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Analysis of ribosomal protein gene structures: Implications for intron evolution
http://hdl.handle.net/10458/1812
http://hdl.handle.net/10458/1812ed1505cf-37a6-45d4-95f9-8adb147200bb
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
PLoS06 Yoshi_MRP.pdf (1.1 MB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||
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| 公開日 | 2009-02-05 | |||||
| タイトル | ||||||
| タイトル | Analysis of ribosomal protein gene structures: Implications for intron evolution | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ | journal article | |||||
| 著者 |
吉浜, 麻生
× 吉浜, 麻生× Nakao, Akihiro× Nguyen, Hung D.× Naoya, Kenmochi |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Many spliceosomal introns exist in the eukaryotic nuclear genome. Despite much research, the evolution of spliceosomal introns remains poorly understood. In this paper, we tried to gain insights into intron evolution from a novel perspective by comparing the gene structures of cytoplasmic ribosomal proteins （CRPs） and mitochondrial ribosomal proteins （MRPs）, which are held to be of archaeal and bacterial origin, respectively. We analyzed 25 homologous pairs of CRP and MRP genes that together had a total of 527 intron positions. We found that all 12 of the intron positions shared by CRP and MRP genes resulted from parallel intron gains and none could be considered to be “conserved," i.e., descendants of the same ancestor. This was supported further by the high frequency of proto-splice sites at these shared positions; proto-splice sites are proposed to be sites for intron insertion. Although we could not definitively disprove that spliceosomal introns were already present in the last universal common ancestor, our results lend more support to the idea that introns were gained late. At least, our results show that MRP genes were intronless at the time of endosymbiosis. The parallel intron gains between CRP and MRP genes accounted for 2.3% of total intron positions, which should provide a reliable estimate for future inferences of intron evolution. | |||||
| 書誌情報 |
PLoS genetics en : PLoS genet 巻 2, 号 3, p. 237-242, 発行日 2006-03 |
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| 出版者 | ||||||
| 出版者 | Public Library of Science | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 1553-7390 | |||||
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| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 1553-7404 | |||||
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| 収録物識別子タイプ | NCID | |||||
| 収録物識別子 | AA12073492 | |||||
| 著者版フラグ | ||||||
| 出版タイプ | VoR | |||||
