |||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | https://doi.org/10.1007/s11604-014-0282-4 | |||||
| 著者版フラグ | ||||||
| 出版タイプ | NA | |||||
