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血液凝固VIII因子の血中濃度の増加は家兎静脈血栓形成を促進させる : 血液凝固XI因子、von Willebrand因子および組織因子の関与
http://hdl.handle.net/10458/4705
http://hdl.handle.net/10458/4705627ca567-563b-4aea-b2df-1e0400e67190
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学位論文審査結果の要旨 (43.2 kB)
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論文要旨 (176.5 kB)
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博士学位論文 (1.6 MB)
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| Item type | 学位論文 / Thesis or Dissertation(1) | |||||
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| 公開日 | 2013-12-25 | |||||
| タイトル | ||||||
| タイトル | Elevated plasma factor VIII enhances venous thrombus formation in rabbits : contribution of factor XI, von Willebrand factor and tissue factor | |||||
| 言語 | en | |||||
| タイトル | ||||||
| タイトル | 血液凝固VIII因子の血中濃度の増加は家兎静脈血栓形成を促進させる : 血液凝固XI因子、von Willebrand因子および組織因子の関与 | |||||
| 言語 | ja | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | Deep venous thrombosis, factor VIII, factor XI, von Willebrand factor | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_db06 | |||||
| 資源タイプ | doctoral thesis | |||||
| アクセス権 | ||||||
| アクセス権 | open access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||
| 著者 |
杉田, 千泰
× 杉田, 千泰 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Elevated plasma levels of factor VIII (FVIII) are associated with increased risk of deep venous thrombosis. The aim of this study is to elucidate how elevated FVIII levels affect venous thrombus formation and propagation in vivo. We examined rabbit plasma FVIII activity, plasma thrombin generation, whole blood coagulation, platelet aggregation and venous wall thrombogenicity before and one hour after an intravenous infusion of recombinant human FVIII (rFVIII). Venous thrombus induced by the endothelial denudation of rabbit jugular veins was histologically assessed. Thrombus propagation was evaluated as indocyanine green fluorescence intensity. Argatroban, a thrombin inhibitor, and neutralized antibodies for tissue factor (TF), factor XI (FXI), and von Willebrand factor (VWF) were infused before or after thrombus induction to investigate their effects on venous thrombus formation or propagation. Recombinant FVIII (100 IU/kg) increased rabbit plasma FVIII activity two-fold and significantly enhanced whole blood coagulation and total plasma thrombin generation, but did not affect initial thrombin generation time, platelet aggregation and venous wall thrombogenicity. The rFVIII infusion also increased the size of venous thrombus one hour after thrombus induction. Argatroban and the antibodies for TF, FXI or VWF inhibited such enhanced thrombus formation and all except TF suppressed thrombus propagation. In conclusion, elevated plasma FVIII levels enhance venous thrombus formation and propagation. Excess thrombin generation by FXI and VWF-mediated FVIII recruitment appear to contribute to the growth of FVIII-driven venous thrombus. | |||||
| 言語 | en | |||||
| 内容記述 | ||||||
| ja | ||||||
| 本論文に関連する研究論文 Sugita C, Yamashita A, Matsuura Y, Iwakiri T, Okuyama N, Matsuda S, Matsumoto T, Inoue O, Harada A, Kitazawa T, Hattori K, Shima M, Asada Y. Elevated plasma factor VIII enhances venous thrombus formation in rabbits: contribution of factor XI, von Willebrand factor and tissue factor. Thromb Haemost. 2013 Jul;110(1):62-75. doi: 10.1160/TH13-01-0069. Epub 2013 May 2. PMID: 23636277. |
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| 学位名 | ||||||
| 言語 | ja | |||||
| 学位名 | 博士(医学) | |||||
| 学位授与機関 | ||||||
| 学位授与機関識別子Scheme | kakenhi | |||||
| 学位授与機関識別子 | 17601 | |||||
| 言語 | ja | |||||
| 学位授与機関名 | 宮崎大学 | |||||
| 学位授与年度 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | 2013年度 | |||||
| 言語 | ja | |||||
| 学位授与年月日 | ||||||
| 学位授与年月日 | 2013-09-20 | |||||
| 学位授与番号 | ||||||
| 学位授与番号 | 医博甲第413号 | |||||
| 他の資源との関係 | ||||||
| 関連名称 | http://hdl.handle.net/10458/4640 | |||||
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| 出版タイプ | VoR | |||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
| リンク |
Elevated plasma factor VIII enhances venous thrombus formation in rabbits : contribution of factor XI, von Willebrand factor and tissue factor
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