| Item type |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2025-01-21 |
| タイトル |
|
|
タイトル |
Comprehensive analysis of diel rhythmic expression of the medaka toll-like receptor gene family |
|
言語 |
en |
| 言語 |
|
|
言語 |
eng |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
キーワード |
Clock genes |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
キーワード |
Diel rhythmic expression |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
キーワード |
Medaka |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
キーワード |
Tlr gene family |
| 資源タイプ |
|
|
資源タイプ |
journal article |
| アクセス権 |
|
| 著者 |
Hata, Takahiko
Shimawaki, Hidetoshi
Setoguchi, Suzuka
Morimoto, Natsuki
引間, 順一
酒井, 正博
河野, 智哉
|
| 抄録 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
Several immune-related genes, including Toll-like receptors (TLR), are associated with circadian rhythms in mammals. However, information on the circadian rhythmic expression of TLRs in fish is limited. In this study, we aimed to analyze the regulation of diel oscillations in the expression of TLR genes in Japanese medaka (Oryzias latipes). The expression analysis revealed diel expression patterns of tlr1, tlr5m, tlr21, and clock genes (bmal1 and clock1) under a 12 h light:12 h dark cycle. The clock gene response element (E-box) was identified in the transcriptional regulatory regions of tlr1, tlr5m, and tlr21. Moreover, overexpressed bmal1 and clock1 enhanced expression levels of tlr1, tlr5m, and tlr21 in medaka embryo (OLHdrR-e3) cells. The expression of tlr1, tlr5m, and tlr21 was significantly decreased in OLHdrR-e3 after generating a bmal1 knockdown using a morpholino oligo. These results indicate the regulation of the diel rhythmic expression of several fish TLRs by clock genes. |
|
言語 |
en |
| 内容記述 |
|
|
内容記述タイプ |
Other |
|
内容記述 |
Citation: Takahiko Hata, Hidetoshi Shimawaki, Suzuka Setoguchi, Natsuki Morimoto, Jun-Ichi Hikima, Masahiro Sakai, Tomoya Kono, Comprehensive analysis of diel rhythmic expression of the medaka toll-like receptor gene family, Developmental & Comparative Immunology, 154, 105143-105143, 2024-05, https://doi.org/10.1016/j.dci.2024.105143 |
|
言語 |
en |
| 書誌情報 |
en : Developmental & Comparative Immunology
巻 154,
p. 105143-105143,
発行日 2024-05
|
| 出版者 |
|
|
出版者 |
Elsevier BV |
|
言語 |
en |
| ISSN |
|
|
収録物識別子タイプ |
PISSN |
|
収録物識別子 |
0145-305X |
| DOI |
|
|
関連タイプ |
isVersionOf |
|
|
識別子タイプ |
DOI |
|
|
関連識別子 |
https://doi.org/10.1016/j.dci.2024.105143 |
| 権利 |
|
|
言語 |
en |
|
権利情報 |
© 2024 Elsevier Ltd. All rights reserved. |
| 著者版フラグ |
|
|
出版タイプ |
NA |
