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Characteristics and clustering of human ribosomal protein genes
http://hdl.handle.net/10458/1811
http://hdl.handle.net/10458/1811633ea9d4-0711-42bf-804e-1c3c8425ef51
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
BMC06 Ishii.pdf (940.2 kB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||
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| 公開日 | 2009-02-05 | |||||
| タイトル | ||||||
| タイトル | Characteristics and clustering of human ribosomal protein genes | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ | journal article | |||||
| 著者 |
Ishii, Kyota
× Ishii, Kyota× Washio, Takanori× Uechi, Tamayo× Yoshihama, Maki× Kenmochi, Naoya× Tomita, Masaru |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Background: The ribosome is a central player in the translation system, which in mammals consists of four RNA species and 79 ribosomal proteins （RPs）. The control mechanisms of gene expression and the functions of RPs are believed to be identical. Most RP genes have common promoters and were therefore assumed to have a unified gene expression control mechanism. Results: We systematically analyzed the homogeneity and heterogeneity of RP genes on the basis of their expression profiles, promoter structures, encoded amino acid compositions, and codon compositions. The results revealed that （1） most RP genes are coordinately expressed at the mRNA level, with higher signals in the spleen, lymph node dissection （LND）, and fetal brain. However, 17 genes, including the P protein genes （RPLP0, RPLP1, RPLP2）, are expressed in a tissue-specific manner. （2） Most promoters have GC boxes and possible binding sites for nuclear respiratory factor 2, Yin and Yang 1, and/or activator protein 1. However, they do not have canonical TATA boxes. （3） Analysis of the amino acid composition of the encoded proteins indicated a high lysine and arginine content. （4） The major RP genes exhibit a characteristic synonymous codon composition with high rates of G or C in the third-codon position and a high content of AAG, CAG, ATC, GAG, CAC, and CTG. Conclusion: Eleven of the RP genes are still identified as being unique and did not exhibit at least some of the above characteristics, indicating that they may have unknown functions not present in other RP genes. Furthermore, we found sequences conserved between human and mouse genes around the transcription start sites and in the intronic regions. This study suggests certain overall trends and characteristic features of human RP genes. |
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| 書誌情報 |
BMC genomics 巻 7, 号 37, 発行日 2006-02-28 |
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| 出版者 | ||||||
| 出版者 | BioMed Central | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 1471-2164 | |||||
| 書誌レコードID | ||||||
| 収録物識別子タイプ | NCID | |||||
| 収録物識別子 | AA12034967 | |||||
| 著者版フラグ | ||||||
| 出版タイプ | VoR | |||||
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Cite as
Ishii, Kyota, Washio, Takanori, Uechi, Tamayo, Yoshihama, Maki, Kenmochi, Naoya, Tomita, Masaru, 2006, Characteristics and clustering of human ribosomal protein genes: BioMed Central.
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