| Item type |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2024-09-05 |
| タイトル |
|
|
タイトル |
Expression patterns of aquaporins 1, 3, 5 in canine mammary gland carcinomas |
|
言語 |
en |
| 言語 |
|
|
言語 |
eng |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
キーワード |
aquaporin-1 |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
キーワード |
aquaporin-3 |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
キーワード |
aquaporin-5 |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
キーワード |
canine mammary tumor |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
キーワード |
immunohistochemistry |
| 資源タイプ |
|
|
資源タイプ |
journal article |
| アクセス権 |
|
| 著者 |
Fujimoto, Naruki
Taniguchi, Yoshiki
園田, 紘子
金子, 泰之
Matsuzaki, Toshiyuki
Itoh, Teruo
平井, 卓哉
Uchida, Kazuyuki
池田, 正浩
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| 抄録 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
Aquaporins (AQPs) are water channel proteins, and the expression of AQPs in carcinoma cells has received much attention over the last 15 years. In the veterinary field, however, little is known about the expression of AQPs. In the present study using immunohistochemistry, we examined the expression of AQP1, AQP3, and AQP5 in canine mammary gland carcinomas. The 27 samples comprised 10 grade I, 12 grade II, and 5 grade III samples (See Materials and Methods section for grade classification method). AQP1 was expressed in only 2 of the grade III carcinomas, and the expression was limited to spindle-shaped cells in the solid structure and on the outside of the solid mass. AQP3-positive cells were observed in 20 of 22 grade I and II samples. On the other hand, among grade III carcinomas, AQP3 was expressed only in spindle-shaped cells in 1 sample. AQP5 was expressed in all grade I and II carcinomas but not in the grade III tumors. In addition, enhanced expression of basolateral AQP3 and apical AQP5 was observed in lobular hyperplastic cells. These results suggest that the expression patterns of AQP3 and AQP5 can be of help for judging the grading of canine mammary tumors and that AQP1 is likely to be involved in metastasis. Moreover, AQP3 and AQP5 might be relevant to lactation in female dogs. |
|
言語 |
en |
| 内容記述 |
|
|
内容記述タイプ |
Other |
|
内容記述 |
Citation:
Fujimoto N, Taniguchi Y, Sonoda H, Kaneko Y, Matsuzaki T, Itoh T, Hirai T, Uchida K, Ikeda M. Expression patterns of aquaporins 1, 3, 5 in canine mammary gland carcinomas. J Vet Med Sci. 2024 Feb 8;86(2):168-179. doi: 10.1292/jvms.23-0278. |
|
言語 |
en |
| 書誌情報 |
en : Journal of Veterinary Medical Science
巻 86,
号 2,
p. 168-179
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| 出版者 |
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出版者 |
Japanese Society of Veterinary Science |
|
言語 |
en |
| ISSN |
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|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
0916-7250 |
| ISSN |
|
|
収録物識別子タイプ |
EISSN |
|
収録物識別子 |
1347-7439 |
| DOI |
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|
関連タイプ |
isVersionOf |
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|
識別子タイプ |
DOI |
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|
関連識別子 |
https://doi.org/10.1292/jvms.23-0278 |
| 権利 |
|
|
言語 |
en |
|
権利情報 |
© 2024 by the Japanese Society of Veterinary Science |
| 著者版フラグ |
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|
出版タイプ |
VoR |
article (6.8 MB)
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