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Unusual topological RNA G-quadruplex formed by an RNA duplex: implications for the dimerization of SARS-CoV-2 RNA
http://hdl.handle.net/10458/0002000701
http://hdl.handle.net/10458/0002000701e2fe9272-9f50-4a88-9480-ecb221cd6908
| 名前 / ファイル | ライセンス | アクション |
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||||||||||||||
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| 公開日 | 2024-08-23 | |||||||||||||||||
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| タイトル | Unusual topological RNA G-quadruplex formed by an RNA duplex: implications for the dimerization of SARS-CoV-2 RNA | |||||||||||||||||
| 言語 | en | |||||||||||||||||
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| 言語 | eng | |||||||||||||||||
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| 資源タイプ | journal article | |||||||||||||||||
| アクセス権 | ||||||||||||||||||
| 著者 |
Wang, Shiyu
× Wang, Shiyu
× Song, Yi
× 賀, 智勇× 實吉, 尚郎× Iwakiri, Rie
× Xu, Pengyu
× Zhao, Chuanqi
× Qu, Xiaogang
× 徐, 岩 |
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| 抄録 | ||||||||||||||||||
| 内容記述タイプ | Abstract | |||||||||||||||||
| 内容記述 | The infectious disease coronavirus 2019 (SARS-CoV-2) is caused by a virus that has RNA as its genetic material. To understand the detailed structural features of SARS-COV-2 RNA, we probed the RNA structure by NMR. Two RNA sequences form a duplex and self-associate to form a dimeric G-quadruplex. The FrG nucleoside was employed as a 19F sensor to confirm the RNA structure in cells by 19F NMR. A FRET assay further demonstrated that the dimeric G-quadruplex resulted in RNA dimerization in cells. These results provide the basis for the elucidation of SARS-COV-2 RNA function, which provides new insights into developing novel antiviral drugs against SARS-COV-2. | |||||||||||||||||
| 言語 | en | |||||||||||||||||
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| 内容記述タイプ | Other | |||||||||||||||||
| 内容記述 | Citation: Wang S, Song Y, He Z, Saneyoshi H, Iwakiri R, Xu P, Zhao C, Qu X, Xu Y. Unusual topological RNA G-quadruplex formed by an RNA duplex: implications for the dimerization of SARS-CoV-2 RNA. Chem Commun (Camb). 2023 Oct 24;59(85):12703-12706. doi: 10.1039/d3cc03192f |
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| 言語 | en | |||||||||||||||||
| 書誌情報 |
en : Chemical Communications 巻 59, 号 85, p. 12703-12706, 発行日 2023 |
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| 出版者 | ||||||||||||||||||
| 出版者 | Royal Society of Chemistry (RSC) | |||||||||||||||||
| 言語 | en | |||||||||||||||||
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| 収録物識別子タイプ | ISSN | |||||||||||||||||
| 収録物識別子 | 1359-7345 | |||||||||||||||||
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| 収録物識別子タイプ | EISSN | |||||||||||||||||
| 収録物識別子 | 1364-548X | |||||||||||||||||
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| 関連タイプ | isVersionOf | |||||||||||||||||
| 識別子タイプ | DOI | |||||||||||||||||
| 関連識別子 | https://doi.org/10.1039/d3cc03192f | |||||||||||||||||
| 権利 | ||||||||||||||||||
| 言語 | en | |||||||||||||||||
| 権利情報 | © The Royal Society of Chemistry 2023 | |||||||||||||||||
| 著者版フラグ | ||||||||||||||||||
| 出版タイプ | VoR | |||||||||||||||||
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Wang, Shiyu, Song, Yi, 賀, 智勇, 實吉, 尚郎, Iwakiri, Rie, Xu, Pengyu, Zhao, Chuanqi, Qu, Xiaogang, 徐, 岩, 2023, Unusual topological RNA G-quadruplex formed by an RNA duplex: implications for the dimerization of SARS-CoV-2 RNA: Royal Society of Chemistry (RSC), 12703–12706 p.
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