WEKO3
アイテム
新規摂食調整ペプチド、グレリンのイヌにおける生理機能に関する研究
http://hdl.handle.net/10458/952
http://hdl.handle.net/10458/952c6529dc3-bf2f-407c-b162-eaca9de4ae4f
| 名前 / ファイル | ライセンス | アクション |
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DT_横山政幸.pdf (3.8 MB)
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| アイテムタイプ | 学位論文 / Thesis or Dissertation(1) | |||||
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| 公開日 | 2007-11-22 | |||||
| タイトル | ||||||
| タイトル | 新規摂食調整ペプチド、グレリンのイヌにおける生理機能に関する研究 | |||||
| 言語 | ja | |||||
| タイトル | ||||||
| タイトル | Physiological role of ghrelin in dogs | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_46ec | |||||
| 資源タイプ | thesis | |||||
| 著者 |
横山, 政幸
× 横山, 政幸 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Ghrelin has recently been isolated from rat and human stomach as an endogenous ligand for the growth hormone(GH)secretagog receptor. Using beagle dogs, I investigated the distribution of ghrelin in the stomach and its possible role. RIA for plasma canine ghrelin was validated. Administration of ghrelin to dogs promptly increased circulating GH concentrations, although this effect was transitory and was maintained for only 20 min. Ghrelin was localized in the stomach fundus and body, but none was detected in either the pylorus or cardia. Administration of ghrelin at a dose of 20 μg/kg increased the daily food intake of beagle dogs. Plasma ghrelin levels peaked just before meal times, and then returned to basal levels. Obese dogs had higher plasma grelin levels than did normal and lean dogs. Obesity resulted in a significant increase in plazma free fat acid, cholesterol and high density lipoprotein cholesterol. These results indicate that ghrelin is a potent GH secretagog in dogs. The distribution of ghrelin-immunoreactive cells in the canine stomach resembles that of both the murine and human stomach. Ghrelin participates in the control of feeding behavior and energy homeostasis in dogs and may, therfore, be involved in the development of obesity. | |||||
| 言語 | en | |||||
| 内容記述 | ||||||
| 値 | 山口大学大学院連合獣医学研究科博士論文 | |||||
| 内容記述 | ||||||
| 言語 | ja | |||||
| 著者版フラグ | ||||||
| 出版タイプ | VoR | |||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
