Effects of the Number of Neoadjuvant Cycles and Addition of Adjuvant Chemotherapy on the Prognosis of Muscle-Invasive Bladder Cancer Treated With Radical Cystectomy

Hatakeyama, Shingo; Taoka, Rikiya; Miki, Jun; Saito, Ryoichi; Fukuokaya, Wataru; Matsui, Yoshiyuki; Kawahara, Takashi; Matsuda, Ayumu; Kawai, Taketo; Kato, Minoru; Sazuka, Tomokazu; Sano, Takeshi; Urabe, Fumihiko; Kashima, Soki; Naito, Hirohito; Murakami, Yoji; Miyake, Makito; Daizumoto, Kei; Matsushita, Yuto; Hayashi, Takuji; Inokuchi, Junichi; Sugino, Yusuke; Shiga, Ken ichiro; Yamaguchi, Noriya; Taguchi, Motohiro; Yasue, Keiji; Abe, Takashige; Nakanishi, Shotaro; Hashine, Katsuyoshi; 藤井, 将人; フジイ, マサト; Fujii, Masato; Nishihara, Kiyoaki; Matsumoto, Hiroaki; Tatarano, Shuichi; Wada, Koichiro; Sekito, Sho; Maruyama, Ryo; Nishiyama, Naotaka; Nishiyama, Hiroyuki; Kitamura, Hiroshi; Ohyama, Chikara

doi:https://doi.org/10.1002/cam4.70782

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Effects of the Number of Neoadjuvant Cycles and Addition of Adjuvant Chemotherapy on the Prognosis of Muscle-Invasive Bladder Cancer Treated With Radical Cystectomy

http://hdl.handle.net/10458/0002001371

名前 / ファイル	ライセンス	アクション
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学術雑誌論文 / Journal Article(1)

公開日

2025-06-23

タイトル

Effects of the Number of Neoadjuvant Cycles and Addition of Adjuvant Chemotherapy on the Prognosis of Muscle-Invasive Bladder Cancer Treated With Radical Cystectomy

言語

eng

キーワード

言語

キーワード

adjuvant chemotherapy

キーワード

言語

キーワード

bladder cancer

キーワード

言語

キーワード

neoadjuvant chemotherapy

キーワード

言語

キーワード

overall survival

キーワード

言語

キーワード

radical cystectomy

資源タイプ

journal article

アクセス権

open access

著者

Hatakeyama, Shingo
Taoka, Rikiya
Miki, Jun
Saito, Ryoichi
Fukuokaya, Wataru
Matsui, Yoshiyuki
Kawahara, Takashi
Matsuda, Ayumu
Kawai, Taketo
Kato, Minoru

Sazuka, Tomokazu
Sano, Takeshi
Urabe, Fumihiko
Kashima, Soki
Naito, Hirohito
Murakami, Yoji
Miyake, Makito
Daizumoto, Kei
Matsushita, Yuto
Hayashi, Takuji
Inokuchi, Junichi
Sugino, Yusuke
Shiga, Ken ichiro
Yamaguchi, Noriya
Taguchi, Motohiro
Yasue, Keiji
Abe, Takashige
Nakanishi, Shotaro
Hashine, Katsuyoshi

藤井, 将人

WEKO 34804
e-Rad_Researcher 10794373

ja	藤井, 将人宮崎大学
ja-Kana	フジイ, マサト
en	Fujii, Masato University of Miyazaki

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Nishihara, Kiyoaki
Matsumoto, Hiroaki

Tatarano, Shuichi

Wada, Koichiro
Sekito, Sho
Maruyama, Ryo

Nishiyama, Naotaka
Nishiyama, Hiroyuki

Kitamura, Hiroshi
Ohyama, Chikara

抄録

内容記述タイプ

Abstract

内容記述

Objective
To evaluate the effects of the number of neoadjuvant chemotherapy (NAC) cycles and the addition of adjuvant chemotherapy (AC) after NAC on overall survival (OS) of patients with muscle-invasive bladder cancer (MIBC).

Patients and Methods
We retrospectively evaluated 1687 patients with cT2-4NxM0 MIBC who received radical cystectomy (RC) alone or RC plus perioperative chemotherapy at 36 institutions within the Japanese Urological Oncology Group. We evaluated the effect of the number of NAC cycles (2 vs. ≥ 3 cycles) and the addition of AC on OS.

Results
Among the 1687 patients analyzed, 946 received a median of three NAC cycles. The pathologic complete response rate did not significantly differ between those who received 2 (22.9%) and ≥ 3 cycles (27.5%, p = 0.112). Moreover, no significant difference in OS was observed between the groups (p = 0.559). Multivariable Cox regression analysis showed that pathologic high-risk (ypT2–4, pT3–4, or pN+) or cisplatin ineligibility were significantly associated with poor OS but not the number of NAC cycles (p = 0.238). We identified 942 pathologically high-risk patients after RC who were eligible for AC. Notably, no significant OS improvement was observed with the addition of AC as intensive perioperative chemotherapy after NAC. The primary limitation was selection bias from confounding by clinical indication.

Conclusions
Our findings showed that three or more NAC cycles and the addition of AC may have limited effects on OS in MIBC patients who received RC.

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bibliographic_information

en : Cancer Medicine

巻 14, 号 9, p. e70782, 発行日 2025-04-29

出版者

Wiley

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収録物識別子タイプ

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収録物識別子

20457634

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2025-06-23 02:36:38.383590

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Effects of the Number of Neoadjuvant Cycles and Addition of Adjuvant Chemotherapy on the Prognosis of Muscle-Invasive Bladder Cancer Treated With Radical Cystectomy

× Hatakeyama, Shingo

× Taoka, Rikiya

× Miki, Jun

× Saito, Ryoichi

× Fukuokaya, Wataru

× Matsui, Yoshiyuki

× Kawahara, Takashi

× Matsuda, Ayumu

× Kawai, Taketo

× Kato, Minoru

× Sazuka, Tomokazu

× Sano, Takeshi

× Urabe, Fumihiko

× Kashima, Soki

× Naito, Hirohito

× Murakami, Yoji

× Miyake, Makito

× Daizumoto, Kei

× Matsushita, Yuto

× Hayashi, Takuji

× Inokuchi, Junichi

× Sugino, Yusuke

× Shiga, Ken ichiro

× Yamaguchi, Noriya

× Taguchi, Motohiro

× Yasue, Keiji

× Abe, Takashige

× Nakanishi, Shotaro

× Hashine, Katsuyoshi

× 藤井, 将人

× Nishihara, Kiyoaki

× Matsumoto, Hiroaki

× Tatarano, Shuichi

× Wada, Koichiro

× Sekito, Sho

× Maruyama, Ryo

× Nishiyama, Naotaka

× Nishiyama, Hiroyuki

× Kitamura, Hiroshi

× Ohyama, Chikara

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