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Pivotal role of High-Mobility Group Box 2 in ovarian folliculogenesis and fertility
http://hdl.handle.net/10458/0002000728
http://hdl.handle.net/10458/0002000728138923be-81e9-4802-9d8e-05dbf5e7d2ef
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
article (12 MB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||||||||||||
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| 公開日 | 2024-09-05 | |||||||||||||||
| タイトル | ||||||||||||||||
| タイトル | Pivotal role of High-Mobility Group Box 2 in ovarian folliculogenesis and fertility | |||||||||||||||
| 言語 | en | |||||||||||||||
| 言語 | ||||||||||||||||
| 言語 | eng | |||||||||||||||
| キーワード | ||||||||||||||||
| 言語 | en | |||||||||||||||
| 主題Scheme | Other | |||||||||||||||
| キーワード | HMGB2 | |||||||||||||||
| キーワード | ||||||||||||||||
| 言語 | en | |||||||||||||||
| 主題Scheme | Other | |||||||||||||||
| キーワード | ovary | |||||||||||||||
| キーワード | ||||||||||||||||
| 言語 | en | |||||||||||||||
| 主題Scheme | Other | |||||||||||||||
| キーワード | folliculogenesis | |||||||||||||||
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| 言語 | en | |||||||||||||||
| 主題Scheme | Other | |||||||||||||||
| キーワード | fertility | |||||||||||||||
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| 言語 | en | |||||||||||||||
| 主題Scheme | Other | |||||||||||||||
| キーワード | HMGB1 | |||||||||||||||
| 資源タイプ | ||||||||||||||||
| 資源タイプ | journal article | |||||||||||||||
| アクセス権 | ||||||||||||||||
| 著者 |
白水, 慎一郎
× 白水, 慎一郎× 杉田, 直大× チヨウジヨウフ, ナランツオツク
WEKO
26967
× 山隈, 優× Takeguchi, Kanako
× 石塚, 匠× 田中, 美緒× Fidya× 甲斐, 健吾× 帖佐, 悦男× 山下, 善弘× 越本, 知大× 菱川, 善隆 |
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| 抄録 | ||||||||||||||||
| 内容記述タイプ | Abstract | |||||||||||||||
| 内容記述 | BACKGROUND High-Mobility Group Box 1 (HMGB1) and HMGB2 are chromatin-associated proteins that belong to the HMG protein family, and are involved in the regulation of DNA transcription during cell differentiation, proliferation and regeneration in various tissues. However, the role of HMGB2 in ovarian folliculogenesis is largely unknown. METHODS We investigated the functional role of HMGB1 and HMGB2 in ovarian folliculogenesis and fertilization using C57BL/6 wild type (WT) and HMGB2-knockout (KO) mice. Ovarian tissues were obtained from WT and HMGB2-KO mice at postnatal days 0, 3, 7, and 2, 6 months of age, then performed immunohistochemistry, qPCR and Western blotting analyses. Oocyte fertilization capability was examined by natural breeding and in vitro fertilization experiments. RESULTS In HMGB2-KO mice, ovary weight was decreased due to reduced numbers of oocytes and follicles. Natural breeding and in vitro fertilization results indicated that HMGB2-KO mice are subfertile, but not sterile. Immunohistochemistry showed that oocytes expressed HMGB2, but not HMGB1, in neonatal and adult WT ovaries. Interestingly, in HMGB2-KO ovaries, a compensatory increase in HMGB1 was found in oocyte nuclei of neonatal and 2-month-old mice; however, this was lost at 6 months of age. CONCLUSIONS The depletion of HMGB2 led to alterations in ovarian morphology and function, suggesting that HMGB2 plays an essential role in ovarian development, folliculogenesis and fertilization. |
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| 言語 | en | |||||||||||||||
| 内容記述 | ||||||||||||||||
| 内容記述タイプ | Other | |||||||||||||||
| 内容記述 | Citation: Shirouzu S, Sugita N, Choijookhuu N, Yamaguma Y, Takeguchi K, Ishizuka T, Tanaka M, Fidya, Kai K, Chosa E, Yamashita Y, Koshimoto C, Hishikawa Y. Pivotal role of High-Mobility Group Box 2 in ovarian folliculogenesis and fertility. J Ovarian Res. 2022 Dec 20;15(1):133. doi: 10.1186/s13048-022-01071-4. Erratum in: J Ovarian Res. 2023 Jan 24;16(1):21. doi: 10.1186/s13048-023-01105-5. |
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| 言語 | en | |||||||||||||||
| 書誌情報 |
en : Journal of Ovarian Research 巻 15, p. Article number: 133, 発行日 2022-12-20 |
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| 出版者 | ||||||||||||||||
| 出版者 | Springer Science and Business Media LLC | |||||||||||||||
| 言語 | en | |||||||||||||||
| ISSN | ||||||||||||||||
| 収録物識別子タイプ | EISSN | |||||||||||||||
| 収録物識別子 | 1757-2215 | |||||||||||||||
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| 関連タイプ | isVersionOf | |||||||||||||||
| 識別子タイプ | DOI | |||||||||||||||
| 関連識別子 | https://doi.org/10.1186/s13048-022-01071-4 | |||||||||||||||
| 著者版フラグ | ||||||||||||||||
| 出版タイプ | VoR | |||||||||||||||
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白水, 慎一郎, 杉田, 直大, チヨウジヨウフ, ナランツオツク, 山隈, 優, Takeguchi, Kanako, 石塚, 匠, 田中, 美緒 , Fidya, 甲斐, 健吾, 帖佐, 悦男, 山下, 善弘, 越本, 知大, 菱川, 善隆, 2022, Pivotal role of High-Mobility Group Box 2 in ovarian folliculogenesis and fertility: Springer Science and Business Media LLC, Article number: 133– p.
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