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小胞体ストレス可視化モデル動物の開発
http://hdl.handle.net/10458/2279
http://hdl.handle.net/10458/227952fd0f35-9862-4ae0-95ab-5306581d0973
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
H-21_kondo-kanae-vol.34-2007.pdf (974.0 kB)
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| Item type | 報告書 / Research Paper(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2009-09-18 | |||||
| タイトル | ||||||
| タイトル | 小胞体ストレス可視化モデル動物の開発 | |||||
| 言語 | ja | |||||
| 言語 | ||||||
| 言語 | jpn | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_18ws | |||||
| 資源タイプ | research report | |||||
| 研究代表者 |
近藤, 慎一
× 近藤, 慎一 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | The endoplasmic reticulum (ER) is an organelle in which secretory and transmembrane proteins are folded or processed, and is susceptible to various stresses that provoke the accumulation of unfolded proteins in the ER lumen. Recently, ER stress has been reported to be linked to neuronal death in various neurodegenerative diseases. Neurons contain the ER not only in the soma, but also in the dendrites, thus presenting a different case to non-neuronal cells and cell lines. The ER in the dendrites has potential functions in local protein synthesis and sorting of synthesized proteins to postsynaptic membranes. It raises the possibility that ER stress and ER stress response could occur locally in the dendrites. Here we showed that ER stress sensors, IRE1, PERK, and ATF6 exist in the ER of both soma and dendrites in primary neurons, and that under ER stress conditions, GRP78/BiP was induced and eIF2α was phosphorylated. Furthermore, XBP1 mRNA was localized in the proximal dendrites where IRE1 was rapidly phosphorylated in response to ER stress. These results indicate that the ER in dendrites could respond to ER stress and retain the capacity of protein quality control. | |||||
| 言語 | ja | |||||
| 著者版フラグ | ||||||
| 出版タイプ | VoR | |||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
