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1,5-アンヒドログルシトールによる周術期の血糖評価の有用性についての検討
http://hdl.handle.net/10458/4585
http://hdl.handle.net/10458/4585d3527c99-8d9a-4968-98e0-b3022ed7fb20
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論文要旨 (79.4 kB)
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学位論文審査結果の要旨 (45.0 kB)
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博士学位論文 (873.6 kB)
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| Item type | 学位論文 / Thesis or Dissertation(1) | |||||
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| 公開日 | 2013-08-23 | |||||
| タイトル | ||||||
| タイトル | Evaluating the Role of Serum 1,5-Anhydroglucitol Concentrations as an Indicator of Hyperglycemic Changes in Diabetic and Non Diabetic Surgical Patients | |||||
| 言語 | en | |||||
| タイトル | ||||||
| タイトル | 1,5-アンヒドログルシトールによる周術期の血糖評価の有用性についての検討 | |||||
| 言語 | ja | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | 1,5-anhydroglucitol (1,5-AG), Plasma glucose concentrations, Operation, Glycemic control, Diabetes mellitus | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_db06 | |||||
| 資源タイプ | doctoral thesis | |||||
| アクセス権 | ||||||
| アクセス権 | open access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||
| 著者 |
田村, 隆二
× 田村, 隆二 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Purpose : We investigated the relationship between plasma glucose and serum 1,5-anhydroglucitol (l,5-AG) concentrations in surgical patients to determine the role of 1,5-AG concentrations in perioperative glycemic control. Methods : We enrolled 57 patients (19 with and 38 without diabetes) in the study, who underwent hepatectomy under general anesthesia with sevoflurane and remifentanil. Plasma glucose and serum 1,5-AG concentrations were measured and their correlations were evaluated. Results : In all patients, plasma glucose concentrations increased significantly during hepatectomy, but serum 1,5-AG concentrations declined after surgery. Linear regression analysis revealed a weak but significant correlation between the decrease rate of 1,5-AG concentrations and the increase rate of plasma glucose concentrations. Regression analyses revealed this concentration to be more intense in patients without diabetes than in all patients, whereas no correlation was observed in patients with diabetes. These results suggest that serum 1,5-AG concentrations decrease significantly in proportion to increase in plasma glucose concentrations in patients without diabetes, but are less sensitive to such changes in patients with diabetes. Consequently, this indicates that preoperative serum 1,5-AG concentrations in patients with diabetes are too low to be influenced by glycemic fluctuations. In both patient groups, decreased 1,5-AG concentrations did not normalize until 72 h after initiation of surgery. Conclusion : Measurement of 1,5-AG concentrations may be a useful for evaluating glycemic control during anesthesia in patients with normal glycemic metabolism; however, this approach may not be as useful in patients with diabetes as in those without diabetes. |
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| 言語 | en | |||||
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| 本論文に関連する研究論文 Tamura R, Tsuneyoshi I (2013) Evaluating the Role of Serum 1,5-Anhydroglucitol Concentrations as an Indicator of Hyperglycemic Changes in Diabetic and Non Diabetic Surgical Patients. J Anesthe Clinic Res 4: 298. doi:10.4172/2155-6148.1000298 |
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| 学位名 | ||||||
| 言語 | ja | |||||
| 学位名 | 博士(医学) | |||||
| 学位授与機関 | ||||||
| 学位授与機関識別子Scheme | kakenhi | |||||
| 学位授与機関識別子 | 17601 | |||||
| 言語 | ja | |||||
| 学位授与機関名 | 宮崎大学 | |||||
| 学位授与年度 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | 2013年度 | |||||
| 言語 | ja | |||||
| 学位授与年月日 | ||||||
| 学位授与年月日 | 2013-06-28 | |||||
| 学位授与番号 | ||||||
| 学位授与番号 | 医博甲第412号 | |||||
| 他の資源との関係 | ||||||
| 関連名称 | http://hdl.handle.net/10458/4584 | |||||
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| 出版タイプ | VoR | |||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
| リンク |
Evaluating the Role of Serum 1,5-Anhydroglucitol Concentrations as an Indicator of Hyperglycemic Changes in Diabetic and Non Diabetic Surgical Patients
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