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Effect of dietary sesamin on metabolic fate of an exogenous linolelaidic acid in perfused rat liver
http://hdl.handle.net/10458/3534
http://hdl.handle.net/10458/35345581565e-a0b8-40f4-9d74-430ea0b5255f
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
FN_864.pdf (1.6 MB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||
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| 公開日 | 2011-12-02 | |||||
| タイトル | ||||||
| タイトル | Effect of dietary sesamin on metabolic fate of an exogenous linolelaidic acid in perfused rat liver | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| キーワード | Sesamin, Linolelaidic acid, Ketone body production, Triacylglycerol secretion, Perfused rat liver | |||||
| 資源タイプ | ||||||
| 資源タイプ | journal article | |||||
| 著者 |
Fukuda, Nobuhiro
× Fukuda, Nobuhiro× Zhang, Lei× Kodama, Masaki× Sakono, Masanobu× Ide, Takashi× Yamamoto, Kyosuke× Sugano, Michihiro |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | To estimate the relative significance of exogenous and endogenous fatty acid substrates in decreasing hepatic triacylglycerol secretion after sesamin feeding, livers from rats fed diets supplemented with and without sesamin （sesamin : episesamin, 1:1, w/w） were perfused in the presence and absence of an exogenous di-trans isomer of linoleic acid （linolelaidic acid, trans,trans-9,12-octadecadienoic acid）. Both exogenous trans fatty acid and dietary sesamin, as compared with respective controls, resulted in a marked increase in hepatic ketogenesis; however, the beta-hydroxybutyrate to acetoacetate ratio was elevated by exogenous fatty acid and decreased by dietary sesamin. On the other hand, hepatic secretions of triacylglycerol, phospholipid and cholesterol were markedly lowered in rats fed sesamin, especially when exogenous fatty acid substrate was provided. The relative significance of the exogenous fatty acid was observed in the dietary sesamin-induced decrease in hepatic secretion of triacylglycerol. These results suggest that increased fatty acid oxidation by dietary sesamin, as reflected by enhanced ketone body production, leads to decreased partition of fatty acid substrates to the esterification pathways, and this in turn reduces the synthesis and secretion of triacylglycerol. The altered metabolism of exogenous fatty acids in the liver was therefore a major determinant for the synthesis and secretion of triacylglycerol. | |||||
| 言語 | en | |||||
| 書誌情報 |
en : Journal of Nutritional Science and Vitaminology 巻 45, 号 4, p. 437-448, 発行日 1999-08-01 |
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| 出版者 | ||||||
| 出版者 | The Vitamin Society of Japan | |||||
| 言語 | en | |||||
| 出版者 | ||||||
| 出版者 | University of Tokyo Press | |||||
| 言語 | en | |||||
| 出版者 | ||||||
| 出版者 | 日本ビタミン学会 | |||||
| 言語 | ja | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 03014800 | |||||
| 書誌レコードID | ||||||
| 収録物識別子タイプ | NCID | |||||
| 収録物識別子 | AA00703822 | |||||
| PubMed番号 | ||||||
| 関連タイプ | isIdenticalTo | |||||
| 識別子タイプ | PMID | |||||
| 関連識別子 | 10575634 | |||||
| 権利 | ||||||
| 言語 | ja | |||||
| 権利情報 | 日本ビタミン学会 | |||||
| 権利 | ||||||
| 言語 | ja | |||||
| 権利情報 | 本文データは学協会の許諾に基づきJournal@rchiveから複製したものである | |||||
| 他の資源との関係 | ||||||
| 関連名称 | http://dx.doi.org/10.3177/jnsv.45.437 | |||||
| 著者版フラグ | ||||||
| 出版タイプ | VoR | |||||
