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A Defect in Collagen Receptor-Ca2+ Signaling System in Platelets from Cattle with Chediak-Higashi Syndrome
http://hdl.handle.net/10458/1147
http://hdl.handle.net/10458/11473ca58585-c7fc-4b08-8707-e9f062978047
| 名前 / ファイル | ライセンス | アクション |
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ito schattauer_15_2002_2_334.pdf (208.1 kB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||
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| 公開日 | 2008-02-01 | |||||
| タイトル | ||||||
| タイトル | A Defect in Collagen Receptor-Ca2+ Signaling System in Platelets from Cattle with Chediak-Higashi Syndrome | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| キーワード | Chediak-Higashi syndrome, bovine platelet, Ca2+ mobilization, collagen receptor, rhodocytin | |||||
| 資源タイプ | ||||||
| 資源タイプ | journal article | |||||
| その他（別言語等）のタイトル | ||||||
| その他のタイトル | Impaired response to collagen in CHS platelets | |||||
| 言語 | en | |||||
| 著者 |
伊藤, 勝昭
× 伊藤, 勝昭× 池田, 正浩× Shiraishi, Mitsuya× Kawashima, Sachiko× Moroi, Masaaki× Shin, Yangchol× Morita, Takashi× Horii, Yoichiro× 伊藤, 勝昭 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Decreased platelet aggregation to collagen is a cause for bleeding diathesis of Chediak-Higashi syndrome (CHS). We investigated whether the collagen receptor - Ca2+ signaling system was impaired in platelets from cattle affected with CHS. Collagen-induced increase in cytosolic Ca2+ ([Ca2+]i) was depressed in CHS platelets, which was accompanied by a decrease in production of inositol 1,4,5-trisphosphate. Under the condition that influences of endogenous arachidonic acid metabolites and ADP were excluded, convulxin or collagen-related peptide, which are specific agonists for the collagen receptor GPVI, increased [Ca2+]i similarly in normal and CHS platelets. In contrast, rhodocytin, which was proposed to activate another collagen receptor GPIa/IIa, increased [Ca2+]i much less in CHS platelets than in normal ones. Cytochalasin D, an actin polymerization inhibitor, depressed the response to collagen or rhodocytin but not that to convulxin. Adhesion of CHS platelets to acid soluble type I collagen, which was mediated by GPIa/IIa, was similar to that of normal platelets. These results suggest that a defect in rhodocytin-sensitive pathway is responsible for depression of response to collagen in CHS platelets. It remains to be determined what receptor is associated with the mechanism. | |||||
| 言語 | en | |||||
| 書誌情報 |
en : Thrombosis and Haemostasis 巻 87, 号 2, p. 334-341, 発行日 2002 |
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| 出版者 | ||||||
| 出版者 | Schattauer | |||||
| 言語 | en | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 03406245 | |||||
| 書誌レコードID | ||||||
| 収録物識別子タイプ | NCID | |||||
| 収録物識別子 | AA00863137 | |||||
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| 出版タイプ | VoR | |||||
