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The Relationship Between PD-1(rs2227981) and PD-L1(rs2890658) Polymorphisms and Urothelial Cell Carcinoma
http://hdl.handle.net/10458/0002000703
http://hdl.handle.net/10458/0002000703fbc9c8ed-859c-4be9-a372-45429a1e08ad
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article (173 KB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||||||
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| 公開日 | 2024-08-28 | |||||||||
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| タイトル | The Relationship Between PD-1(rs2227981) and PD-L1(rs2890658) Polymorphisms and Urothelial Cell Carcinoma | |||||||||
| 言語 | en | |||||||||
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| 言語 | eng | |||||||||
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| 言語 | en | |||||||||
| 主題Scheme | Other | |||||||||
| キーワード | pd-l1 | |||||||||
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| 言語 | en | |||||||||
| 主題Scheme | Other | |||||||||
| キーワード | pd-1 | |||||||||
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| 言語 | en | |||||||||
| 主題Scheme | Other | |||||||||
| キーワード | japanese population | |||||||||
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| 言語 | en | |||||||||
| 主題Scheme | Other | |||||||||
| キーワード | polymorphism | |||||||||
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| 言語 | en | |||||||||
| 主題Scheme | Other | |||||||||
| キーワード | urothelial cell carcinoma | |||||||||
| 資源タイプ | ||||||||||
| 資源タイプ | journal article | |||||||||
| アクセス権 | ||||||||||
| 著者 |
Hlaing, Sa Tin Myo
× Hlaing, Sa Tin Myo
× Damayanti, Putri
× カイン, ジン アウン× 月野, 浩昌× 日野浦, 拓之× 黒田, 嘉紀 |
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| 内容記述タイプ | Abstract | |||||||||
| 内容記述 | Background Urothelial cell carcinoma, which is believed to develop from the urothelium (transitional epithelium), is the most common aggressive tumor and accounts for the ten most prevalent cancers in the world. The risk factors for urothelial cell carcinoma are aging, smoking, gender, and genetic alternations. Programmed cell death1 (PD-1) has been widely described as a negative regulator of T-cells by sending inhibitory signals to the T-cell. Through PD-1 binding with PD-L1 (ligand for PD-1), an inhibitory signal is propagated to the T cell. The polymorphisms of PD-1 and PD-L1 lead to an efficient T-cell response and affect an anti-tumor reaction. The polymorphisms of PD-1 and PD-L1 could also affect the carcinogenesis of human cancer, including urothelial cell carcinoma. Therefore, in this study, we evaluated the relation between PD-1(rs2227981) and PD-L1(rs2890658) polymorphisms and the carcinogenesis of urothelial cell carcinoma. Materials and methods This study was conducted using 211 healthy controls and 256 cases of urothelial cell carcinoma among the Japanese population. The DNA samples were extracted from the peripheral white blood cells of each subject. The genotype was detected by using the Polymerase Chain Reaction-Restriction Fragment Length Polymorphism (PCR-RFLP) method. Results C/T (Adjusted OR 1.55, 95% CI:1.02-2.35) and C/T+T/T (OR 1.46, 95% CI:1.01-2.12) genotypes of PD-1 rs2227981 were significant and risk factors for urothelial cancer. Male with A/A genotype in PD-L1 and CT genotype in PD-1 has a significant higher risk factor compared with other genotypes (Adjusted OR 1.83, 95% CI:1.05-3.21). Conclusions and discussion We found that C/T(PD-1) and “A/A (PD-L1) and C/T(PD-1)” were predominant in urothelial cell carcinoma cases. This indicates that C/T(PD-1) and “A/A (PD-L1) and C/T(PD-1)” genotypes could increase susceptibility to urothelial cell carcinoma. However, since our findings indicated that the effects of PD-1 and PD-L1 polymorphisms included discrepancies, additional research will be needed to evaluate the relationship between human cancer and PD-1 and PD-L1 polymorphisms. This is the first study that seeks to find the relation between PD-1(rs2227981) and PD-L1(rs2890658) polymorphisms concerning urothelial cell carcinoma among the Japanese population. |
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| 言語 | en | |||||||||
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| 内容記述タイプ | Other | |||||||||
| 内容記述 | Citation: Hlaing STM, Damayanti P, Zin Aung K, Tsukino H, Hinoura T, Kuroda Y. The Relationship Between PD-1(rs2227981) and PD-L1(rs2890658) Polymorphisms and Urothelial Cell Carcinoma. Cureus. 2023 Nov 1;15(11):e48120. doi: 10.7759/cureus.48120 |
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| 言語 | en | |||||||||
| 書誌情報 |
en : Cureus 巻 15, 号 11, p. e48120, 発行日 2023-11-01 |
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| 出版者 | Springer Science and Business Media LLC | |||||||||
| 言語 | en | |||||||||
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| 収録物識別子タイプ | ISSN | |||||||||
| 収録物識別子 | 2168-8184 | |||||||||
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| 関連タイプ | isVersionOf | |||||||||
| 識別子タイプ | DOI | |||||||||
| 関連識別子 | https://doi.org/10.7759/cureus.48120 | |||||||||
| 権利 | ||||||||||
| 言語 | en | |||||||||
| 権利情報 | © Copyright 2023 Hlaing et al. | |||||||||
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| 出版タイプ | VoR | |||||||||
