| アイテムタイプ |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2025-06-23 |
| タイトル |
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タイトル |
Fenugreek inhibits cathepsin G activity and suppresses the progression of malignant phenotypes in MCF-7 cells |
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言語 |
en |
| 言語 |
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言語 |
eng |
| キーワード |
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言語 |
en |
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キーワード |
Breast cancer |
| キーワード |
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言語 |
en |
|
キーワード |
Cathepsin G |
| キーワード |
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言語 |
en |
|
キーワード |
Fenugreek extracts |
| キーワード |
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言語 |
en |
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キーワード |
MCF-7 |
| キーワード |
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言語 |
en |
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キーワード |
Platelet-activating factor acetylhydrorase 1B2 |
| キーワード |
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言語 |
en |
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キーワード |
Quercetin |
| キーワード |
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言語 |
en |
|
キーワード |
Trigonelline |
| 資源タイプ |
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資源タイプ |
journal article |
| アクセス権 |
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アクセス権 |
open access |
| 著者 |
Tanigawa, Kazunari
Tanikawa, Takashi
Kitamura, Masashi
林, 康広
WEKO
35370
e-Rad_Researcher
70582857
| ja |
林, 康広
宮崎大学
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| ja-Kana |
ハヤシ, ヤスヒロ
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| en |
Hayashi, Yasuhiro
University of Miyazaki
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Search repository
Kiriya, Mitsuo
Nakamura, Yasuhiro
Kawashima, Akira
Fujiwara, Yoko
Morimoto-Kamata, Riyo
Ohkura, Naoki
Yui, Satoru
Karasawa, Ken
Nakamura, Ryosuke
Suzuki, Koichi
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| 抄録 |
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内容記述タイプ |
Abstract |
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内容記述 |
Spices and herbs, which are derived from natural botanical sources, contain many bioactive compounds and play an important role in human health. The general and specific health benefits of these spices and herbs include anti-inflammatory, antioxidant, and anti-tumorigenic activities. Previously, we showed that cathepsin G, which is a neutrophil-derived serine protease localized in human breast cancer tissues, promotes cancer metastasis via induction of platelet-activating factor acetylhydrolase 1B2 (PAFAH1B2) expression in MCF-7 human breast cancer cells. Therefore, although regulation of cathepsin G activity is thought to be important in human breast cancer progression, no compounds that inhibit the activity have been identified for therapeutic purposes. In this study, we screened 50 spice and herb extracts. Peppermint, clove, Sichuan pepper, and fenugreek exhibited strong inhibitory effects on cathepsin G activity and suppressed cathepsin G-induced MCF-7 cell aggregation.; importantly, fenugreek suppressed the increase in PAFAH1B2 expression. The IC50 of 37.38 μg/mL of fenugreek extract that showed inhibitory effect on cathepsin G-induced malignant progression was 5.87 times lower than the concentration that exerted cytotoxic effect. Interestingly, quercetin and trigonelline contained in fenugreek inhibited cathepsin G activity and suppressed the induction of cell aggregation and PAFAH1B2 expression in human breast cancer cells. These results suggest that quercetin and trigonelline are partly responsible for the inhibitory effect of fenugreek on cathepsin G-induced malignant progression of human breast cancer cells. Our findings provide a new breast cancer treatment strategy targeting cathepsin G, and fenugreek may have synergistic effects when combined with therapeutic drugs. |
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言語 |
en |
| bibliographic_information |
en : Biochemistry and Biophysics Reports
巻 42,
p. 102021,
発行日 2025-06
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| 出版者 |
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出版者 |
Elsevier BV |
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言語 |
en |
| ISSN |
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収録物識別子タイプ |
EISSN |
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収録物識別子 |
24055808 |
| item_10001_relation_14 |
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関連タイプ |
isVersionOf |
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識別子タイプ |
DOI |
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関連識別子 |
https://doi.org/10.1016/j.bbrep.2025.102021 |
| 権利 |
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権利情報 |
© 2025 The Authors. Published by Elsevier B.V. |
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言語 |
en |
| 出版タイプ |
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出版タイプ |
VoR |
fulltext (4.2 MB)
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