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The expression of Hedgehog genes (Ihh, Dhh) and Hedgehog target genes (Ptc1, Gli1, COUP-TFII) is primarily regulated by estrogen receptor α-dependent pathway in the uterus of immature female SD rats
http://hdl.handle.net/10458/718
http://hdl.handle.net/10458/718fe5ffe70-0d84-45fb-8420-fd7e84831189
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
ashizawa85.pdf (2.2 MB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||
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| 公開日 | 2007-10-10 | |||||
| タイトル | ||||||
| タイトル | The expression of Hedgehog genes (Ihh, Dhh) and Hedgehog target genes (Ptc1, Gli1, COUP-TFII) is primarily regulated by estrogen receptor α-dependent pathway in the uterus of immature female SD rats | |||||
| 言語 | en | |||||
| タイトル | ||||||
| タイトル | The expression of Hedgehog genes (Ihh, Dhh) and Hedgehog target genes (Ptc1, Gli1, Coup-TfII) is affected by estrogenic stimuli in the uterus of immature female rats|Transcriptional regulation of Ihh and Dhh via ER | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 言語 | ja | |||||
| キーワード | 精子 | |||||
| キーワード | ||||||
| 言語 | en | |||||
| キーワード | sperm, Estrogen receptor, Uterus, Indian hedgehog, Desert hedgehog, Patched 1 Gli 1, COUP-TFII | |||||
| 資源タイプ | ||||||
| 資源タイプ | journal article | |||||
| 著者 |
芦沢, 幸二
× 芦沢, 幸二× Seiichi, Katayama× Gohma, Hiroshi× Fukuhara, Tadahiro× Narumi, Kazunori× Tsuzuki, Yasuhiro× Tatemoto, Hideki× Nakada, Tadashi× Nagai, Kenji |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | The objective of this study was to investigate the effects of estrogen receptor （ER） subtype-selective agonists and an ER antagonist on the expression of Hedgehog genes （Indian hedgehog: Ihh; Desert hedgehog: Dhh） and Hedgehog target genes （Patched 1: Ptc1; Gli1; chicken ovalbumin upstream promoter transcription factor II: COUP-TFII） in the rat uterus. Immature female rats were administered once with 17α-ethynyl estradiol （EE, an ER agonist）, propyl pyrazole triole （PPT, an ERα-selective agonist）, diarylpropionitrile （DPN, an ERβ-selective agonist）, or ICI 182,780 （an ER antagonist）. Expression of mRNA for Ihh, Dhh, and Ptc1 was dose-dependently downregulated by EE in the uterus of immature rats, mediated by ER as confirmed by coadministration of ICI 182,780. PPT downregulated the transcription of Ihh, Dhh, Ptc1, Gli1, and COP-TFII, indicating that expression of these genes was regulated by the ERα-dependent pathway. DPN also downregulated the transcription of Ihh and Dhh, although the effect was weaker than that of PPT, indicating that the regulation of uterine Ihh and Dhh transcription was also affected by the ERβ-dependent pathway. These results suggest that the expression of Hedgehog genes （Ihh, Dhh） and Hedgehog target genes （Ptc1, Gli1, COUP-TFII） is regulated primarily via the ERα-dependent pathway in the uterus of immature female rats. | |||||
| 言語 | en | |||||
| 書誌情報 |
en : Toxicology and applied pharmacology 巻 217, 号 3, p. 375-383, 発行日 2006-12-15 |
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| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 0041008X | |||||
| 書誌レコードID | ||||||
| 収録物識別子タイプ | NCID | |||||
| 収録物識別子 | AA00864435 | |||||
| 著者版フラグ | ||||||
| 出版タイプ | AM | |||||
