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Increased plasma levels of the mature and intermediate forms of adrenomedullin in obesity
http://hdl.handle.net/10458/5469
http://hdl.handle.net/10458/5469f422c5e5-552c-40a9-9b16-c2dcf19122a6
| Item type | 学術雑誌論文 / Journal Article(1) | |||||||||||
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| 公開日 | 2020-06-21 | |||||||||||
| タイトル | ||||||||||||
| タイトル | Increased plasma levels of the mature and intermediate forms of adrenomedullin in obesity | |||||||||||
| 言語 | en | |||||||||||
| 言語 | ||||||||||||
| 言語 | eng | |||||||||||
| キーワード | ||||||||||||
| 言語 | en | |||||||||||
| 主題Scheme | Other | |||||||||||
| 主題 | Body mass index, Insulin sensitivity, Metabolic disorder | |||||||||||
| 資源タイプ | ||||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||||
| 資源タイプ | journal article | |||||||||||
| アクセス権 | ||||||||||||
| アクセス権 | metadata only access | |||||||||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||||||||
| 著者 |
野村, 郁夫
× 野村, 郁夫× 加藤, 丈司× 渡嘉敷, 真理子× 北村, 和雄
WEKO
7929
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| 抄録 | ||||||||||||
| 内容記述タイプ | Abstract | |||||||||||
| 内容記述 | Adrenomedullin （AM） is a cardiovascular protective peptide produced in various organs and tissues including adipose tissue. In the present study, we measured the plasma AM levels of subjects with or without obesity by two assay methods to separately evaluate the biologically active AM–NH_2 and the intermediate form of AM–glycine （AM–Gly）. We measured the total AM and AM–NH_2 levels of plasma in 52 obese and 172 non-obese residents of a Japanese community, who received regular health check-ups and had no overt cardiovascular disease. AM–Gly values were obtained by subtracting AM–NH_2 levels from those of total AM. Both the AM–NH_2 and AM–Gly levels of the subjects with obesity were higher than those without obesity, and significant relationships were noted between body mass index （BMI） and the plasma levels of the two molecular forms of AM in a simple regression analysis. Moreover, the significant factors identified by multivariate analyses were BMI and serum triglyceride for AM–NH_2 and diastolic blood pressure, insulin, high-density lipoprotein-cholesterol, and plasma renin activity for AM–Gly. These results suggest active roles for the two molecular forms of AM in metabolic disorders associated with obesity in subjects without overt cardiovascular disease. | |||||||||||
| 内容記述 | ||||||||||||
| 内容記述タイプ | Other | |||||||||||
| 内容記述 | Citation: Nomura I, Kato J, Tokashiki M, Kitamura K. Increased plasma levels of the mature and intermediate forms of adrenomedullin in obesity. Regul Pept. 2009 Nov 27;158(1-3):127-31. doi: 10.1016/j.regpep.2009.08.003. Epub 2009 Aug 23. PMID: 19706311. |
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| 言語 | en | |||||||||||
| 書誌情報 |
en : Regulatory Peptides 巻 158, 号 1-3, p. 127–131-127–131, 発行日 2009-11-27 |
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| 出版者 | ||||||||||||
| 出版者 | Elsevier | |||||||||||
| 言語 | en | |||||||||||
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| 収録物識別子タイプ | ISSN | |||||||||||
| 収録物識別子 | 01670115 | |||||||||||
| DOI | ||||||||||||
| 関連タイプ | isVersionOf | |||||||||||
| 識別子タイプ | DOI | |||||||||||
| 関連識別子 | https://doi.org/10.1016/j.regpep.2009.08.003 | |||||||||||
