| Item type |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2024-08-23 |
| タイトル |
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タイトル |
Unusual topological RNA G-quadruplex formed by an RNA duplex: implications for the dimerization of SARS-CoV-2 RNA |
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言語 |
en |
| 言語 |
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言語 |
eng |
| 資源タイプ |
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資源タイプ |
journal article |
| アクセス権 |
|
| 著者 |
Wang, Shiyu
Song, Yi
賀, 智勇
實吉, 尚郎
Iwakiri, Rie
Xu, Pengyu
Zhao, Chuanqi
Qu, Xiaogang
徐, 岩
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| 抄録 |
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内容記述タイプ |
Abstract |
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内容記述 |
The infectious disease coronavirus 2019 (SARS-CoV-2) is caused by a virus that has RNA as its genetic material. To understand the detailed structural features of SARS-COV-2 RNA, we probed the RNA structure by NMR. Two RNA sequences form a duplex and self-associate to form a dimeric G-quadruplex. The FrG nucleoside was employed as a 19F sensor to confirm the RNA structure in cells by 19F NMR. A FRET assay further demonstrated that the dimeric G-quadruplex resulted in RNA dimerization in cells. These results provide the basis for the elucidation of SARS-COV-2 RNA function, which provides new insights into developing novel antiviral drugs against SARS-COV-2. |
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言語 |
en |
| 内容記述 |
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内容記述タイプ |
Other |
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内容記述 |
Citation:
Wang S, Song Y, He Z, Saneyoshi H, Iwakiri R, Xu P, Zhao C, Qu X, Xu Y. Unusual topological RNA G-quadruplex formed by an RNA duplex: implications for the dimerization of SARS-CoV-2 RNA. Chem Commun (Camb). 2023 Oct 24;59(85):12703-12706. doi: 10.1039/d3cc03192f |
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言語 |
en |
| 書誌情報 |
en : Chemical Communications
巻 59,
号 85,
p. 12703-12706,
発行日 2023
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| 出版者 |
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出版者 |
Royal Society of Chemistry (RSC) |
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言語 |
en |
| ISSN |
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収録物識別子タイプ |
ISSN |
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収録物識別子 |
1359-7345 |
| ISSN |
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収録物識別子タイプ |
EISSN |
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収録物識別子 |
1364-548X |
| DOI |
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関連タイプ |
isVersionOf |
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識別子タイプ |
DOI |
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関連識別子 |
https://doi.org/10.1039/d3cc03192f |
| 権利 |
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言語 |
en |
|
権利情報 |
© The Royal Society of Chemistry 2023 |
| 著者版フラグ |
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出版タイプ |
VoR |
Fulltext (1.4 MB)
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